Determination of a novel gamma-secretase inhibitor in human plasma and cerebrospinal fluid using automated 96 well solid phase extraction and liquid chromatography/tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 863, Issue 1, 2008, Pages 36-45

  Matthews, Catherine Z ^a   Woolf, Eric J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Acylglucuronide; CSF; Gamma secretase inhibitor; HPLC MS MS; Plasma; Tween 20

Indexed keywords

DISEASES; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMA (HUMAN);

ACYLGLUCURONIDE; GAMMA-SECRETASE INHIBITOR;

ENZYME INHIBITION;

GAMMA SECRETASE INHIBITOR; GLUCURONIDE; PHOSPHORIC ACID; POLYSORBATE 20;

ALZHEIMER DISEASE; ARTICLE; ATMOSPHERIC PRESSURE; CEREBROSPINAL FLUID; DRUG DETERMINATION; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NEBULIZER; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

AMYLOID PRECURSOR PROTEIN SECRETASES; AUTOANALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOHEXANES; ENZYME INHIBITORS; FREEZING; GLUCURONIDES; HUMANS; INDICATORS AND REAGENTS; PROPIONIC ACIDS; QUALITY CONTROL; SPECIMEN HANDLING; TANDEM MASS SPECTROMETRY;

EID: 39149105602     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.12.025     Document Type: Article

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