Retrovirus-mediated Drosophila melanogaster multisubstrate deoxyribonucleoside kinase gene therapy of gastric cancer cells in vitro and in vivo

Anticancer Research

Volumn 30, Issue 7, 2010, Pages 2641-2649

  Zhu, Zhi ^a   Zhao, Lei ^b   He, Anning ^b   Huang, Baojun ^a   Karlsson, Anna ^c   Xu, Huimian ^a   Zheng, Xinyu ^a,b  

^a First Affiliated Hospital   (China)

^b CHINA MEDICAL UNIVERSITY   (China)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Bystander effect; Drosophila melanogaster multisubstrate deoxyribonucleoside kinase; Gastric cancer; Retroviral vector; Suicide gene

Indexed keywords

ANTINEOPLASTIC AGENT; CYTARABINE; DROSOPHILA MELANOGASTER MULTISUBSTRATE DEOXYRIBONUCLEOSIDE KINASE; FLUORESCEIN ISOTHIOCYANATE; GREEN FLUORESCENT PROTEIN; LIPOCORTIN 5; NUCLEOSIDE DERIVATIVE; RETROVIRUS VECTOR; THYMINE ARABINOSIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BYSTANDER EFFECT; CANCER CELL; CANCER GENE THERAPY; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG SCREENING; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SUBSTRATE; FLUORESCENCE ACTIVATED CELL SORTING; GENE DIRECTED ENZYME PRODRUG THERAPY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS; STOMACH CANCER; STOMACH CARCINOMA; SUICIDE GENE THERAPY; TUMOR GROWTH; VIRAL GENE DELIVERY SYSTEM; VIRUS RECOMBINANT;

ANIMALS; CELL LINE, TUMOR; DROSOPHILA MELANOGASTER; GENE THERAPY; GENES, TRANSGENIC, SUICIDE; GENETIC VECTORS; HUMANS; MICE; MICE, INBRED BALB C; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RETROVIRIDAE; STOMACH NEOPLASMS; TRANSFECTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77955818584     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Dachs GU, Tupper J and Tozer GM: From bench to bedside for gene-directed enzyme prodrug therapy of cancer. Anticancer Drugs 16: 349-359, 2005. (Pubitemid 40434601)
2. Niculescu-Duvaz I and Springer CJ: Introduction to the background, principles, and state of the art in suicide gene therapy. Mol Biotechnol 30: 71-88, 2005. (Pubitemid 41411170)
3. Tanaka T, Duflot-Dancer A, Tiraby M, Piccoli C, Tiraby G, Yamasaki H and Mesnil M: Bystander effect from cytosine deaminase and uracil phosphoribosyl transferase genes in vitro: a partial contribution of gap junctions. Cancer Lett 282: 43-47, 2009.
4. Cai X, Zhou J, Chang Y, Sun X, Li P and Lin J: Targeting gene therapy for hepatocarcinoma cells with the E. coli purine Phosphorylase suicide gene system directed by a chimeric α-fetoprotein promoter. Cancer Lett 264: 71-82, 2008.
5. Warmann SW, Armeanu S, Heigoldt H, Ruck P, Vonthein R, Heitmann H, Seitz G, Lemken ML, Bitzer M, Fuchs J and Lauer UM: Adenosine-mediated cytosine deaminase/5-fluorocytosine suicide gene therapy of human hepatoblastoma in vitro. Pediatr Blood Cancer 53: 145-151, 2009.
6. Zheng FQ, Xu Y, Yang RJ, Wu B, Tan XH, Qin YD and Zhang QW: Combination effect of oncolytic adenovirus therapy and herpes simplex virus thymidine kinase/ganciclovir in hepatic carcinoma animal models. Acta Pharmacol Sin 30: 617-627, 2009.
7. Hiraoka K, Kimura T, Logg CR, Tai CK, Haga K, Lawson GW and Kasahara N: Therapeutic efficacy of replication-competent retrovirus vector-mediated suicide gene therapy in a multifocal colorectal cancer metastasis model. Cancer Res 67: 5345-5353, 2007. (Pubitemid 46997274)
8. Okada T and Ozawa K: Vector-producing tumor-tracking multipotent mesenchymal stromal cells for suicide cancer gene therapy. Front Biosci 13: 1887-1891, 2008.
9. Natsume A and Yoshida J: Gene therapy for high-grade glioma: current approaches and future directions. Cell Adh Migr 2: 186-191, 2008.
10. Uchibori R, Okada T, Ito T, Urabe M, Mizukami H, Kume A and Ozawa K: Retroviral vector-producing mesenchymal stem cells for targeted suicide cancer gene therapy. J Gene Med 11: 373-381, 2009.
11. Lupo-Stanghellini MT, Provasi E, Bondanza A, Ciceri F, Bordignon C and Bonini C: Clinical impact of suicide gene therapy in allogeneic hematopoietic stem cell transplantation. Hum Gene Ther 2010.
12. Lamoureux F, Trichet V, Chipoy C, Blanchard F, Bouin F and Redini F: Recent advances in the management of osteosarcoma and forthcoming therapeutic strategies. Expert Rev Anticancer Ther 7: 169-181, 2007. (Pubitemid 46277282)
13. Witlox MA, Lamfers ML, Wuisman PI, Curiel DT and Siegal GP: Evolving gene therapy approaches for osteosarcoma using viral vectors: review. Bone 40: 797-812, 2007.
14. Al-Hendy A and Salama S: Gene therapy and uterine leiomyoma: a review. Hum Reprod Update 12: 385-400, 2006. (Pubitemid 43923413)
15. Sharma S and Odunsi K: Targeted therapy for epithelial ovarian cancer. Expert Opin Ther Targets 9: 501-513, 2005. (Pubitemid 40883150)
16. Chevex-Barrios P, Chintagumpala M, Mieler W, Paysse E, Boniuk M, Kozinetz C, Hurwitz MY and Hurwitz RL: Response of retinoblastoma with vitreous tumor seeding to adenovirus-mediated delivery of thymidine kinase followed by ganciclovir. J Clin Oncol 23: 7927-7935, 2005. (Pubitemid 46657392)
17. Prinz C, Schwendy S and Voland P: H. pylori and gastric cancer: shifting the global burden. World J Gastroenterol 12: 5458-5464, 2006. (Pubitemid 44501802)
18. Coburn NG: Lymph nodes and gastric cancer. J Surg Oncol 99: 199-206, 2009.
19. Fumoto S, Nishi J, Nakamura J and Nishida K: Gene therapy for gastric cancer. Current Gene Therapy 8: 187-200, 2008.
20. Tang Q, Zhang D, Wan M and Jin L: Experimental study of the RV-HSV-TK/GCV suicide gene therapy system in gastric cancer. Cancer Biother Radiopharmaceut 22: 755-761, 2007.
21. Azatian A, Yu H, Dai W, Schneiders FI, Botelho NK and Lord RV: Effectiveness of HSV-tk suicide gene therapy driven by the Grp78 stress-inducible promoter in esophagogastric junction and gastric adenocarcinomas. J Gastrointest Surg 13: 1044-1051, 2009.
22. Munch-Petersen B, Piskur J and Sondergaard L: Four deoxynucleoside kinase activities from Drosophila melanogaster are contained within a single monomeric enzyme, a new multifunctional deoxynucleoside kinase. J Biol Chem 273: 3926-3931, 1998. (Pubitemid 28103251)
23. Johansson M, van Rompay AR, Degreve B, Balzarini J and Karlsson A: Cloning and characterization of the multisubstrate deoxyribonucleoside kinase of Drosophila melanogaster. J Biol Chem 274: 23814-23819, 1999. (Pubitemid 129528418)
24. Zheng X, Johansson M and Karlsson A: Retroviral transduction of cancer cell lines with the gene encoding Drosophila melanogaster multisubstrate deoxyribonucleoside kinase. J Biol Chem 275: 39125-39129, 2000. (Pubitemid 32058928)
25. Zheng X, Johansson M and Karlsson A: Nucleoside analoguecytotoxicity and bystander, cell killing of cancer cells expressing Drosophila melanogaster deoxyribonucleoside kinase in the nucleus or cytosol. Biochem Biophys Res Commun 289: 229-233, 2001. (Pubitemid 33108819)
26. Zheng X, Johansson M and Karlsson A: Bystander effects of cancer cell lines transduced with the multisubstrate deoxyribonucleoside kinase of Drosophila melanogaster and synergistic enhancement by hydroxyurea. Mol Pharmacol 60: 262-266, 2001. (Pubitemid 32678290)
27. Arner ES, Spasokoukotskaja T and Eriksson S: Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues. Biochem Biophys Res Commun 188: 712-718, 1992.
28. Hatok J, Babusikova E, Matakova T, Mistuna D, Dobrota D and Racay P: in vitro assays for the evaluation of drug resistance in tumor cells. Clin Exp Med 9: 1-7, 2009.
29. Sutter AP and Fechner H: Gene therapy for gastric cancer: Is it promising? World J Gastroenterol 12: 380-387, 2006.
30. Nakaya H, Ishizu A, Ikeda H, Tahara M, Shindo J, Itoh R, Takahashi T, Asaka M, Ishikura H and Yoshiki T: In vitro model of suicide gene therapy for alpha-fetoprotein- producing gastric cancer. Anticancer Res 23: 3795-3800, 2003.
31. Bertoli A, Franco M, Balzarini J, Johansson M and Karlsson A: Altered deoxyribonucleoside pools in T-lymphoblastoid cells expressing the multisubstrate nucleoside kinase of Drosophila melanogaster. FEBS J 272: 3918-3928, 2005. (Pubitemid 41117223)
32. Knecht W, Mikkelsen NE, Clausen AR, Willer M, Eklund H, Gojkovic Z and Piskur J: Drosophila melanogaster deoxyribonucleoside kinase activates gemcitabine. Biochem Biophys Res Commun 382: 430-433, 2009.
33. Knecht W, Rozpedowska E, Le Breton C, Willer M, Gojkovic Z, Sandrini MP, Joergensen T, Hasholt L, Munch-Petersen B and Piskur J: Drosophila deoxyribonucleoside kinase mutants with enhanced ability to phosphorylate purine analogs. Gene Ther 14: 1278-1286, 2007. (Pubitemid 47303956)
34. Tai CK and Kasahara N: Replication-competent retrovirus vectors for cancer gene therapy. Front Biosci 13: 3083-3095, 2008. (Pubitemid 351589220)