Antiproliferative effect of a novel nitro-oxy derivative of celecoxib in human colon cancer cells: Role of COX-2 and nitric oxide

Anticancer Research

Volumn 30, Issue 7, 2010, Pages 2659-2666

  Bocca, Claudia ^a   Bozzo, Francesca ^a   Bassignana, Andrea ^a   Miglietta, Antonella ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

catenin; Celecoxib; Colon cancer; COX 2; Nitro oxy derivative; PI3K Akt

Indexed keywords

ANTINEOPLASTIC AGENT; BENZYL NITRATE; BETA CATENIN; CELECOXIB; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; NITROOXY DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; CANCER CELL; CELL PROLIFERATION; COLON CANCER; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG STRUCTURE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; BENZYL COMPOUNDS; BETA CATENIN; CELL GROWTH PROCESSES; CELL MEMBRANE; CELL NUCLEUS; COLONIC NEOPLASMS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HT29 CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; NITRATES; NITRIC OXIDE; NITRIC OXIDE DONORS; PYRAZOLES; SULFONAMIDES;

EID: 77955801063     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Ding H, Han C, Zhu J, Chen CS and D'Ambrosio SM: Celecoxib derivatives induce apoptosis via the disruption of mitochondrial membrane potential and activation of caspase 9. Int J Cancer 113: 803-810, 2005. (Pubitemid 40101263)
2. Reddy BS and Rao CV: Novel approaches for colon cancer prevention by cyclooxygenase-2 inhibitors. J Environ Pathol Toxicol Oncol 21: 155-164, 2002. (Pubitemid 34655036)
3. Elder DJ and Paraskeva C: COX-2 inhibitors for colorectal cancer. Nat Med 4: 392-393,1998.
4. Müller-Decker K and Fürstenberger G: The cyclooxygenase-2- mediated prostaglandin signaling is causally related to epithelial carcinogenesis. Mol Carcinog 46: 705-710, 2007.
5. Eisinger AL, Prescott SM, Jones DA and Stafforini DM: The role of cyclooxygenase-2 and prostaglandins in colon cancer. Prostaglandins Other Lipid Mediat 82: 147-154, 2007. (Pubitemid 44880176)
6. Motsko SP, Rascati KL, Busti AJ, Wilson JP, Barner JC, Lawson KA and Worchel J: Temporal relationship between use of NSAIDs, including selective COX-2 inhibitors, and cardiovascular risk. Drug Saf 29: 621-632, 2006.
7. Caporali R and Montecucco C: Cardiovascular effects of coxibs. Lupus 14: 785-788, 2005.
8. Brophy JM: Cardiovascular effects of cyclooxygenase-2 inhibitors. Curr Opin Gastroenterol 23: 617-624, 2007.
9. Antman EM, DeMets D and Loscalzo J: Cyclooxygenase inhibition and cardiovascular risk. Circulation 112: 759-770, 2005.
10. Boschi D, Lazzarato L, Rolando B, Filieri A, Cena C, Di Stilo A, Fruttero R and Gasco A: Nitrooxymethyl-substituted analogues of celecoxib: synthesis and pharmacological characterization. Chem Biodivers 6: 369-379, 2009.
11. Rigas B and Williams JL: NO-releasing NSAIDs and colon cancer chemoprevention: a promising novel approach. Int J Oncol 20: 885-890, 2002.
12. Bozzo F, Bassignana A, Lazzarato L, Boschi D, Gasco A, Bocca C and Miglietta A: Novel nitro-oxy derivatives of celecoxib for the regulation of colon cancer cell growth. Chem Biol Interact 182: 183-190, 2009.
13. Khaleghpour K, Li Y, Banville D, Yu Z and Shen SH: Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma. Carcinogenesis 25: 241-248, 2004. (Pubitemid 38239808)
14. Itoh N, Semba S, Ito M, Takeda H, Kawata S and Yamakawa M: Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma. Cancer 94: 3127-3134, 2002. (Pubitemid 34670495)
15. 2 kinase phosphorylation. Circulation 111: 1685-1689, 2005. (Pubitemid 40525170)
16. Arico S, Pattingre S, Bauvy C, Gane P, Barbat A, Codogno P and Ogier-Denis E: Celecoxib induces apoptosis by inhibiting 3-phosphoinositide- dependent protein kinase-1 activity in the human colon cancer HT-29 cell line. J Biol Chem 277: 27613-27621, 2002. (Pubitemid 34966703)
17. Shishodia S, Koul D and Aggarwal BB: Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis. J Immunol 173: 2011-2022, 2004. (Pubitemid 38971638)
18. Kim SJ, Jeong HJ, Choi IY, Lee KM, Park RK, Hong SH and Kim HM: Cyclooxygenase-2 inhibitor SC-236 (4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1- pyrazol-1-I) benzenesulfonamide) suppresses nuclear factor-kappaB activation and phosphorylation of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase, and c-Jun N-terminal kinase in human mast cell line cells. J Pharmacol Exp Ther 314: 27-34, 2005.
19. Cheng J, Imanishi H, Liu W, Nakamura H, Morisaki T, Higashino K and Hada T: Involvement of cell cycle regulatory proteins and MAP kinase signaling pathway in growth inhibition and cell cycle arrest by a selective cyclooxygenase 2 inhibitor, etodolac, in human hepatocellular carcinoma cell lines. Cancer Sci 95: 666-673, 2004. (Pubitemid 39255815)
20. Cusimano A, Foderà D, D'Alessandro N, Lampiasi N, Azzolina A, Montalto G and Cervello M: Potentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatic cancer cells by inhibition of the MEK/ERK pathway. Cancer Biol Ther 6: 1461-1468, 2007. (Pubitemid 351590359)
21. Uddin S, Ahmed M, Hussain A, Assad L, AI-Dayel F, Bavi P, Al-Kuraya KS and Munkarah A: Cyclooxygenase-2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer. Int J Cancer 126: 382-394, 2009.
22. Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park KK and Lee SS: Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat Res 480-481: 243-268, 2001.
23. Marnett LJ and DuBois RN: COX-2: a target for colon cancer prevention. Annu Rev Pharmacol Toxicol 42: 55-80, 2002. (Pubitemid 34160519)
24. Chan TA: Nonsteroidal anti-inflammatory drugs, apoptosis, and colon-cancer chemoprevention. Lancet Oncol 3: 166-174, 2002.