Pyrrolidine dithiocarbamate treatment prevents ethylene glycol-induced urolithiasis through inhibition of NF-kB and p38-MAPK signaling pathways in rat kidney

Archivio Italiano di Urologia e Andrologia

Volumn 82, Issue 2, 2010, Pages 87-94

  Ilbey, Yusuf Özlem ^a,b   Özbek, Emin ^a,b   Şimşek, Abdulmuttalip ^a,b   Cekmen, Mustafa ^c   Somay, Adnan ^a,b   Tasci, Ali Ihsan ^d  

^a Bezm i Alem Valide Sultan Vakif Gureba Research and Education Hospital   (Turkey)

^b Istanbul Vakif Gureba Research and Education Hospital   (Turkey)

^c KOCAELI UNIVERSITY   (Turkey)

^d Bakirkoy Maternity and Children's Research Hospital   (Turkey)

Author keywords

Calcium oxalate crystals; Inducible nitric oxide synthatase (iNOS); Lipid peroxidation; oxidative stress; Nuclear factor kappa B (NF kb); p38 MAPK (mitogene activated protein kinase); Pyrrolidine dithiocarbamate

Indexed keywords

ETHYLENE GLYCOL; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; OXALIC ACID; PYRROLIDINE DITHIOCARBAMATE; SYNAPTOTAGMIN I; ANTIOXIDANT; PYRROLIDINE DERIVATIVE; PYRROLIDINE DITHIOCARBAMIC ACID; THIOCARBAMIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CRYSTALLIZATION; DISEASE MARKER; DISEASE SEVERITY; ENZYME ACTIVITY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INHIBITION KINETICS; KIDNEY; KIDNEY TUBULE; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PROTEIN EXPRESSION; RAT; TRANSMISSION ELECTRON MICROSCOPY; UROLITHIASIS; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; DRUG EFFECTS; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIOXIDANTS; ETHYLENE GLYCOL; MALE; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; THIOCARBAMATES; UROLITHIASIS;

EID: 77955788901     PISSN: 11243562     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Dietrich BL, Blaschke R, Schmadt W. Results of 5035 stone analysis. A contrubition to epidemiology of urinary stone disease. Scand J Urol Nephrol 1990; 24:205-210.
2. Khan SR. Animal models of kidney stone formation: an analysis. World J Urol 1997; 154:236-243. (Pubitemid 127764011)
3. Thamilselvan S, Khan SR. Oxalate and calcium oxalate crystals are injurious to renal epithelial cells: results of in vivo and in vitro studies. J Nephrol 1998; 11:66-69.
4. Selvam R, Kalaiselvi P. Studies on calcium oxalate binding proteins: effect of lipid peroxidation. Nephron 2001; 88:163-167.
5. Thamilselvan S, Hackett RL, Khan SR. Lipid peroxidation in ethylene glycol induced hyperoxaluria and calcium oxalate nephrolithiasis. J Urol 1997; 157:1059-1063.
6. Xie QW, Kashiwabara Y, Nathan C. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J Biol Chem 1994; 269:4705-4708.
7. Angel P, Karin M. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta 1991; 1072:129-157.
8. Baldwin AS Jr. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 1996; 14: 649-683.
9. Blackwell TS, Christman JW. The role of nuclear factor-kappa B in cytokine gene regulation. Am J Respir Cell Mol Biol 1997; 17:3-9.
10. Pahan K, Sheikh FG, Namboodiri AM, et al. N-acetyl cysteine inhibits induction of no production by endotoxin or cytokine stimulated rat peritoneal macrophages, C6 glial cells and astrocytes. Free Radic Biol Med 1998; 24: 39-48.
11. Lee JK, Choi SS, Won JS, et al. The regulation of inducible nitric oxide synthase gene expression induced by lipopolysaccharide and tumor necrosis factor-alpha in C6 cells: involvement of AP-1 and NFkappaB. Life Sci 2003; 73:595-609.
12. Bokemeyer D, Ostendorf T, Kunter U, et al. Differential activation of mitogen-activated protein kinases in experimental mesangioproliferative glomerulonephritis. J Am Soc Nephrol 2000; 11:232-240. (Pubitemid 30064846)
13. Kumar S, Boehm J, Lee JC. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Nat Rev Drug Discov 2003; 2:717-726.
14. Stambe C, Atkins RC, Tesch GH, et al. Blockade of p38alpha MAPK ameliorates acute inflammatory renal injury in rat anti-GBM glomerulonephritis. J Am Soc Nephrol 2003; 14:338-351. (Pubitemid 36150857)
15. Ohashi R, Nakagawa T, Watanabe S, et al. Inhibition of p38 mitogen-activated protein kinase augments progression of remnant kidney model by activating the ERK pathway. Am J Pathol 2004; 164:477-485.
16. Bokemeyer D, Sorokin A, Dunn MJ. Multiple intracellular MAP kinase signaling cascades. Kidney Int 1996; 49:1187-1198. (Pubitemid 26166398)
17. Donnahoo KK, Shames BD, Harken AH, et al. Review article: the role of tumor necrosis factor in renal ischemia-reperfusion injury. J Urol 1999; 162:196-203.
18. Lieberthal W. Biology of ischemic and toxic renal tubular cell injury: role of nitric oxide and the inflammatory response. Curr Opin Nephrol Hypertens 1988; 7:289-295.
19. Chatterjee PK, Patel NS, Kvale EO, et al. Inhibition of inducible nitric oxide synthase reduces renal ischemia/reperfusion injury. Kidney Int 2002; 61:862-871. (Pubitemid 34175453)
20. Liu SF, Ye X, Malik AB. Pyrrolidine dithiocarbamate prevents I-kappaB degradation and reduces microvascular injury induced by lipopolysaccharide in multiple organs. Mol Pharmacol 1999; 55:658-667.
21. Virlos I, Mazzon E, Serraino I, et al. Pyrrolidine dithiocarbamate reduces the severity of cerulein-induced murine acute pancreatitis. Shock 2003; 20:544-550.
22. Si X, McManus BM, Zhang J, et al. Pyrrolidine dithiocarbamate reduces coxsackievirus B3 replication through inhibition of the ubiquitin-proteasome pathway. J Virol 2005; 79:8014-8023.
23. Schreck R, Meier B, Männel DN, et al. Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells. J Exp Med 1992; 175:1181-1194.
24. Gukovsky I, Gukovskaya AS, Blinman TA, et al. Early NF-kappaB activation is associated with hormone-induced pancreatitis. Am J Physiol 1998; 275:1402-1414. (Pubitemid 29029091)
25. Bowie A, O'Neil LA. Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries. Biochem Pharmacol 2000; 59:13-23.
26. Tugcu V, Ozbek E, Tasci AI, et al. Selective nuclear factor kappa-B inhibitors, pyrolidium dithiocarbamate and sulfasalazine, prevent the nephrotoxitity induced by gentamicin. BJU Int 2006; 98:680-686.
27. Tian XF, Yao JH, Li YH, et al. Protective effect of pyrrolidine dithiocarbamate on liver injury induced by intestinal ischemia-reperfusion in rats. Hepatobiliary Pancreat Dis Int 2006; 5:90-95. (Pubitemid 43298710)
28. Houghton DC, Plamp CE, DeFehr JM, et al. Gentamicin and tobramycin nephrotoxicity. A morphologic and functional comparison in the rat. Am J Pathol 1978; 93:137-152. (Pubitemid 9003861)
29. Granger DL, Taintor RR, Boockvar KS, et al. Measurement of nitrate and nitrite in biological samples using nitrate reductase and Griess reaction. Methods Enzymol 1999; 268:142-151.
30. Wasowicz W, Neve J, Peretz A. Optimized steps in fluorometric determination thiobarbituric acid-reactive substances in serum: importance of extraction pH and influence sample preservation and storage. Clin Chem 1993; 39:2522-2528.
31. Beutler E. Glutathione in red blood cell metabolism. A Manual of Biochemical Methods. Grune and Stratton, New York 1975; 112-114.
32. Jungers P, Daudon M. Epidemiology of kidney calculi. Presse Med 1990; 19:1655-1657.
33. Halliwell B, Grootveld M. The measurement of free radical reactions in humans. Some thoughts for future experimentation. FEBS Lett 1987; 213:9-14.
34. Boevé ER, Ketelaars GA, Vermeij M, et al. An ultrastructural study of experimentally induced microliths in rat proximal and distal tubules. J Urol 1993; 149:893-899.
35. Lee YH, Huang WC, Chiang H, et al. Determinant role of testosterone in the pathogenesis of urolithiasis in rats. J Urol 1992; 147:1134-1138.
36. Khan SR. Pathogenesis of oxalate urolithiasis: lessons from experimental studies with rats. Am J Kidney Dis 1991; 17:398-401.
37. Atmani F, Slimani Y, Mimouni M, et al. Effect of aqueous extract from Herniaria hirsuta L. on experimentally nephrolithiasic rats. J Ethnopharmacol 2004; 95:87-93.
38. Touhami M, Laroubi A, Elhabazi K, et al. Lemon juice has protective activity in a rat urolithiasis model. BMC Urol 2007; 7:18-26.
39. Itoh Y, Yasui T, Okada A, et al. Preventive effects of green tea on renal stone formation and the role of oxidative stress in nephrolithiasis. J Urol 2005; 173:271-275. (Pubitemid 39627733)
40. Jang J, Park EY, Seo SI, et al. Effects of intravesical instillation of cyclooxygenase-2 inhibitor on the expression of inducible nitric oxide synthase and nerve growth factor in cyclophosphamide-induced overactive bladder. BJU Int 2006; 98:435-439.
41. Sakurai H, Hisada Y, Ueno M, et al. Activation of transcription factor NF-kappa B in experimental glomerulonephritis in rats. Biochim Biophys Acta 1996; 1316:132-138. (Pubitemid 26193966)
42. Wendt T, Zhang YM, Bierhaus A, et al. Tissue factor expression in an animal model of hydronephrosis. Nephrol Dial Transplant 1995; 10:1820-1828.
43. Khachigian LM, Collins T, Fries JW. N-acetyl cysteine blocks mesangial VCAM-1 and NF-kappa B expression in vivo. Am J Pathol 1997; 151:1225-1229.
44. Ruiz-Ortega M, Bustos C, Hernández-Presa MA, et al. Angiotensin II participates in mononuclear cell recruitment in experimental immune complex nephritis through nuclear factor-kappa B activation and monocyte chemoattractant protein-1 synthesis. J Immunol 1998; 161:430-439.
45. Goligorsky MS, Brodsky SV, Noiri E. Nitric oxide in acute renal failure: NOS versus NOS. Kidney Int 2002; 61:855-861. (Pubitemid 34175452)
46. Fischer PA, Dominguez GN, Cuniberti LA, et al. Hyperhomocysteinemia induces renal hemodynamic dysfunction: is nitric oxide involved? J Am Soc Nephrol 2003; 14:653-660.
47. Donnahoo KK, Shames BD, Harken AH, et al. Review article: the role of tumor necrosis factor in renal ischemia-reperfusion injury. J Urol 1999; 162:196-203.
48. Polat A, Parlakpinar H, Tasdemir S, et al. Protective role of aminoguanidine on gentamicin-induced acute renal failure in rats. Acta Histochem 2006; 108:365-371. (Pubitemid 44584348)
49. Juan SH, Chen CH, Hsu YH, et al. Tetramethylpyrazine protects rat renal tubular cell apoptosis induced by gentamicin. Nephrol Dial Transplant 2007; 22:732-739. (Pubitemid 46351679)