N-acetyl cysteine blocks mesangial VCAM-1 and NF-κB expression in vivo

American Journal of Pathology

Volumn 151, Issue 5, 1997, Pages 1225-1229

  Khachigian, Levon M ^a   Collins, Tucker ^b   Fries, Jochen W U ^b,c  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; FEMALE; GENE EXPRESSION REGULATION; IMMUNE COMPLEX NEPHRITIS; MALE; MESANGIUM; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION;

ACETYLCYSTEINE; ANIMALS; ANTIMETABOLITES; BUTHIONINE SULFOXIMINE; DRUG SYNERGISM; FEMALE; FREE RADICAL SCAVENGERS; GLOMERULAR MESANGIUM; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED STRAINS; NF-KAPPA B; PROMOTER REGIONS (GENETICS); VASCULAR CELL ADHESION MOLECULE-1;

EID: 0030722072     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Wuthrich RP: Vascular cell adhesion molecule-1 (VCAM-1) expression in murine lupus nephritis. Kidney Int 1992, 42:903-914
2. Fries JWU, Williams AJ, Atkins RC, Newman W, Lipscomb MF, Collins T: Expression of VCAM-1 and E-selectin in an in vivo model of endothelial activation. Am J Pathol 1993, 143:725-737
3. Khachigian LM, Collins T, Fries JWU: Nuclear factor-κB mediates induction of vascular cell adhesion molecules-1 in glomerular mesangial cells Biochem Biophys Res Commun 1995, 206:462-467
4. Collins T, Read MA, Neish AS, Whitley MZ, Thanos D, Maniatis T: Transcriptional regulation of endothelial cell adhesion molecules. NF-κB and cytokine-inducible enhancers. FASEB J 1995, 9:899-909
5. Schreck R, Rieber P, Baeuerle PA: Reactive oxygen intermediates as apparently widely used messengers in the activation of NF-κB transcription factor and HIV-1. EMBO J 1991, 10:2247-2258
6. Marui N, Offermann MK, Swerlick R, Kunsch C, Rosen CA, Ahmad M, Alexander RW, Medford RM: Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells J Clin Invest 1993, 92:1866-1874
7. Aruoma OI, Halliwell B, Hoey BM, Butler J: The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydoxyl radicals, superoxide, and hypochloric acid. Free Radical Biol Med 1989, 6:593-597
8. Schreck R, Baeuerle P: A role for oxygen radicals as second messengers. Trends Cell Biol 1991, 1:3942-3948
9. Shan Z, Tan D, Satriano J, Silbiger S, Schlondorff D: Intracellular glutathione influences collagen generation by mesangial cells. Kidney Int 1994, 46:388-395
10. Drew R, Miners JO: The effect of buthionine sulfoximine (BSO) on glutathione depletion and xenobiotic biotransformation. Biochem Pharmacol 1984, 33:2989-2994
11. Molitor JA, Walker WH, Doerre S, Ballard DW, Greene WC: NF-κB: a family of inducible and differentially expressed enhancer-binding proteins in human T cells. Proc Natl Acad Sci USA 1990, 87:10028-10032
12. Müller JM, Löms Ziegler-Heitbrock HW, Baeuerle PA: Nuclear factor-κB, a mediator of lipopolysaccharide effects. Immunobiology 1993, 187:233-256
13. Shah SV: Role of reactive oxygen metabolites in experimental glomerular disease. Kidney Int 1989, 35:1093-1106
14. Morgan LR, Holdiness MR, Gillen LE: N-acetyl-cysteine: its bioavailability and interaction with ifosamide metabolites. Semin Oncol 1983,
15. Schulze-Osthoff K, Beyaert R, Vandevoorde V, Haegeman G, Fiers W: Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effect of TNF. EMBO J 1993, 12:3095-3104
16. Anderson MT, Staal FJT, Gitler C, Herzenberg LA: Separation of oxidant-initiated and redox-regulated steps in the NF-κB signal transduction pathway. Proc Natl Acad Sci USA 1994, 91:11527-11531
17. Tetsuka T, Srivastava SK, Morrison AR: Tyrosine kinase inhibitors genistein and herbimycin A, do not block IL-1β-induced activation of NF-κB in rat mesangial cells. Biochem Biophys Res Commun 1996, 218:808-812
18. Schieven GL, Kirihara JM, Myers DE, Ledbetter JA, Uckun FM: Reactive oxygen intermediates activate NF-κB in a tyrosine kinase dependent mechanism and in combination with vanadate activate the p561ck and p59fyn tyrosine kinases in human lymphocytes. Blood 1993, 82:1212-1220
19. Multicenter Study Group: Long term oral acetylcysteine in chronic bronchitis, a double-blind controlled study. Eur J Respir Dis 1980, 61:93-108
20. Prescott LF, Ballantyne A, Park J, Adriaensens P, Proudfoot AT: Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine. Lancet 1977, 2:432-434
21. Pendyala L, Creaven PJ: Pharmacokinetic and pharmacodynamic studies of N-acetylcysteine, a potential chemopreventative agent during a phase I trial. Cancer Epidemiol Biomarkers Preven 1995, 4:245-251
22. Schreck R, Meier B, Mannel DN, Dröge W, Baeuerle PA: Dithiocarbamates as potent inhibitors of NF-κB activation in intact cells. J Exp Med 1992, 175:1181-1194