Weight gain limitation and liver protection by long-term feeding of astaxanthin in murines

Journal of Applied Biological Chemistry

Volumn 52, Issue 2, 2009, Pages 180-185

  Kim, Sung Han ^a   Jean, Dong Il ^a   Lim, Yong Pyo ^a   Lee, Chanyong ^b   An, Gilhwan ^a  

^a Chungnam National University   (South Korea)

^b Daejeon University   (South Korea)

Author keywords

Astaxanthin; Cholesterol; Liver; Phaffia rhodozyma; Weight gain

Indexed keywords

MUS; PHAFFIA RHODOZYMA; RATTUS;

EID: 77955784905     PISSN: 19760442     EISSN: None     Source Type: Journal    
DOI: 10.3839/jksabc.2009.033     Document Type: Article

References (20)

1. Aebi H (1984) Catalase in vitro. Method Enzymol 105, 121-126, Academic Press, Inc. San Diego, CA, USA.
2. An GH, Song JY, Chang KS, Lee BD, Chae HS, and Jang BG (2004) Pigmentation and delayed oxidation of broiler chickens by the red carotinoid, astaxanthin, from chemical synthesis and the yeast, Xanthophyllomyces dendrorhous. Asian-Aust J Anim Sci 17, 1309-1314.
3. An GH, Song JY, Kwak WK, Lee BD, Song KB, and Choi JE (2006) Improved astaxanthin availability due to drying and rupturing of the red yeast, Xanthophyllomyces dendrorhous. Food Sci Biotechnol 15, 506-510.
4. Bhosale P and Bernstein PS (2005) Microbial xanthophylls. Appl Microbiol Biotechnol 68, 445-455.
5. Higuera-Ciapara I, Félix-Valenzuela L, and Goycoolea FM (2006) Astaxanthin: a review of its chemistry and applications. Crit Rev Food Sci Nutr 46, 185-196.
6. Hussein G, Sankawa U, Goto H, Matsumoto K, and Watanabe H (2006) Astaxanthin, a carotenoid with potential in human health and nutrition. J Nat Prod 69, 443-449.
7. Ikeuchi M, Koyama T, Takahashi J, and Yazawa K (2006) Effects of astaxanthin supplementation on exerciseinduced fatigue in mice. Biol Pharm Bull 29, 2106-2110.
8. Ikeuchi M, Koyama T, Takahashi J, and Yazawa K (2007) Effects of astaxanthin in obese mice fed a high-fat diet. Biol Pharm Bull 71, 893-899.
9. Jewell C and O'Brien NM (1999) Effect of dietary supplementation with carotenoids on xenobiotic metabolizing enzymes in the liver, lung, kidney and small intestine of the rat. Br J Nutr 81, 235-242.
10. Johnson EA and An GH (1991) Astaxanthin from microbial sources. Crit Rev Biotechnol 11, 297-326.
11. Kang JO, Kim SJ, and Kim H (2001) Effect of astaxanthin on the hepatotoxicity, lipid peroxidation and antioxidative enzymes in the liver of CCl4-treated rats. Methods Find Exp Clin Pharmacol 23, 79-84.
12. Kim J, Park JH, Jin H, Cho HS, Hwang SK, Nah WS, Kang HG, An G, and Cho M (2006) Genotoxicity and anti-oxidative effectiveness study of functional food additive containing astaxanthin. J Toxicol Pub Health 22, 381-390.
13. Kim KH, An GH, Cho MH, Lee SH, Choi CM, Cho HD, Lee CH, and Moh IP (1996) Pigmentation of egg yorks with astaxanthin from the yeast Phaffia rhodozyma. Kor J Vet Res 36, 463-470.
14. Naito Y, Uchiyama K, Aoi W, Hasegawa G, Nakamura N, Yoshida N, Maoka T, Takahashi J, and Yoshikawa T (2004) Prevention of diabetic nephropathy by treatment with astaxanthin in diabetic db/db mice. Biofactors 20, 49-59.
15. Ohkawa H, Ohishi N, and Yaki K (1979) Assay for lipid peroxide for animal tissue by thiobarbituric acid reaction. Anal Biochem 95, 351-358.
16. Page GI and Davies SJ (2002) Astaxanthin and canthaxanthin do not induce liver or kidney xenobiotic-metabolizing enzymes in rainbow trout (Oncorhynchus mykiss Walbaum). Comp Biochem Physiol Part C: Toxicol Pharmacol 133, 443-451.
17. Petri D and Lundebye AK (2007) Tissue distribution of astaxanthin in rats following exposure to graded levels in the feed. Comp Biochem Physiol C Toxicol Pharmacol 145, 202-209.
18. Sareen SG, Jack LM, and James LG (2005) Lipids. In Advenced Nutrition and Human Metabolism, pp. 128-171, Thomson/Wadsworth, Belmont, CA, USA.
19. Takahashi K, Watanabe M, Takimoto T, and Akiba Y (2004) Uptake and distribution of astaxanthin in several tissues and plasma lipoproteins in male broiler chickens fed a yeast (Phaffia rhodozyma) with a high concentration of astaxanthin. Br Poult Sci 45, 133-138.
20. Wolz E, Liechti H, Notter B, Oesterhelt G, and Kistler A (1999) Characterization of metabolites of astaxanthin in primary cultures of rat hepatocytes. Drug Metab Dispos 27, 456-462.