Antinociceptive effect of butyl (2-phenylethynyl) selenide on formalin test in mice: Evidences for the involvement of serotonergic and adenosinergic systems

European Journal of Pharmacology

Volumn 644, Issue 1-3, 2010, Pages 49-54

  Luchese, Cristiane ^a   Prigol, Marina ^a   Acker, Carmine Inês ^a   Nogueira, Cristina Wayne ^a  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

Adenosinergic; Antinociception; Butyl (2 phenylethynyl) selenide; Formalin; Selenium; Serotonergic

Indexed keywords

ANTINOCICEPTIVE AGENT; ATROPINE; BUTYL (2 PHENYLETHYNYL)SELENIDE; CAFFEINE; FORMALDEHYDE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; NALOXONE; ONDANSETRON; RITANSERIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG ANTAGONISM; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; MALE; MOUSE; NOCICEPTION; NONHUMAN; PAIN; PAW EDEMA; PRIORITY JOURNAL; REGULATORY MECHANISM; SEROTONINERGIC SYSTEM; SINGLE DRUG DOSE;

ADMINISTRATION, ORAL; ANALGESICS; ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; FORMALDEHYDE; INHIBITORY CONCENTRATION 50; MALE; MICE; ORGANOSELENIUM COMPOUNDS; PAIN; RECEPTORS, PURINERGIC P1; RECEPTORS, SEROTONIN, 5-HT3;

EID: 77955774624     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.06.047     Document Type: Article

References (35)

1. Abbott F.V., Franklin K.B.J., Westbrook R.F. The formalin test: scoring properties of the first and second phases of the pain response in rats. Pain 1995, 60:91-102.
2. Abo-Salem O.M., Hayallah A.M., Bilkei-Gorzo A., Filipek B., Zimmer A., Muller C.E. Antinociceptive effects of novel A2B adenosine receptor antagonists. J. Pharmacol. Exp. Ther. 2004, 308:358-366.
3. Acker C.I., Brandão R., Rosário A.R., Nogueira C.W. Antioxidant effect of alkynylselenoalcohol compounds on liver and brain of rats in vitro. Environ. Toxicol. Pharmacol. 2009, 28:280-287.
4. De Witte J.L., Schoenmaekers B., Sessler D.I., Deloof T. The analgesic efficacy of tramadol is impaired by concurrent administration of ondansetron. Anesth. Analg. 2001, 92:1319-1321.
5. Erdemoglu N., Turan N.N., Akkol E.K., Senera B., Abacioglu N. Estimation of anti-inflammatory, antinociceptive and antioxidant activities on Arctium minus (Hill) Bernh. ssp. minus. J. Ethonopharmacol. 2009, 121:318-323.
6. Furst S. Transmitters involved in antinociception in the spinal cord. Brain Res. Bull. 1999, 48:129-141.
7. Hacimuftuoglu A., Handy C.R., Goettl V.M., Lin C.G., Dane S., Stephens R.L. Antioxidants attenuate multiple phases of formalin-induced nociceptive response in mice. Behav. Brain Res. 2006, 173:211-216.
8. Hong Y., Abbott F.V. Peripheral opioid modulation of pain and inflammation in the formalin test. Eur. J. Pharmacol. 1995, 277:21-28.
9. Hunskaar S., Hole K. The formalin test in mice - dissociation between inflammatory and noninflammatory pain. Pain 1987, 30:103-114.
10. Hunt T.E., Wu W.H., Zbuzek V.K. Ondansetron blocks nifedipine-analgesia induced in rats. Anesth. Analg. 1996, 82:498-500.
11. Jesse C.R., Savegnago S., Nogueira C.W. Role of nitric oxide/cyclic GMP/K+channel pathways in the antinociceptive effect caused by 2, 3-bis(mesitylseleno)propenol. Life Sci. 2007, 81:1694-1702.
12. -/- knock-out male mice. Pain 2007, 130:235-248.
13. Khalil Z., Khodr B. A role for free radicals and nitric oxide in delayed recovery in aged rats with chronic constriction nerve injury. Free Radic. Biol. Med. 2001, 31:430-439.
14. Lopes L.S., Pereira S.S., Silva L.L., Figueiredo K.A., Moura B.A., Almeida F.R.C., Sousa F.C.F. Antinociceptive effect of topiramate in models of acute pain and diabetic neuropathy in rodents. Life Sci. 2009, 84:105-110.
15. Luchese C., Stangherlin E.C., Gay B.M., Nogueira C.W. Antioxidant effect of diphenyl diselenide on oxidative damage induced by smoke in rats: involvement of glutathione. Ecotoxicol. Environ. Saf. 2009, 72:248-254.
16. May S.W. Selenium-based drug design: rationale and therapeutic potential. Exp. Opin. Invest. Drugs 1999, 8:1017-1030.
17. Millan M.J. Descending control of pain. Pain 2002, 66:355-474.
18. Nakamura I., Ohta Y., Kemmotsu O. Characterization of adenosine receptors mediating spinal sensory transmission related to nociceptive information in the rat. Anesthesiology 1997, 87:577-584.
19. Nogueira C.W., Zeni G., Rocha J.B.T. Organosellenium and organotellurium compounds: pharmacology and toxicology. Chem. Rev. 2004, 104:6255-6286.
20. Okoronkwo A.E., Rosário A.R., Alves D., Savegnago L., Nogueira C.W., Zeni G. Synthesis of ω-hydroxy-α-alkyl/aryl-γ-organo-selenium and α-organo-tellurium: a new class of organochalcogen compounds with antinociceptive activity. Tetrahedron Lett. 2008, 49:3252-3256.
21. Pinardi G., Sierralta F., Miranda H.F. Atropine reverses the antinociception of nonsteroidal anti-inflammatory drugs in the tail-flick test of mice. Pharmacol. Biochem. Behav. 2003, 74:603-608.
22. Porciúncula L.O., Rocha J.B.T., Boeck C.R., Vendite D., Souza D.O. Ebselen prevents excitotoxicity provoked by glutamate in rat cerebellar granule neurons. Neurosci. Lett. 2001, 299:217-220.
23. Prigol M., Luchese C., Nogueira C.W. Antioxidant effect of diphenyl diselenide on oxidative stress caused by acute physical exercise in skeletal muscle and lungs of mice. Cell Biochem. Funct. 2009, 27:216-222.
24. Rossato J.I., Ketzer L.A., Centurião F.B., Silva S.J.N., Lüdtke D.S., Zeni G., Braga A.L., Rubin M.A., Rocha J.B.T. Antioxidant properties of new chalcogenides against lipid peroxidation in rat brain. Neurochem. Res. 2002, 3:297-303.
25. Santos A.R.S., Calixto J.B. Further evidence for the involvement of tachykinin receptor subtypes in formalin and capsaicin models of pain in mice. Neuropeptides 1997, 37:381-389.
26. Santos A.R.S., Gadotti V.M., Oliveira G.L., Tibola D., Paszcuk A.F., Neto A., Spindola H.M., Souza M.M., Rodrigues A.L.S., Calixto J.B. Mechanisms involved in the antinociception caused by agmatine in mice. Neuropharmacology 2005, 48:1021-1034.
27. Savegnago L., Jesse C.R., Moro A.V., Borges V.C., Santos F.W., Rocha J.B.T., Nogueira C.W. Bis selenide alkene derivatives: a class of potential antioxidant and antinociceptive agents. Pharmacol. Biochem. Behav. 2006, 83:221-229.
28. Savegnago L., Pinto L.G., Jesse C.R., Alves D., Rocha J.B.T., Nogueira C.W., Zeni G. Antinociceptive properties of diphenyl diselenide: evidences for the mechanism of action. Eur. J. Pharmacol. 2007, 555:129-138.
29. Savegnago L., Jesse C.R., Santos A.R.S., Rocha J.B.T., Nogueira C.W. Mechanisms involved in the antinociceptive effect caused by diphenyl diselenide in the formalin test. J. Pharm. Pharmacol. 2008, 60:1679-1686.
30. Sawynok J. Adenosine receptor activation and nociception. Eur. J. Pharmacol. 1998, 317:1-11.
31. Schewe T. Molecular actions of ebselen-an anti-inflammatory antioxidant. Gen. Pharmacol. 1995, 26:1153-1169.
32. 2 receptors in the antinociceptive effect of Uncaria tomentosa. Pharmacol. Biochem. Behav. 2005, 81:466-477.
33. Wang Z.Q., Porreca F., Cuzzocrea S., Galen K., Lightfoot R., Masini E., Muscoli C., Mollace V., Ndengele M., Ischiropoulos H., Salvemini D. A newly identified role for superoxide in inflammatory pain. J. Pharmacol. Exp. Ther. 2004, 309:869-878.
34. Wess J., Eglen R.M., Gautam D. Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development. Nat. Rev. Drug Discovery 2007, 6:721-733.
35. Zasso F.B., Gonçales C.E.P., Jung E.A.C., Araldi D., Zeni G., Rocha J.B.T., Nogueira C.W. On the mechanisms involved in antinociception induced by diphenyl diselenide. Environ. Toxicol. Pharmacol. 2005, 19:283-289.