Complex actions of neurotensin in ascending and sigmoid colonic muscle: Involvement of enteric mediators

European Journal of Pharmacology

Volumn 644, Issue 1-3, 2010, Pages 195-202

  Azriel, Yael ^a   Liu, Lu ^a   Bucher, Elizabeth ^a,b  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Apamin; Human colon; Indomethacin; Neuronal; Neurotensin; Nifedipine

Indexed keywords

3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; 3 AMINOPROPYLBUTYLPHOSPHINIC ACID; ATROPINE; DARIFENACIN; HEXAMETHONIUM; HISTAMINE; INDOMETACIN; MEN 10627; MEPYRAMINE; MESSENGER RNA; METHOCTRAMINE; N(G) NITROARGININE METHYL ESTER; NEUROKININ 2 RECEPTOR; NEUROTENSIN; NEUROTENSIN 1 RECEPTOR; NEUROTENSIN 3 RECEPTOR; NEUROTENSIN RECEPTOR; NITRIC OXIDE; PROSTAGLANDIN; TACHYKININ; TETRODOTOXIN; UNCLASSIFIED DRUG;

ADULT; AGE DISTRIBUTION; AGED; ANATOMICAL VARIATION; ARTICLE; ASCENDING COLON; COLON TENIA; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; INTESTINE CONTRACTION; MALE; MEDIATOR RELEASE; NEUROTRANSMISSION; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; SEX DIFFERENCE; SIGMOID;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ADULT; AGED; COLON, ASCENDING; COLON, SIGMOID; FEMALE; HUMANS; MALE; MIDDLE AGED; MUSCLE CONTRACTION; NEUROTENSIN; RECEPTORS, NEUROTENSIN; RNA, MESSENGER;

EID: 77955768644     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.06.049     Document Type: Article

References (41)

1. Azriel, Y., 2005. Neurotensin and its receptors in human isolated intestine in health and disease: focus on motility aspects. PhD thesis. University of New South Wales, Australia.
2. Azriel Y., Burcher E. Characterization and autoradiographic localization of neurotensin binding sites in human sigmoid colon. J. Pharmacol. Exp. Ther. 2001, 297:1074-1081.
3. Barrocas A.M., Cochrane D.E., Carraway R.E., Feldberg R.S. Neurotensin stimulation of mast cell secretion is receptor-mediated, pertussis-toxin sensitive and requires activation of phospholipase C. Immunopharmacology 1999, 41:131-137.
4. Bennett A., Stamford I.F., Sanger G.J., Bloom S.R. The effects of various peptides on human isolated gut muscle. J. Pharm. Pharmacol. 1992, 44:960-967.
5. Blackburn A.M., Fletcher D.R., Adrian T.E., Bloom S.R. Neurotensin infusion in man: pharmacokinetics and effect on gastrointestinal and pituitary hormones. J. Clin. Endocrinol. Metab. 1980, 51:1257-1261.
6. Botella A., Delvaux M., Fioramonti J., Frexinos J., Bueno L. Receptor subtypes involved in dual effects induced by prostaglandin E2 in circular smooth muscle from dog colon. J. Pharmacol. Exp. Ther. 1995, 273:1008-1014.
7. 2 receptor and functional mechanisms in human colon: changes with indomethacin and in diverticular disease and ulcerative colitis. J. Pharmacol. Exp. Ther. 2008, 324:170-178.
8. Carraway R.E., Mitra S.P. Binding and biologic activity of neurotensin in guinea pig ileum. Peptides 1994, 15:1451-1459.
9. Castagliuolo I., Wang C.C., Valenick L., Pasha A., Nikulasson S., Carraway R.E., Pothoulakis C. Neurotensin is a proinflammatory neuropeptide in colonic inflammation. J. Clin. Invest. 1999, 103:843-849.
10. Croci T., Aureggi G., Guagnini F., Manara L., Gully D., Fur G.L., Maffrand J.P., Mukenge S., Ferla G., Ferrara P., Chalon P., Vita N. In vitro functional evidence of different neurotensin-receptors modulating the motor response of human colonic muscle strips. Br. J. Pharmacol. 1999, 127:1922-1928.
11. Ehlert F.J., Sawyer G.W., Esqueda E.E. Contractile role of M2 and M3 muscarinic receptors in gastrointestinal smooth muscle. Life Sci. 1999, 64:387-394.
12. Hata F., Takeuchi T., Nishio H., Fujita A. Mediators and intracellular mechanisms of NANC relaxation of smooth muscle in the gastrointestinal tract. J. Smooth Muscle Res. 2000, 36:181-204.
13. Helmstaedter V., Taugner C., Feurle G.E., Forssmann W.G. Localization of neurotensin-immunoreactive cells in the small intestine of man and various mammals. Histochemistry 1977, 53:35-41.
14. Huidobro-Toro J.P., Yoshimura K. Pharmacological characterization of the inhibitory effects of neurotensin on the rabbit ileum myenteric plexus preparation. Br. J. Pharmacol. 1983, 80:645-653.
15. Katsoulis S., Conlon J.M. Neurotensin and prostaglandin interactions in smooth muscle of the guinea pig stomach. Eur. J. Pharmacol. 1988, 158:251-256.
16. Keef K.D., Du C., Ward S.M., McGregor B., Sanders K.M. Enteric inhibitory neural regulation of human colonic circular muscle: role of nitric oxide. Gastroenterology 1993, 105:1009-1016.
17. Kitabgi P. Effects of neurotensin on intestinal smooth muscle: application to the study of structure-activity relationships. Ann. NY Acad. Sci. 1982, 400:37-55.
18. Kitabgi P., Freychet P. Effects of neurotensin on isolated intestinal smooth muscles. Eur. J. Pharmacol. 1978, 50:349-357.
19. Kitabgi P., Freychet P. Neurotensin contracts the guinea-pig longitudinal ileal smooth muscle by inducing acetylcholine release. Eur. J. Pharmacol. 1979, 56:403-406.
20. Kullak A., Donoso M.V., Huidobro-Toro J.P. Extracellular calcium dependence of the neurotensin-induced relaxation of intestinal smooth muscles: studies with calcium channel blockers and BAY K-8644. Eur. J. Pharmacol. 1987, 135:297-305.
21. Kurose M., Saeki K. Histamine release induced by neurotensin from rat peritoneal mast cells. Eur. J. Pharmacol. 1981, 76:129-136.
22. Liu L., Shang F., Markus I., Burcher E. Roles of substance P receptors in human colon circular muscle: alterations in diverticular disease. J. Pharmacol. Exp. Ther. 2002, 302:627-635.
23. Makhlouf G.M., Murthy K.S. Signal transduction in gastrointestinal smooth muscle. Cell. Signal. 1997, 9:269-276.
24. Mako E., Ronai A.Z., Adam G., Juhasz G., Ritter L., Lestar B., Crunelli V. Modulation by GABA(B) and delta opioid receptors of neurally induced responses in isolated guinea-pig taenia coli and human colonic circular muscle. J. Physiol. Paris 2000, 94:135-138.
25. Maselli M.A., Piepoli A.L., Riezzo G., Pezzolla F. Motor responsiveness of proximal and distal human colonic muscle layers to carbachol and neurotensin. Dig. Dis. Sci. 1998, 43:1685-1689.
26. Mashford M.L., Nilsson G., Rokaeus A., Rosell S. The effect of food ingestion on circulating neurotensin-like immunoreactivity (NTLI) in the human. Acta Physiol. Scand. 1978, 104:244-246.
27. Mulè F., Serio R. Mode and mechanism of neurotensin action in rat proximal colon. Eur. J. Pharmacol. 1997, 319:269-272.
28. Mulè F., Serio R., Postorino A. Motility pattern of isolated rat proximal colon and excitatory action of neurotensin. Eur. J. Pharmacol. 1995, 275:131-137.
29. Nguyen-Le X.K., Neugebauer W., Gobeil F., Pheng L.H., Nsa Allogho S., Regoli D. Pharmacological heterogeneity of neurotensin receptors: an in vitro study. Can. J. Physiol. Pharmacol. 1997, 75:547-551.
30. Pelaprat D. Interactions between neurotensin and G proteins. Peptides 2006, 27:2476-2487.
31. Pettibone D.J., Hess J.F., Hey P.J., Jacobson M.A., Leviten M., Lis E.V., Mallorga P.J., Pascarella D.M., Snyder M.A., Williams J.B., Zeng Z. The effects of deleting the mouse neurotensin receptor NTR1 on central and peripheral responses to neurotensin. J. Pharmacol. Exp. Ther. 2002, 300:305-313.
32. Polak J.M., Sullivan S.N., Bloom S.R., Buchan A.M., Facer P., Brown M.R., Pearse A.G. Specific localisation of neurotensin to the N cell in human intestine by radioimmunoassay and immunocytochemistry. Nature 1977, 270:183-184.
33. Riegler M., Castagliuolo I., Wang C., Wlk M., Sogukoglu T., Wenzl E., Matthews J.B., Pothoulakis C. Neurotensin stimulates Cl(-) secretion in human colonic mucosa In vitro: role of adenosine. Gastroenterology 2000, 119:348-357.
34. Rosell S., Rokaeus A. The effect of ingestion of amino acids, glucose and fat on circulating neurotensin-like immunoreactivity (NTLI) in man. Acta Physiol. Scand. 1979, 107:263-267.
35. Rosell S., Thor K., Rokaeus A., Nyquist O., Lewenhaupt A., Kager L., Folkers K. Plasma concentration of neurotensin-like immunoreactivity (NTLI) and lower esophageal sphincter (LES) pressure in man following infusion of (Gln4)-neurotensin. Acta Physiol. Scand. 1980, 109:369-375.
36. Thor K., Rosell S. Neurotensin increases colonic motility. Gastroenterology 1986, 90:27-31.
37. Thor K., Rokaeus A., Kager L., Rosell S. (Gln4)-neurotensin and gastrointestinal motility in man. Acta Physiol. Scand. 1980, 110:327-328.
38. Tomita R., Igarashi S., Fujisaki S., Tanjoh K. The effects of neurotensin in the colon of patients with slow transit constipation. Hepatogastroenterology 2007, 54:1662-1666.
39. Vincent J.P., Mazella J., Kitabgi P. Neurotensin and neurotensin receptors. Trends Pharmacol. Sci. 1999, 20:302-309.
40. Yamaji M., Ohta M., Yamazaki Y., Fujinami K., Fujita A., Takeuchi T., Hata F., Takewaki T. A possible role of neurotensin in NANC relaxation of longitudinal muscle of the jejunum and ileum of Wistar rats. Br. J. Pharmacol. 2002, 137:629-636.
41. Zhao D., Pothoulakis C. Effects of neurotensin on gastrointestinal motility and secretion, and role in intestinal inflammation. Peptides 2006, 27:2434-2444.