A possible role of neurotensin in NANC relaxation of longitudinal muscle of the jejunum and ileum of Wistar rats

British Journal of Pharmacology

Volumn 137, Issue 5, 2002, Pages 629-636

  Yamaji, Michiru ^a   Ohta, Mayuko ^a   Yamazaki, Yasuko ^a   Fujinami, Kaori ^a   Fujita, Akikazu ^a   Takeuchi, Tadayoshi ^a   Hata, Fumiaki ^a   Takewaki, Tadashi ^a  

^a Osaka Prefecture University   (Japan)

Author keywords

Apamin; NANC relaxation; Neurotensin; Nitric oxide; Rat ileum; Rat jejunum

Indexed keywords

2 [[1 (7 CHLORO 4 QUINOLINYL) 5 (2,6 DIMETHOXYPHENYL) 3 PYRAZOLYL]CARBONYLAMINO] 2 ADAMANTANECARBOXYLIC ACID; APAMIN; CALCIUM ACTIVATED POTASSIUM CHANNEL; CHYMOTRYPSIN A; N(G) NITROARGININE; NEUROTENSIN; NITRIC OXIDE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DESENSITIZATION; ELECTROSTIMULATION; EXCITATORY JUNCTION POTENTIAL; ILEUM; INHIBITORY JUNCTION POTENTIAL; INTESTINE MOTILITY; JEJUNUM; MALE; MEMBRANE POTENTIAL; NONADRENERGIC NONCHOLINERGIC NERVE; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTION;

ANIMALS; ELECTRIC STIMULATION; ILEUM; JEJUNUM; MALE; MUSCLE RELAXATION; MUSCLES; NEUROTENSIN; NITRIC OXIDE; NITROARGININE; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; RATS;

EID: 0036848023     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704914     Document Type: Article

References (29)

1. Carraway, R. & Leeman, S.E. (1973). The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami. J. Biol. Chem., 248, 6854-6861.
2. Carraway, R. & Leeman, S.E. (1976). Characterization of radioimmunoassayable neurotensin in the rat. J. Biol. Chem., 251, 7045-7052.
3. Castle, N.A., Haylett, D.C. & Jenkinson, D.H. (1989). Toxins in the characterization of potassium channels. Trends Neurosci., 12, 59-66.
4. De Beurme, F.A. & Lefebvre, R.A. (1987). Influences of α-chymotrypsin and trypsin on the non-adrenergic, non-cholinergic relaxation in the rat gastric fundus. Br. J. Pharmacol., 91, 171-177.
5. Goedert, M., Hunter, J.C. & Ninkovic, M. (1984). Evidence for neurotensin as a non-adrenergic, non-cholinergic neurotransmitter in guinea pig ileum. Nature, 311, 59-62.
6. Gully, D., Canton, M., Boigegrain, R., Jeanjean, F., Molimard, J.C., Poncelet, M., Gueudet, C., Heaulme, M., Leyris, R., Brouard, A., Pelaprat, D., Labbé-Jullié, C., Mazella, J., Soubrié, P., Maffrand, J.P., Rosténe, W., Kitabgi, P. & Le Fur, G. (1993). Biochemical and pharmacological profile of a potent and selective nonpeptide antagonist of the neurotensin receptor. Proc. Natl. Acad. Sci. U.S.A., 90, 65-69.
7. Gully, D., Labeeuw, B., Boigegrain, R., Oury-Donat, F., Bachy, A., Poncelet, M., Steinberg, R., Suaud-Chagny, M.F., Santucci, V., Vita, N., Pecceu, F., Labbé-Jullié, C., Kitabgi, P., Soubrié, P., Lefur, M.G. & Maffrand, J.P. (1997). Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist. J. Pharmacol. Exp. Ther., 280, 802-812.
8. Hammer, R.A., Leeman, S., Carraway, R.E. & Williams, R.H. (1980). Isolation of human intestine neurotensin. J. Biol. Chem., 255, 2476-2480.
9. Hata, F., Ishii, T., Kanada, A., Yamano, N., Kataoka, T., Takeuchi, T. & Yagasaki, O. (1990). Essential role of nitric oxide in descending inhibition in the rat proximal colon. Biochem. Biophys. Res. Commun., 172, 1400-1406.
10. Hata, F., Takeuchi, T., Nishio, H. & Fujita, A. (2000). Mediators and intracellular mechanisms of NANC relaxation of smooth muscle in the gastrointestinal tract. J. Smooth Mus. Res., 36, 181-204.
11. He, X.D. & Goyal, R.K. (1993). Nitric oxide involvement in the peptide VIP-associated inhibitory junction potential in the guinea-pig ileum. J. Physiol. (Lond.), 461, 485-499.
12. Keef, K.D., Du, C., Ward, S.M., McGregor, B. & Sanders, K.M. (1993). Enteric inhibitory neural regulation of human colonic circular muscle: Role of nitric oxide. Gastroenterology, 105, 1009-1016.
13. Kishi, M., Takeuchi, T., Katayama, H., Yamazaki, Y., Nishio, H., Hata, F. & Takewaki, T. (2000). Involvement of cyclic AMP-PKA pathway in VIP-induced, charybdotoxin-sensitive relaxation of longitudinal muscle of the distal colon of Wistar-ST rats. Br. J. Pharmacol., 129, 140-146.
14. + channels. Br. J. Pharmacol., 119, 623-630.
15. Kitabgi, P., Carraway, R.E. & Leeman, S. (1976). Isolation of a tridecapeptide from bovine intestine tissue and its partial characterization as neurotensin. J. Biol. Chem., 251, 7053-7058.
16. Kitabgi, P. & Freychet, P. (1978). Effects of neurotensin on isolated intestinal smooth muscles. Eur. J. Pharmacol., 50, 349-357.
17. Kitabgi, P. & Vincent, J.P. (1981). Neurotensin is a potent inhibitor of guinea-pig colon contractile activity. Eur. J. Pharmacol., 74, 311-318.
18. 3H]SR 48692, the first nonpeptide neurotensin antagonist radioligand: Characterization of binding properties and evidence for distinct agonist and antagonist binding domains on the rat neurotensin receptor. J. Pharmacol. Exp. Ther., 47, 1050-1056.
19. Matsuyama, H., Thapaliya, S. & Takewaki, T. (1999). Cyclic GMP-associated apamin-sensitive nitrergic slow inhibitory junction potential in the hamster ileum. Br. J. Pharmacol., 128, 830-836.
20. McLean, J. & Fox, J.E.T. (1983). Mechanism of action of neurotensin on motility of canine gastric corpus in vitro. Can. J. Physiol. Pharmacol., 61, 29-34.
21. Mulè, F. & Serio, R. (1997). Mode and mechanism of neurotensin action in rat proximal colon. Eur. J. Pharmacol., 319, 269-272.
22. Niioka, S., Takeuchi, T., Kishi, M., Ishii, T., Nishio, H., Takewaki, T. & Hata, F. (1997). Nonadrenergic, noncholinergic relaxation in longitudinal muscle of rat jejunum. Jpn. J. Pharmacol., 73, 155-161.
23. Okishio, Y., Niioka, S., Yamaji, M., Yamazaki, Y., Nishio, H., Takeuchi, T. & Hata, F. (2000). Mediators of nonadrenergic, noncholinergic relaxation in Sprague Dawley rat intestine: Comparison with the mediators of other strains. J. Vet. Med. Sci., 62, 821-828.
24. Suthamnatpong, N., Hosokawa, M., Takeuchi, T., Hata, F. & Takewaki, T. (1994). Nitric oxide-mediated inhibitory response of rat proximal colon: Independence from changes in membrane potential. Br. J. Pharmacol., 112, 676-682.
25. Takeuchi, T., Kishi, M., Hirayama, N., Yamaji, M., Ishii, T., Nishio, H., Hata, F. & Takewaki, T. (1999). Tyrosine kinase involvement in apamin-sensitive inhibitory responses of rat distal colon. J. Physiol., 514, 177-188.
26. Takeuchi, T., Niioka, S., Yamaji, M., Okishio, Y., Ishii, T., Nishio, H., Takatsuji, K. & Hata, F. (1998). Decrease in participation of nitric oxide in nonadrenergic, noncholinergic relaxation of rat intestine with age. Jpn. J. Pharmacol., 78, 293-302.
27. Takeuchi, T., Sugimoto, K., Morimoto, H., Fujita, A. & Hata, F. (2001). Mechanism of a nitric oxide donor, NOR 1-induced relaxation in longitudinal muscle of rat proximal colon. Jpn. J. Pharmacol., 86, 390-398.
28. Takewaki, T. & Ohashi, H. (1977). Non-cholinergic, excitatory transmission to intestinal smooth muscle cells. Nature, 268, 749-750.
29. Watson, M.J., Lang, R.J., Bywater, R.A.R. & Taylor, G.S. (1996). Characterization of the membrane conductance changes underlying the apamin-resistant NANC inhibitory junction potential in the guinea-pig proximal and distal colon. J. Autonom. Nerv. Syst., 60, 31-42.