The effects of hepatitis C virus non-structural protein 3 on cell growth mediated by extracellular signal-related kinase cascades in human hepatocytes in vitro

International Journal of Molecular Medicine

Volumn 26, Issue 2, 2010, Pages 273-279

  Li, Bo ^a   Li, Xiang ^a   Li, Yingxin ^b   Guo, Hui ^a   Sun, Shu Yan ^a   He, Qiong Qiong ^a   Wang, Ying ^a   Luo, Junming ^c,d   Wen, Ji Fang ^a   Zheng, Hui ^a   Feng, De Yun ^a  

^a Central South University   (China)

^b UNC Hamner Institute for Drug Safety Sciences   (United States)

^c AmeriPath   (United States)

^d CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Activator protein 1; Cell growth; Extracellular signal related kinase; Hepatitis c virus non structural protein 3; Nuclear factor B

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CYCLIN D1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NONSTRUCTURAL PROTEIN 3; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR AP 1; 2-(2-AMINO-3-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; CCND1 PROTEIN, HUMAN; ENZYME INHIBITOR; FLAVONOID; NS3 PROTEIN, HEPATITIS C VIRUS; VIRUS PROTEIN;

ARTICLE; BINDING AFFINITY; CELL GROWTH; CELL PROLIFERATION; DNA BINDING; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; LIVER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANALYSIS OF VARIANCE; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION; TUMOR CELL LINE;

ANALYSIS OF VARIANCE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN D1; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; HEPATOCYTES; HUMANS; NF-KAPPA B; PHOSPHORYLATION; TRANSCRIPTION FACTOR AP-1; VIRAL NONSTRUCTURAL PROTEINS;

EID: 77955750672     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm_00000462     Document Type: Article

References (39)

1. Lauer GM and Walker BD: Hepatitis C virus infection. N Engl J Med 345: 41-52, 2001.
2. Hoofnagle JH: Hepatitis C: the clinical spectrum of disease. Hepatology 26: S15-S20, 1997.
3. Grakoui A, Levis R, Raju R, Huang HV and Rice CM: A cisacting mutation in the Sindbis virus junction region which affects subgenomic RNA synthesis. J Virol 63: 5216-5227, 1989.
4. Hong Z, Ferrari E, Wright-Minogue J, Chase R, Risano C, Seelig G, Lee CG and Kwong AD: Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells by using the herpes simplex virus amplicon system. J Virol 70: 4261-4428, 1996.
5. Kim DW, Gwack Y, Han JH and Choe J: C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity. Biochem Biophys Res Commun 215: 160-166, 1995.
6. Santolini E, Pacini L, Fipaldini C, Migliaccio G and Monica N: The NS2 protein of hepatitis C virus is a transmembrane polypeptide. J Virol 69: 7461-7471, 1995.
7. Suzich JA, Tamura JK, Palmer-Hill F, Warrener P, Grakoui A, Rice CM, Feinstone SM and Collett MS: Hepatitis C virus NS3 protein polynucleotide- stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes. J Virol 67: 6152-6158, 1993.
8. Sakamuro D, Furukawa T and Takegami T: Hepatitis C virus nonstructural protein NS3 transforms NIH 3T3 cells. J Virol 69: 3893-3896, 1995.
9. He QQ, Cheng RX, Sun Y, Feng DY, Chen ZC and Zheng H: Hepatocyte transformation and tumor development induced by hepatitis C virus NS3 c-terminal deleted protein. World J Gastroenterol 9: 474-478, 2003. (Pubitemid 36372110)
10. Zhu DH and Wang JB: The culture of HCC host hepatocyte QSG7701 cell line and as compared with hepatocarcinoma cell. Zhongliu Fangzhi Yanjiu 5: 7-9, 1979.
11. He Q, Cheng R, Chen Z, Xiao X, Xiao Z, Li C, Li B, Zhang P, Zheng H and Feng D: Cell transformation and proteome alteration in QSG7701 cells transfected with hepatitis C virus non-structural protein 3. Acta Biochim Biophys Sin 39: 751-762, 2007.
12. Feng DY, Sun Y, Cheng RX, Ouyang XM and Zheng H: Effect of hepatitis C virus nonstructural protein NS3 on proliferation and MAPK phosphorylation of normal hepatocyte line. World J Gastroenterol 11: 2157-2161, 2005.
13. Kolykhalov AA, Agapov EV, Blight KJ, Mihalik K, Feinstone SM and Rice CM: Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA. Science 277: 570-574, 1997.
14. Zemel R, Gerechet S, Greif H, Bachmatove L, Birk Y, Golan-Goldhirsh A, Kunin M, Berdichevsky Y, Benhar I and Tur-Kaspa R: Cell transformation induced by hepatitis C virus NS3 serine protease. J Viral Hepat 8: 96-102, 2001.
15. Zemel R, Kazatsker A, Greif F, Ben-Ari Z, Greif H, Almog O and Tur-Kaspa R: Mutations at vicinity of catalytic sites of hepatitis C virus NS3 serine protease gene isolated from hepatocellular carcinoma tissue. Dig Dis Sc 45: 2199-2202, 2000.
16. Hassan M, Ghozlan H and Abdel-Kader O: Activation of c-Jun NH2-terminal kinase (JNK) signaling pathway is essential for the stimulation of hepatitis C virus (HCV) non-structural protein 3 (NS3)-mediated cell growth. Virology 333: 324-336, 2005.
17. Kwun HJ, Jung EY, Ahn JY, Lee MN and Jang KL: P53-dependent transcriptional repression of p21 (waf 1) by hepatitis C virus NS3. J Gen Virol 82: 2235-2241, 2001.
18. Wada T and Penninger JM: Mitogen-activated protein kinases in apoptosis regulation. Oncogene 23: 2838-2849, 2004. (Pubitemid 38638846)
19. Ito Y, Sasaki Y, Horimoto M, Wada S, Tanaka Y, Kasahara A, Ueki T, Hirano T, Yamamoto H, Fujimoto J, Okamoto E, Hayashi N and Hori M: Activation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma. Hepatology 27: 951-958, 1998.
20. Schmidt CM, McKillop IH, Cahill PA and Sitzmann JV: Increased MAPK expression and activity in primary human hepatocellular carcinoma. Biochem Biophys Res Commun 236: 54-58, 1997.
21. Sewing A, Wiseman B, Lloyd A, et al: High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1. Mol Cell Biol 17: 5588-5597, 1997.
22. Pages G, Lenormand P, Allemain G, et al: Mitogen-activated protein kinase p42MAPK and p44MAPK are required for fibroblast proliferation. Proc Natl Acad Sci USA 90: 8319-8323, 1993.
23. Kerkhoff E and Rapp UR: Cell cycle targets of Ras/Raf signalling. Oncogene 17: 1457-1462, 1998. (Pubitemid 28458413)
24. Zhang W and Liu HT: MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res 12: 9-18, 2002.
25. Hill CS, Wynne J and Treisman R: Serum-regulated transcription by serum response factor (SRF): a novel role for the DNA binding domain. EMBO J 13: 5421-5432, 1994.
26. Shaulian E and Karin M: AP-1 in cell proliferation and survival. Oncogene 20: 2390-2400, 2001.
27. Treinies I, Paterson HF, Hooper S, Wilson R and Marshall CJ: Activated MEK stimulates expression of AP-1 components independently of phosphatidylinositol 3-kinase (PI3-kinase) but requires a PI3-kinase signal to stimulate DNA synthesis. Mol Cell Biol 19: 321-329, 1999.
28. Smith MJ and Prochownik EV: Inhibition of c-jun causes reversible proliferative arrest and withdrawal from the cell cycle. Blood 79: 2107-2115, 1992.
29. Kovary K and Bravo R: The jun and fos protein families are both required for cell cycle progression in fibroblasts. Mol Cell Biol 11: 4466-4472, 1991. (Pubitemid 21895842)
30. Nishikura K and Murray JM: Antisense RNA of proto-oncogene c-fos blocks renewed growth of quiescent 3T3 cells. Mol Cell Biol 7: 639-649, 1987. (Pubitemid 17004527)
31. Guo YL, Kang B, Yang LJ and Williamson JR: Tumor necrosis factor-alpha and ceramide induce cell death through different mechanisms in rat mesangial cells. Am J Physiol 276: 390-397, 1999.
32. Lenczowski JM, Dominguez L, Eder AM, King LB, Zacharchuk CM and Ashwell JD: Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis. Mol Cell Biol 17: 170-181, 1997.
33. Van WC: Nuclear factor-kappaB in development, prevention, and therapy of cancer. Clin Cancer Res 13: 1076-1082, 2007.
34. Guttridge DC, Albanese C, Reuther JY, Pestell RG and Baldwin AS: NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol Cell Biol 19: 5785-5799, 1999.
35. Ghoda L, Lin X and Greene WC: The 90-kDa ribosomal S6 kinase (pp90rsk) phosphorylates the N-terminal regulatory domain of IkappaBalpha and stimulates its degradation in vitro. J Biol Chem 272: 21281-21288, 1997. (Pubitemid 27373994)
36. Barradas M, Monjas A, Diaz-Meco MT, Serrano M and Moscat J: The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression. EMBO J 18: 6362-6369, 1999. (Pubitemid 29533240)
37. Qiu SG, Krishnan S, el-Guendy N and Rangnekar VM: Negative regulation of Par-4 by oncogenic Ras is essential for cellular transformation. Oncogene 18: 7115-7123, 1999.
38. Kato N, Yoshida H, Kioko OS, Kato J, Goto T, Otsuka M, Lan K, Matsushima K, Shiratori Y and Omata M: Activation of intracellular signaling by hepatitis B and C viruses: C-viral core is the most potent signal inducer. Hepatology 32: 405-412, 2000. (Pubitemid 30614674)
39. Yen TS: Nuclear factor kappaB and hepatitis C - Is there a connection? Hepatology 31: 785-787, 2000.