Lgl, the SWH pathway and tumorigenesis: It's a matter of context & competition!

Cell Cycle

Volumn 9, Issue 16, 2010, Pages 3222-3232

  Grzeschik, Nicola A ^a   Parsons, Linda M ^a   Richardson, Helena E ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

aPKC; Cell competition; crb; dlg; Epithelial polarity; JNK pathway; lgl; Neoplastic tumor suppressors; Scrib; SWH pathway

Indexed keywords

CYCLIN A; CYCLIN B; CYCLIN E; PROTEIN KINASE C; RNA; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR E2F1;

APOPTOSIS; BINDING COMPETITION; CANCER INVASION; CARCINOGENESIS; CELL CYCLE PROGRESSION; CELL POLARITY; CELL PROLIFERATION; CELL SURVIVAL; DEPLETION; GENE EXPRESSION; GENE OVEREXPRESSION; GENE TARGETING; HUMAN; MUTANT; OVARY FOLLICLE; PHENOTYPIC VARIATION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; REVIEW; SIGNAL TRANSDUCTION; TISSUE GROWTH; TUMOR SUPPRESSOR GENE;

EID: 77955747440     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.9.16.12633     Document Type: Review

References (66)

1. Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D. Polarity complex proteins. Biochim Biophys Acta 2008; 1778:15-6.
2. Humbert PO, Grzeschik NA, Brumby AM, Galea R, Elsum I, Richardson HE. Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module. Oncogene 2008; 27:6888-907.
3. Gateff E, Schneiderman HA. Developmental capacities of benign and malignant neoplasms of Drosophila. Roux's Arch Dev Biol 1974; 176:23-65.
4. Mechler BM, McGinnis W, Gehring WJ. Molecular cloning of lethal(2)giant larvae, a recessive oncogene of Drosophila melanogaster. EMBO J 1985; 4:1551-7.
5. Woods DF, Bryant PJ. Molecular cloning of the lethal(1)discs large-1 oncogene of Drosophila. Dev Biol 1989; 134:222-35.
6. Bilder D, Li M, Perrimon N. Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science 2000; 289:113-6.
7. Hariharan IK, Bilder D. Regulation of imaginal disc growth by tumor-suppressor genes in Drosophila. Annu Rev Genet 2006; 40:335-61.
8. Eder AM, Sui X, Rosen DG, Nolden LK, Cheng KW, Lahad JP, et al. Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer. Proc Natl Acad Sci USA 2005; 102:12519-24.
9. Grifoni D, Garoia F, Bellosta P, Parisi F, De Biase D, Collina G, et al. aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia. Oncogene 2007; 26:5960-5.
10. Lu H, Bilder D. Endocytic control of epithelial polarity and proliferation in Drosophila. Nat Cell Biol 2005; 7:1232-9.
11. Brumby A, Secombe J, Horsfield J, Coombe M, Amin N, Coates D, et al. A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in Drosophila. Genetics 2004; 168:227-51.
12. Brumby AM, Richardson HE. scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J 2003; 22:5769-79.
13. Grzeschik NA, Amin N, Secombe J, Brumby AM, Richardson HE. Abnormalities in cell proliferation and apico-basal cell polarity are separable in Drosophila lgl mutant clones in the developing eye. Dev Biol 2007; 311:106-23.
14. Grzeschik NA, Parsons LM, Allott ML, Harvey KF, Richardson HE. Lgl, aPKC and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms. Curr Biol 2010; 20:573-81.
15. Robinson BS, Huang J, Hong Y, Moberg KH. Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein expanded. Curr Biol 2010; 20:582-90.
16. Ling C, Zheng Y, Yin F, Yu J, Huang J, Hong Y, et al. The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded. Proc Natl Acad Sci USA 2010.
17. Harvey K, Tapon N. The Salvador-Warts-Hippo pathway-an emerging tumour-suppressor network. Nat Rev Cancer 2007; 7:182-91.
18. Zeng Q, Hong W. The emerging role of the hippo pathway in cell contact inhibition, organ size control and cancer development in mammals. Cancer Cell 2008; 13:188-92.
19. Reddy BV, Irvine KD. The Fat and Warts signaling pathways: new insights into their regulation, mechanism and conservation. Development 2008; 135:2827-38.
20. Badouel C, Garg A, McNeill H. Herding Hippos: regulating growth in flies and man. Curr Opin Cell Biol 2009; 21:837-43.
21. Nicolay BN, Frolov MV. Context-dependent requirement for dE2F during oncogenic proliferation. PLoS Genet 2008; 4:1000205.
22. Goulev Y, Fauny JD, Gonzalez-Marti B, Flagiello D, Silber J, Zider A. SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila. Curr Biol 2008; 18:435-41.
23. Wu S, Liu Y, Zheng Y, Dong J, Pan D. The TEAD/ TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway. Dev Cell 2008; 14:388-98.
24. Zhang L, Ren F, Zhang Q, Chen Y, Wang B, Jiang J. The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. Dev Cell 2008; 14:377-87.
25. Grusche FA, Richardson HE, Harvey KF. Upstream Regulation of the Hippo Size Control Pathway. Curr Biol In Press.
26. Matallanas D, Romano D, Hamilton G, Kolch W, O'Neill E. A Hippo in the ointment: MST signaling beyond the fly. Cell Cycle 2008; 7:879-84.
27. Zhao B, Lei QY, Guan KL. The Hippo-YAP pathway: new connections between regulation of organ size and cancer. Curr Opin Cell Biol 2008; 20:638-46.
28. Bertini E, Oka T, Sudol M, Strano S, Blandino G. YAP: at the crossroad between transformation and tumor suppression. Cell Cycle 2009; 8:49-57.
29. Thacker SA, Bonnette PC, Duronio RJ. The contribution of E2F-regulated transcription to Drosophila PCNA gene function. Curr Biol 2003; 13:53-8.
30. Harvey KF, Pf leger CM, Hariharan IK. The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell 2003; 114:457-67.
31. Tapon N, Harvey KF, Bell DW, Wahrer DC, Schiripo TA, Haber DA, Hariharan IK. salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell 2002; 110:467-78.
32. Hay BA, Huh JR, Guo M. The genetics of cell death: approaches, insights and opportunities in Drosophila. Nat Rev Genet 2004; 5:911-22.
33. Igaki T, Pastor-Pareja JC, Aonuma H, Miura M, Xu T. Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila. Dev Cell 2009; 16:458-65.
34. Leong GR, Goulding KR, Amin N, Richardson HE, Brumby AM. scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs. BMC Biol 2009; 7:62.
35. Zhao M, Szafranski P, Hall CA, Goode S. Basolateral junctions utilize warts signaling to control epithelialmesenchymal transition and proliferation crucial for migration and invasion of Drosophila ovarian epithelial cells. Genetics 2008; 178:1947-71.
36. Grzeschik NA, Knust E. IrreC/rst-mediated cell sorting during Drosophila pupal eye development depends on proper localization of DE-cadherin. Development 2005; 132:2035-45.
37. Badouel C, Gardano L, Amin N, Garg A, Rosenfeld R, Le Bihan T, McNeill H. The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie. Dev Cell 2009; 16:411-20.
38. Milton CC, Zhang X, Albanese NO, Harvey KF. Differential requirement of Salvador-Warts-Hippo pathway members for organ size control in Drosophila melanogaster. Development 2010; 137:735-43.
39. Genevet A, Polesello C, Blight K, Robertson F, Collinson LM, Pichaud F, Tapon N. The Hippo pathway regulates apical-domain size independently of its growth-control function. J Cell Sci 2009; 122:2360-70.
40. Hamaratoglu F, Gajewski K, Sansores-Garcia L, Morrison C, Tao C, Halder G. The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth. J Cell Sci 2009; 122:2351-9.
41. Bennett FC, Harvey KF. Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/ Hippo signaling pathway. Curr Biol 2006; 16:2101-10.
42. Tyler DM, Li W, Zhuo N, Pellock B, Baker NE. Genes affecting cell competition in Drosophila. Genetics 2007; 175:643-57.
43. Adachi-Yamada T, O'Connor MB. Morphogenetic apoptosis: a mechanism for correcting discontinuities in morphogen gradients. Dev Biol 2002; 251:74-90.
44. Adachi-Yamada T, O'Connor MB. Mechanisms for removal of developmentally abnormal cells: cell competition and morphogenetic apoptosis. J Biochem (Tokyo) 2004; 136:13-7.
45. Froldi F, Ziosi M, Garoia F, Pession A, Grzeschik NA, Bellosta P, et al. The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy. BMC Biol 2010; 8:33.
46. Gallant P. Myc, cell competition and compensatory proliferation. Cancer Res 2005; 65:6485-7.
47. Johnston LA. Competitive interactions between cells: death, growth and geography. Science 2009; 324:1679-82.
48. Szafranski P, Goode S. Basolateral junctions are sufficient to suppress epithelial invasion during Drosophila oogenesis. Dev Dyn 2007; 236:364-73.
49. Manfruelli P, Arquier N, Hanratty WP, Semeriva M. The tumor suppressor gene, lethal(2)giant larvae (1(2)g1), is required for cell shape change of epithelial cells during Drosophila development. Development 1996; 122:2283-94.
50. Goode S, Wei J, Kishore S. Novel spatiotemporal patterns of epithelial tumor invasion in Drosophila discs large egg chambers. Dev Dyn 2005; 232:855-64.
51. Ramet M, Lanot R, Zachary D, Manfruelli P. JNK signaling pathway is required for efficient wound healing in Drosophila. Dev Biol 2002; 241:145-56.
52. Weber U, Paricio N, Mlodzik M. Jun mediates Frizzled-induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye. Development 2000; 127:3619-29.
53. Menut L, Vaccari T, Dionne H, Hill J, Wu G, Bilder D. A mosaic genetic screen for Drosophila neoplastic tumor suppressor genes based on defective pupation. Genetics 2007; 177:1667-77.
54. Buttitta LA, Katzaroff AJ, Perez CL, de la Cruz A, Edgar BA. A double-assurance mechanism controls cell cycle exit upon terminal differentiation in Drosophila. Dev Cell 2007; 12:631-43.
55. Buttitta LA, Edgar BA. Mechanisms controlling cell cycle exit upon terminal differentiation. Curr Opin Cell Biol 2007; 19:697-704.
56. Baonza A, Freeman M. Control of cell proliferation in the Drosophila eye by Notch signaling. Dev Cell 2005; 8:529-39.
57. Firth LC, Baker NE. Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev Cell 2005; 8:541-51.
58. Brumby AM, Richardson HE. Using Drosophila melanogaster to map human cancer pathways. Nat Rev Cancer 2005; 5:626-39.
59. Uhlirova M, Bohmann D. JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila. EMBO J 2006; 25:5294-304.
60. Uhlirova M, Jasper H, Bohmann D. Non-cell-autonomous induction of tissue overgrowth by JNK/ Ras cooperation in a Drosophila tumor model. Proc Natl Acad Sci USA 2005; 102:13123-8.
61. Igaki T, Pagliarini RA, Xu T. Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila. Curr Biol 2006; 16:1139-46.
62. Bossuyt W, De Geest N, Aerts S, Leenaerts I, Marynen P, Hassan BA. The atonal proneural transcription factor links differentiation and tumor formation in Drosophila. PLoS Biol 2009; 7:40.
63. Zhu M, Xin T, Weng S, Gao Y, Zhang Y, Li Q, et al. Activation of JNK signaling links lgl mutations to disruption of the cell polarity and epithelial organization in Drosophila imaginal discs. Cell Res 2010; 20:242-5.
64. Kennedy NJ, Davis RJ. Role of JNK in tumor development. Cell Cycle 2003; 2:199-201.
65. Weston CR, Davis RJ. The JNK signal transduction pathway. Curr Opin Cell Biol 2007; 19:142-9.
66. Whitmarsh AJ, Davis RJ. Role of mitogen-activated protein kinase kinase 4 in cancer. Oncogene 2007; 26:3172-84.