Development and application of an LC-MS/MS method for measuring the effect of (partial) agonists on cAMP accumulation in vitro

Journal of Neuroscience Methods

Volumn 188, Issue 1, 2010, Pages 24-31

  Goutier, W ^a   Spaans, P A ^a   van der Neut, M A W ^a   McCreary, A C ^a   Reinders, J H ^a  

^a Solvay Pharmaceuticals Inc   (Netherlands)

Author keywords

ATP; CAMP; Dopamine D2; HILIC; LC MS; Partial agonist

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMPHOLYTE; BIFEPRUNOX; CYCLIC AMP; DOPAMINE; DOPAMINE 2 RECEPTOR STIMULATING AGENT; FORSKOLIN; HALOPERIDOL; LISURIDE; LY 741626; QUINPIROLE; ROPINIROLE; SULPIRIDE; TERGURIDE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; BIOACCUMULATION; CELL VIABILITY; CHO CELL; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROCESS OPTIMIZATION; QUALITY CONTROL; QUANTITATIVE STUDY; REPRODUCIBILITY; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; STANDARD; TANDEM MASS SPECTROMETRY; VALIDITY;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELLS, CULTURED; CHO CELLS; CHROMATOGRAPHY, LIQUID; CRICETINAE; CRICETULUS; CYCLIC AMP; DOPAMINE AGONISTS; RECEPTORS, DOPAMINE D2; TANDEM MASS SPECTROMETRY;

EID: 77950459263     PISSN: 01650270     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneumeth.2010.01.027     Document Type: Article

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