메뉴 건너뛰기




Volumn 43, Issue 10-11, 2010, Pages 843-850

Asymmetric dimethylarginine-a determinant of the effect of the high dose Simvastatin

Author keywords

Apolipoprotein; Asymmetric dimethylarginine; Flow mediated vasodilatation; Hypercholesterolemia; Low density lipoprotein; Nitric oxide; Nitric oxide synthase; Pleiotropic effect; Statins; Total homocysteine

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; BIOLOGICAL MARKER; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HOMOCYSTEINE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; N(G),N(G) DIMETHYLARGININE; SIMVASTATIN; ARGININE; DIMETHYLARGININE;

EID: 77955705037     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2010.04.054     Document Type: Article
Times cited : (2)

References (64)
  • 1
    • 1242341478 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA): a key regulator of nitric oxide synthase
    • Böger R.H., Vallance P., Cooke J.P. Asymmetric dimethylarginine (ADMA): a key regulator of nitric oxide synthase. Atherosclerosis 2003, 4(Suppl.4):1-3.
    • (2003) Atherosclerosis , vol.4 , Issue.SUPPL. 4 , pp. 1-3
    • Böger, R.H.1    Vallance, P.2    Cooke, J.P.3
  • 2
    • 33645501775 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA): a novel risk marker in cardiovascular medicine and beyond
    • Böger R.H. Asymmetric dimethylarginine (ADMA): a novel risk marker in cardiovascular medicine and beyond. Ann Med 2006, 38:126-136.
    • (2006) Ann Med , vol.38 , pp. 126-136
    • Böger, R.H.1
  • 3
    • 31344444441 scopus 로고    scopus 로고
    • ADMA:its role in vascular disease
    • Cooke J.P. ADMA:its role in vascular disease. Vasc Med 2005, 10:S11-S17.
    • (2005) Vasc Med , vol.10
    • Cooke, J.P.1
  • 4
    • 3142736452 scopus 로고    scopus 로고
    • Effect of simvastatin on endothelium-dependent vasorelaxation and endogenous nitric oxide synthase inhibitor
    • Jiang J., Jiang D., Tang Y., Li N., Deng H., Li Y. Effect of simvastatin on endothelium-dependent vasorelaxation and endogenous nitric oxide synthase inhibitor. Acta Pharmacol Sin 2004, 25:893-901.
    • (2004) Acta Pharmacol Sin , vol.25 , pp. 893-901
    • Jiang, J.1    Jiang, D.2    Tang, Y.3    Li, N.4    Deng, H.5    Li, Y.6
  • 5
    • 33747186695 scopus 로고    scopus 로고
    • ADMA Increases Arterial Stiffness and Decreases Cerebral Blood Flow in Humans
    • Kielstein J.T., Donnerstag F., Gasper S., et al. ADMA Increases Arterial Stiffness and Decreases Cerebral Blood Flow in Humans. Stroke 2006, 37:2024-2029.
    • (2006) Stroke , vol.37 , pp. 2024-2029
    • Kielstein, J.T.1    Donnerstag, F.2    Gasper, S.3
  • 6
    • 0034698038 scopus 로고    scopus 로고
    • LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells
    • Böger R.H., Sydow K., Borlak J., et al. LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells. Circ Res 2000, 87:99-105.
    • (2000) Circ Res , vol.87 , pp. 99-105
    • Böger, R.H.1    Sydow, K.2    Borlak, J.3
  • 7
    • 0033594888 scopus 로고    scopus 로고
    • Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase
    • Ito A., Tsao P.S., Adimoolam S., Kimoto M., Ogawa T., Cooke J.P. Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. Circulation 1999, 99:3092-3095.
    • (1999) Circulation , vol.99 , pp. 3092-3095
    • Ito, A.1    Tsao, P.S.2    Adimoolam, S.3    Kimoto, M.4    Ogawa, T.5    Cooke, J.P.6
  • 8
    • 31344473974 scopus 로고    scopus 로고
    • ADMA: an emerging cardiovascular risk factor
    • Böger R.H., Cooke J.P., Vallance P. ADMA: an emerging cardiovascular risk factor. Vasc Med 2005, 10(Suppl 1):S1-S2.
    • (2005) Vasc Med , vol.10 , Issue.SUPPL. 1
    • Böger, R.H.1    Cooke, J.P.2    Vallance, P.3
  • 9
    • 0344306684 scopus 로고    scopus 로고
    • Association of asymmetric dimethylarginine and endothelial dysfunction
    • Böger R.H. Association of asymmetric dimethylarginine and endothelial dysfunction. Clin Chem Lab Med 2003, 41:1467-1472.
    • (2003) Clin Chem Lab Med , vol.41 , pp. 1467-1472
    • Böger, R.H.1
  • 10
    • 33645501775 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA): a novel risk marker in cardiovascular medicine and beyond
    • Böger R.H. Asymmetric dimethylarginine (ADMA): a novel risk marker in cardiovascular medicine and beyond. Ann Med 2006, 38:126-136.
    • (2006) Ann Med , vol.38 , pp. 126-136
    • Böger, R.H.1
  • 11
    • 30044441986 scopus 로고    scopus 로고
    • Relation between plasma asymmetric dimethylarginine (ADMA) and risk factors for coronary artery disease
    • Wang J., Sim A.S., Wang X.L., Salonikas C., Naidoo D., Wilcken D.E.L. Relation between plasma asymmetric dimethylarginine (ADMA) and risk factors for coronary artery disease. Atherosclerosis 2006, 184:383-388.
    • (2006) Atherosclerosis , vol.184 , pp. 383-388
    • Wang, J.1    Sim, A.S.2    Wang, X.L.3    Salonikas, C.4    Naidoo, D.5    Wilcken, D.E.L.6
  • 12
    • 33947305131 scopus 로고    scopus 로고
    • ADMA is independently related to flow-mediated vasodilation in subjects at low cardiovascular risk European
    • Ardigo D., Stuehlinger M., Franzini L., et al. ADMA is independently related to flow-mediated vasodilation in subjects at low cardiovascular risk European. J Clin Invest 2007, 37:263-269.
    • (2007) J Clin Invest , vol.37 , pp. 263-269
    • Ardigo, D.1    Stuehlinger, M.2    Franzini, L.3
  • 13
    • 34548689666 scopus 로고    scopus 로고
    • Brachial artery flow-mediated dilation and asymmetrical dimethylarginine in the cardiovascular risk in young finns study
    • Juonala M., Viikari J., Alfthan G., et al. Brachial artery flow-mediated dilation and asymmetrical dimethylarginine in the cardiovascular risk in young finns study. Circulation 2007, 116:1367-1373.
    • (2007) Circulation , vol.116 , pp. 1367-1373
    • Juonala, M.1    Viikari, J.2    Alfthan, G.3
  • 14
    • 0032584177 scopus 로고    scopus 로고
    • Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors
    • Laufs U., La F., Plutzky J., Liao J.K. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation 1998, 97:1129-1135.
    • (1998) Circulation , vol.97 , pp. 1129-1135
    • Laufs, U.1    La, F.2    Plutzky, J.3    Liao, J.K.4
  • 15
    • 34250329234 scopus 로고    scopus 로고
    • Effects of atorvastatin therapy on hypercholesterolemic rabbits with respect to oxidative stress, nitric oxide pathway and homocysteine
    • Bolayirli I.M., Aslan M., Balci H., Altug T., Hacibekiroglu M., Seven A. Effects of atorvastatin therapy on hypercholesterolemic rabbits with respect to oxidative stress, nitric oxide pathway and homocysteine. Life Sci 2007, 81:121-127.
    • (2007) Life Sci , vol.81 , pp. 121-127
    • Bolayirli, I.M.1    Aslan, M.2    Balci, H.3    Altug, T.4    Hacibekiroglu, M.5    Seven, A.6
  • 16
    • 12244268005 scopus 로고    scopus 로고
    • Increased levels of asymmetric dimethylarginine in population at risk for atherosclerotic disease. Effects of pravastatin
    • Eid H.M., Eritsland J., Larsen J., Arnesen H., Seljeflot I. Increased levels of asymmetric dimethylarginine in population at risk for atherosclerotic disease. Effects of pravastatin. Atherosclerosis 2003, 166:279-284.
    • (2003) Atherosclerosis , vol.166 , pp. 279-284
    • Eid, H.M.1    Eritsland, J.2    Larsen, J.3    Arnesen, H.4    Seljeflot, I.5
  • 17
    • 3142736452 scopus 로고    scopus 로고
    • Effect of simvastatin on endothelium dependent vasorelaxation and endogenous nitric oxide synthase inhibitor
    • Jiang J., Jiang D., Tang Y., Li N., Deng H., Li Y. Effect of simvastatin on endothelium dependent vasorelaxation and endogenous nitric oxide synthase inhibitor. Acta Pharmacol Sin 2004, 25:893-901.
    • (2004) Acta Pharmacol Sin , vol.25 , pp. 893-901
    • Jiang, J.1    Jiang, D.2    Tang, Y.3    Li, N.4    Deng, H.5    Li, Y.6
  • 18
  • 19
    • 0037083163 scopus 로고    scopus 로고
    • Effects of Atorvastatin on oxidized low-density lipoprotein, low-density lipoprotein subfraction distribution and remnants lipoprotein in patients with mixed hyperlipoproteinemia
    • Sasaki S., Kuwahara N., Kunitomo K., et al. Effects of Atorvastatin on oxidized low-density lipoprotein, low-density lipoprotein subfraction distribution and remnants lipoprotein in patients with mixed hyperlipoproteinemia. Am J Cardiol 2002, 89:386-389.
    • (2002) Am J Cardiol , vol.89 , pp. 386-389
    • Sasaki, S.1    Kuwahara, N.2    Kunitomo, K.3
  • 20
    • 34548740746 scopus 로고    scopus 로고
    • Decreased plasma soluble RAGE in patients with hypercholesterolemia: Effects of statins
    • Santili F., Bucciarelli L., Noto D., et al. Decreased plasma soluble RAGE in patients with hypercholesterolemia: Effects of statins. Free Radic Biol Med 2007, 43:1255-1262.
    • (2007) Free Radic Biol Med , vol.43 , pp. 1255-1262
    • Santili, F.1    Bucciarelli, L.2    Noto, D.3
  • 21
    • 0037402473 scopus 로고    scopus 로고
    • Effects of Simvastatin and L-arginine on Vasodilation, Nitric Oxide Metabolites and Endogenous NOS Inhibitors in Hypercholesterolemic Subjects
    • Periera E.C., Bertolami M.C., Faludi A.A., Salem M., Bersch D., Abdalla D. Effects of Simvastatin and L-arginine on Vasodilation, Nitric Oxide Metabolites and Endogenous NOS Inhibitors in Hypercholesterolemic Subjects. Free Radic Res 2003, 37:529-536.
    • (2003) Free Radic Res , vol.37 , pp. 529-536
    • Periera, E.C.1    Bertolami, M.C.2    Faludi, A.A.3    Salem, M.4    Bersch, D.5    Abdalla, D.6
  • 22
    • 3142606890 scopus 로고    scopus 로고
    • Effect of rosuvastatin on plasma levels of asymmetric dimethylarginine in patients with hypercholesterolemia
    • Lu T.M., Ding Y.A., Leu H.B. Effect of rosuvastatin on plasma levels of asymmetric dimethylarginine in patients with hypercholesterolemia. Am J Cardiol 2004, 94:157-161.
    • (2004) Am J Cardiol , vol.94 , pp. 157-161
    • Lu, T.M.1    Ding, Y.A.2    Leu, H.B.3
  • 23
    • 3342927602 scopus 로고    scopus 로고
    • Atorvastatin restores endothelial function in normocholetserolemic smokers independent of changes in lowdensity lipoprotein
    • Beckman J.A., Liao J.K., Hurley S., Garret L.A., Chui D., Mitra D., et al. Atorvastatin restores endothelial function in normocholetserolemic smokers independent of changes in lowdensity lipoprotein. Circ Res 2004, 95:217-223.
    • (2004) Circ Res , vol.95 , pp. 217-223
    • Beckman, J.A.1    Liao, J.K.2    Hurley, S.3    Garret, L.A.4    Chui, D.5    Mitra, D.6
  • 24
    • 0033614802 scopus 로고    scopus 로고
    • Cholesterol reduction rapidly improves endothelial function after acute coronary syndromes: the RECIFE (Reduction of cholesterol in ischemia and function of the endothelium) trial
    • Dupuis J., Tardif J.C., Cernacek P., Theroux P. Cholesterol reduction rapidly improves endothelial function after acute coronary syndromes: the RECIFE (Reduction of cholesterol in ischemia and function of the endothelium) trial. Circulation 1999, 99:3227-3233.
    • (1999) Circulation , vol.99 , pp. 3227-3233
    • Dupuis, J.1    Tardif, J.C.2    Cernacek, P.3    Theroux, P.4
  • 25
    • 1442327759 scopus 로고    scopus 로고
    • The effects of atorvastatin on endothelial function in diabetes patients and subjects at risk for type 2 diabetes
    • Economodes P.A., Casselli A., Tiani E., Khaodhiar L., Horton E.S., Veves A. The effects of atorvastatin on endothelial function in diabetes patients and subjects at risk for type 2 diabetes. J Clin Endocrinol Metab 2004, 89:740-747.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 740-747
    • Economodes, P.A.1    Casselli, A.2    Tiani, E.3    Khaodhiar, L.4    Horton, E.S.5    Veves, A.6
  • 26
    • 0344563476 scopus 로고    scopus 로고
    • HMG CoA reductase inhibitors are related to improved systemic endothelial function in coronary artery disease
    • Jörvisalo M.J., Toikka J.O., Vasankari T., Mikkola J., Viikari J., Hartiala J., et al. HMG CoA reductase inhibitors are related to improved systemic endothelial function in coronary artery disease. Atherosclerosis 1999, 147:237-242.
    • (1999) Atherosclerosis , vol.147 , pp. 237-242
    • Jörvisalo, M.J.1    Toikka, J.O.2    Vasankari, T.3    Mikkola, J.4    Viikari, J.5    Hartiala, J.6
  • 27
    • 0033862040 scopus 로고    scopus 로고
    • Atorvastatin but not L-Arginine improves endothelial function in type diabetes mellitus: A doubleblind study
    • Mullen M.J., Wright D., Donald A.E., Thorne S., Thomson H., Deanfield J.E. Atorvastatin but not L-Arginine improves endothelial function in type diabetes mellitus: A doubleblind study. J Am Coll Cardiol 2000, 36:410-416.
    • (2000) J Am Coll Cardiol , vol.36 , pp. 410-416
    • Mullen, M.J.1    Wright, D.2    Donald, A.E.3    Thorne, S.4    Thomson, H.5    Deanfield, J.E.6
  • 28
    • 0032478236 scopus 로고    scopus 로고
    • Effects of atorvastatin monotherapy and simvastatin plus cholesteramine on arterial endothelial function in patients with severe primary hypercholesterolemia
    • Simons L.A., Sullivan D., Simons J., Celermajer D.S. Effects of atorvastatin monotherapy and simvastatin plus cholesteramine on arterial endothelial function in patients with severe primary hypercholesterolemia. Atherosclerosis 1998, 137:197-203.
    • (1998) Atherosclerosis , vol.137 , pp. 197-203
    • Simons, L.A.1    Sullivan, D.2    Simons, J.3    Celermajer, D.S.4
  • 29
    • 0030051944 scopus 로고    scopus 로고
    • Changes in flow-mediated brachial artery vasoactivity with lowering of desirable cholesterol levels in healthy middle-aged men
    • Vogel R.A., Correti M.C., Plotnick G.D. Changes in flow-mediated brachial artery vasoactivity with lowering of desirable cholesterol levels in healthy middle-aged men. Am J Cardiol 1996, 77:37-40.
    • (1996) Am J Cardiol , vol.77 , pp. 37-40
    • Vogel, R.A.1    Correti, M.C.2    Plotnick, G.D.3
  • 30
    • 0038115421 scopus 로고    scopus 로고
    • Correlates of endothelial function and their relationship with inflammation in patients with familial hypercholesterolemia
    • van Haelst P.L., van Doormaal J.J., Asselbergs F.W., van Roon A.M., Veeger N.J., Henneman M.M., et al. Correlates of endothelial function and their relationship with inflammation in patients with familial hypercholesterolemia. Clin Sci 2003, 104:627-632.
    • (2003) Clin Sci , vol.104 , pp. 627-632
    • van Haelst, P.L.1    van Doormaal, J.J.2    Asselbergs, F.W.3    van Roon, A.M.4    Veeger, N.J.5    Henneman, M.M.6
  • 31
    • 0033010123 scopus 로고    scopus 로고
    • Endothelial dysfunction is not reversed by simvastatin treatment in type 2 diabetes patients with hypercholesterolemia
    • Sheu W.H., Juang B.L., Chen Y.T., Lee W.J. Endothelial dysfunction is not reversed by simvastatin treatment in type 2 diabetes patients with hypercholesterolemia. Diabetes Care 1999, 22:1224-1225.
    • (1999) Diabetes Care , vol.22 , pp. 1224-1225
    • Sheu, W.H.1    Juang, B.L.2    Chen, Y.T.3    Lee, W.J.4
  • 33
    • 0037132672 scopus 로고    scopus 로고
    • Early statin therapy restores endothelial function in children with familial hypercholesterolemia
    • Jongh S., Lilien M.R., Roods J., Stroes E., Bakker H.D., Kastelein J. Early statin therapy restores endothelial function in children with familial hypercholesterolemia. J Am Coll Cardiol 2002, 40:2117-2121.
    • (2002) J Am Coll Cardiol , vol.40 , pp. 2117-2121
    • Jongh, S.1    Lilien, M.R.2    Roods, J.3    Stroes, E.4    Bakker, H.D.5    Kastelein, J.6
  • 34
    • 1242295337 scopus 로고    scopus 로고
    • Plasma asymmetric dimethylarginine modifies the effect of pravastatin on myocardial blood flow in young adults
    • Janatuinen T., Laakso J., Laaksonen R., Nuutila P., Lehtimaki T., Raitakari O.T., et al. Plasma asymmetric dimethylarginine modifies the effect of pravastatin on myocardial blood flow in young adults. Vasc Med 2003, 8:185-189.
    • (2003) Vasc Med , vol.8 , pp. 185-189
    • Janatuinen, T.1    Laakso, J.2    Laaksonen, R.3    Nuutila, P.4    Lehtimaki, T.5    Raitakari, O.T.6
  • 35
    • 34249824593 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine determines the improvement of endothelium-dependent vasodilatation by Simvastatin
    • Böger G.I., Rudolf T.K., Renke M., Schwedhelm E., Dumbadze E., Bieren A., et al. Asymmetric dimethylarginine determines the improvement of endothelium-dependent vasodilatation by Simvastatin. J Am Coll Cardiol 2007, 49:2274-2282.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 2274-2282
    • Böger, G.I.1    Rudolf, T.K.2    Renke, M.3    Schwedhelm, E.4    Dumbadze, E.5    Bieren, A.6
  • 36
    • 33750490459 scopus 로고    scopus 로고
    • Total plasma homocysteine in bulgarian population measured by high-performance liquid chromatography with fluorescent detection-comparison with fluorescence polarization immunoassay
    • Angelova E., Minkova G., Tsvetkova T. Total plasma homocysteine in bulgarian population measured by high-performance liquid chromatography with fluorescent detection-comparison with fluorescence polarization immunoassay. Clin Lab 2006, 52:527-533.
    • (2006) Clin Lab , vol.52 , pp. 527-533
    • Angelova, E.1    Minkova, G.2    Tsvetkova, T.3
  • 37
    • 0037116573 scopus 로고    scopus 로고
    • Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilatation of the brachial artery
    • Corretti M.C., Anderson T.J., Benjamin E.J., et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilatation of the brachial artery. J Am Coll Cardiol 2002, 39:257-265.
    • (2002) J Am Coll Cardiol , vol.39 , pp. 257-265
    • Corretti, M.C.1    Anderson, T.J.2    Benjamin, E.J.3
  • 38
    • 0026478022 scopus 로고
    • Non-invasive detection of endothelial dysfunction in children and adulst at risk of atherosclerosis
    • Celermajer D.S., Sorensen K.E., Gooch V.M., et al. Non-invasive detection of endothelial dysfunction in children and adulst at risk of atherosclerosis. Lancet 1992, 340:1111-1115.
    • (1992) Lancet , vol.340 , pp. 1111-1115
    • Celermajer, D.S.1    Sorensen, K.E.2    Gooch, V.M.3
  • 40
    • 0036076664 scopus 로고    scopus 로고
    • Simvastatin restores endothelial NO mediated vasorelaxation in large arteries after myocardial infarction
    • Bates K., Ruggeroli C.E., Goldman S., Gaballa M.A. Simvastatin restores endothelial NO mediated vasorelaxation in large arteries after myocardial infarction. Am J Physiol 2002, 283:H768-H775.
    • (2002) Am J Physiol , vol.283
    • Bates, K.1    Ruggeroli, C.E.2    Goldman, S.3    Gaballa, M.A.4
  • 41
    • 0035162842 scopus 로고    scopus 로고
    • Simvastatin preserves coronary endothelial function in hypercholesterolemia in the absence of lipid lowering
    • Wilson S.H., Simari R.D., Best P.J., et al. Simvastatin preserves coronary endothelial function in hypercholesterolemia in the absence of lipid lowering. Arterioscler Thromb Vasc Biol 2001, 21:122-128.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 122-128
    • Wilson, S.H.1    Simari, R.D.2    Best, P.J.3
  • 42
    • 33645683999 scopus 로고    scopus 로고
    • Simvastatin treatment improves endothelial function and increases fibrinolysis in patients with hypercholesterolemia
    • Guven G.S., Atalar E., Yavuz B., Beyazit Y., Kekilli M., Kilicarslan A., et al. Simvastatin treatment improves endothelial function and increases fibrinolysis in patients with hypercholesterolemia. J Natl Med Assoc 2006, 98:627-630.
    • (2006) J Natl Med Assoc , vol.98 , pp. 627-630
    • Guven, G.S.1    Atalar, E.2    Yavuz, B.3    Beyazit, Y.4    Kekilli, M.5    Kilicarslan, A.6
  • 43
    • 10744232622 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA) modulates endothelial function therapeutic implications
    • Böger R.H. Asymmetric dimethylarginine (ADMA) modulates endothelial function therapeutic implications. Vasc Med 2003, 8:149-151.
    • (2003) Vasc Med , vol.8 , pp. 149-151
    • Böger, R.H.1
  • 44
    • 0033594888 scopus 로고    scopus 로고
    • Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase
    • Ito A., Tsao P.S., Adimoolam S., Kimoto M., Ogawa T., Cooke J.P. Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. Circulation 1999, 99:3092-3095.
    • (1999) Circulation , vol.99 , pp. 3092-3095
    • Ito, A.1    Tsao, P.S.2    Adimoolam, S.3    Kimoto, M.4    Ogawa, T.5    Cooke, J.P.6
  • 45
    • 0034745613 scopus 로고    scopus 로고
    • Letter to the editor: high-dose simvastatin (80mg/day) decreases plasma concentrations of total homocysteine in patients with hypercholesterolemia
    • Lüftjohann D., Sigit J.I., Locatelli S., Bergmann K. Letter to the editor: high-dose simvastatin (80mg/day) decreases plasma concentrations of total homocysteine in patients with hypercholesterolemia. Atherosclerosis 2001, 155:265-266.
    • (2001) Atherosclerosis , vol.155 , pp. 265-266
    • Lüftjohann, D.1    Sigit, J.I.2    Locatelli, S.3    Bergmann, K.4
  • 46
    • 0347355493 scopus 로고    scopus 로고
    • Letter to the editor: lipid-lowering drugs and homocysteine a comparison between statins and other lipid-lowering drugs
    • Jankowski P., Kawecka-Jaszcz K. Letter to the editor: lipid-lowering drugs and homocysteine a comparison between statins and other lipid-lowering drugs. Atherosclerosis 2004, 172:191-194.
    • (2004) Atherosclerosis , vol.172 , pp. 191-194
    • Jankowski, P.1    Kawecka-Jaszcz, K.2
  • 47
    • 0037211997 scopus 로고    scopus 로고
    • Letter to the editor: statins and homocysteine
    • Miltiadous G., Papakostas J. Letter to the editor: statins and homocysteine. Atherosclerosis 2003, 166:199-200.
    • (2003) Atherosclerosis , vol.166 , pp. 199-200
    • Miltiadous, G.1    Papakostas, J.2
  • 48
    • 73549110255 scopus 로고    scopus 로고
    • Regulation of the ADMA-DDAH system in endothelial cells: a novel mechanism for the response element dinding proteins, SREBP1c and -2
    • Ivashchenko C.Y., Bradley B.T., Ao Z., Leiper J., Vallance P., Douglas J.G. Regulation of the ADMA-DDAH system in endothelial cells: a novel mechanism for the response element dinding proteins, SREBP1c and -2. Am J Physiol Heart Circ Physiol 2010, 298:H251-H258.
    • (2010) Am J Physiol Heart Circ Physiol , vol.298
    • Ivashchenko, C.Y.1    Bradley, B.T.2    Ao, Z.3    Leiper, J.4    Vallance, P.5    Douglas, J.G.6
  • 49
    • 49449118649 scopus 로고    scopus 로고
    • Short term fluvastatin treatment lowers serum asymmetric dimethylarginine levels in patients with metabolic syndrome
    • Oguz A., Uzunlulu M. Short term fluvastatin treatment lowers serum asymmetric dimethylarginine levels in patients with metabolic syndrome. Int Heart J 2008, 49:303-311.
    • (2008) Int Heart J , vol.49 , pp. 303-311
    • Oguz, A.1    Uzunlulu, M.2
  • 50
    • 0034687141 scopus 로고    scopus 로고
    • Angiogenesis is impaired by hypercholesterolemia: role of asymmetric dimethylarginine
    • Jang J.J., Ho H.K., Kwan H.H., Fajardo L.F., Cooke J.P. Angiogenesis is impaired by hypercholesterolemia: role of asymmetric dimethylarginine. Circulation 2000, 102:1414-1419.
    • (2000) Circulation , vol.102 , pp. 1414-1419
    • Jang, J.J.1    Ho, H.K.2    Kwan, H.H.3    Fajardo, L.F.4    Cooke, J.P.5
  • 51
    • 3142590235 scopus 로고    scopus 로고
    • Improvement of endothelium-dependent vasodilation by simvastatin is potentiated by combination with l-arginine in patients with elevated asymmetric dimethylarginine levels
    • Böger G.I., Maas R., Schwedhelm E., Bierend A., Benndorf R., Kastner M., et al. Improvement of endothelium-dependent vasodilation by simvastatin is potentiated by combination with l-arginine in patients with elevated asymmetric dimethylarginine levels. J Am Coll Cardiol 2004, 43:525A. (Suppl.).
    • (2004) J Am Coll Cardiol , vol.43 , Issue.SUPPL
    • Böger, G.I.1    Maas, R.2    Schwedhelm, E.3    Bierend, A.4    Benndorf, R.5    Kastner, M.6
  • 52
    • 54249118627 scopus 로고    scopus 로고
    • Relationship of asymmetric dimethylarginine with flow-mediated dilation in subjects with newly detected severe hypercholesterolemia
    • Vladimirova-Kitova L.G., Deneva T., Angelova E., Nikolov F., Marinov B., Mateva N. Relationship of asymmetric dimethylarginine with flow-mediated dilation in subjects with newly detected severe hypercholesterolemia. Clin Physiol Funct Imaging 2008, 28:417-425.
    • (2008) Clin Physiol Funct Imaging , vol.28 , pp. 417-425
    • Vladimirova-Kitova, L.G.1    Deneva, T.2    Angelova, E.3    Nikolov, F.4    Marinov, B.5    Mateva, N.6
  • 53
    • 0242322346 scopus 로고    scopus 로고
    • Asymmetric dimethylagrinine (ADMA): a novel risk factor for endothelial dysfunction. Its role in hypercholesterolemia
    • Böger R.H., Bode-Böger S.M., Szuba A., et al. Asymmetric dimethylagrinine (ADMA): a novel risk factor for endothelial dysfunction. Its role in hypercholesterolemia. Circulation 1998, 98:1842-1847.
    • (1998) Circulation , vol.98 , pp. 1842-1847
    • Böger, R.H.1    Bode-Böger, S.M.2    Szuba, A.3
  • 54
    • 70349969749 scopus 로고    scopus 로고
    • Intima-media thickness and flow mediated vasodilation in asymptomatic subjects with newly detected severe hypercholesterolemia
    • Vladimirova-Kitova L., Terzieva D., Marinov B. Intima-media thickness and flow mediated vasodilation in asymptomatic subjects with newly detected severe hypercholesterolemia. Echocardiography 2009, 26(9):1060-1068.
    • (2009) Echocardiography , vol.26 , Issue.9 , pp. 1060-1068
    • Vladimirova-Kitova, L.1    Terzieva, D.2    Marinov, B.3
  • 56
    • 8644269701 scopus 로고    scopus 로고
    • Pharmacogenetics of HMG-CoA reductase inhibitors: exploring the potential for genotype-based individualization of coronary heart disease management
    • Kajinami K., Takekoshia N., Brousseau M.E., Schaefer E.J. Pharmacogenetics of HMG-CoA reductase inhibitors: exploring the potential for genotype-based individualization of coronary heart disease management. Atherosclerosis 2004, 177:219-234.
    • (2004) Atherosclerosis , vol.177 , pp. 219-234
    • Kajinami, K.1    Takekoshia, N.2    Brousseau, M.E.3    Schaefer, E.J.4
  • 57
    • 0033551539 scopus 로고    scopus 로고
    • Simvastatin preserves the ischemic-reperfused myocardium in normocholesterolemic rat hearts
    • Lefer A.M., Campbell B., Shin Y.K., et al. Simvastatin preserves the ischemic-reperfused myocardium in normocholesterolemic rat hearts. Circulation 1999, 100:178-184.
    • (1999) Circulation , vol.100 , pp. 178-184
    • Lefer, A.M.1    Campbell, B.2    Shin, Y.K.3
  • 58
    • 0035380624 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibition protects the diabetic myocardium from ischemia-reperfusion injury
    • Lefer D.J., Scalia R., Jones S.P., et al. HMG-CoA reductase inhibition protects the diabetic myocardium from ischemia-reperfusion injury. FASEB J 2001, 15:1454-1456.
    • (2001) FASEB J , vol.15 , pp. 1454-1456
    • Lefer, D.J.1    Scalia, R.2    Jones, S.P.3
  • 59
    • 0034006811 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by l-arginine after chronic statin treatment
    • Yamada M., Huang Z., Dalkara T., et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by l-arginine after chronic statin treatment. J Cereb Blood Flow Metab 2000, 20:709-717.
    • (2000) J Cereb Blood Flow Metab , vol.20 , pp. 709-717
    • Yamada, M.1    Huang, Z.2    Dalkara, T.3
  • 60
    • 0033532524 scopus 로고    scopus 로고
    • A HMG-CoA reductase inhibitor improved regression of atherosclerosis in the rabbit aorta without affecting serum lipid levels: possible relevance of up-regulation of endothelial NO synthase mRNA
    • Kano H., Hayashi T., Sumi D., et al. A HMG-CoA reductase inhibitor improved regression of atherosclerosis in the rabbit aorta without affecting serum lipid levels: possible relevance of up-regulation of endothelial NO synthase mRNA. Biochem Biophys Res Commun 1999, 259:414-419.
    • (1999) Biochem Biophys Res Commun , vol.259 , pp. 414-419
    • Kano, H.1    Hayashi, T.2    Sumi, D.3
  • 61
    • 0346736491 scopus 로고    scopus 로고
    • Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells
    • Hernandez-Perera O., Perez-Sala D., Navarro-Antolin J., et al. Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells. J Clin Invest 1998, 101:2711-2719.
    • (1998) J Clin Invest , vol.101 , pp. 2711-2719
    • Hernandez-Perera, O.1    Perez-Sala, D.2    Navarro-Antolin, J.3
  • 62
    • 54249144978 scopus 로고    scopus 로고
    • How to improve primary prevention in asymptomatic high risk subjects
    • SUPPL. J
    • Favre A., Monpere C., Voyer C., et al. How to improve primary prevention in asymptomatic high risk subjects. Eur Heart J 2004, 6:J59-J63. Suppl J.
    • (2004) Eur Heart J , vol.6
    • Favre, A.1    Monpere, C.2    Voyer, C.3
  • 63
    • 15944393211 scopus 로고    scopus 로고
    • Under-treated high risk patients: identifying patients in high-risk subgroup and treating them to LDL targets
    • SUPPL A
    • Schuster H. Under-treated high risk patients: identifying patients in high-risk subgroup and treating them to LDL targets. Eur Heart J 2005, 7:20-28. Suppl A.
    • (2005) Eur Heart J , vol.7 , pp. 20-28
    • Schuster, H.1
  • 64
    • 0033637470 scopus 로고    scopus 로고
    • Endothelial dysfunction in hypercholesterolemia-mechanisms, pathophysiological importance and therapeutic interventions
    • Landmesser U., Hornig B., Drexler H. Endothelial dysfunction in hypercholesterolemia-mechanisms, pathophysiological importance and therapeutic interventions. Semin Thromb Hemost 2000, 26:529-537.
    • (2000) Semin Thromb Hemost , vol.26 , pp. 529-537
    • Landmesser, U.1    Hornig, B.2    Drexler, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.