Effects of cellular iron deficiency on the formation of vascular endothelial growth factor and angiogenesis. Iron deficiency and angiogenesis

Cancer Cell International

Volumn 10, Issue , 2010, Pages

  Eckard, Jonathan ^a   Dai, Jisen ^a   Wu, Jing ^a   Jian, Jinlong ^a   Yang, Qing ^a   Chen, Haobin ^a   Costa, Max ^a   Frenkel, Krystyna ^a   Huang, Xi ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD71 ANTIGEN; DEFEROXAMINE; FERRITIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IRON; IRON DERIVATIVE; IRON REGULATORY FACTOR; LOW MOLECULAR WEIGHT IRON; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER RECURRENCE; CELL STRAIN; CELL STRAIN HEPG2; CELL STRAIN MCF 7; CELL STRAIN MDA MB 231; COCULTURE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPOXIA; IN VITRO STUDY; IRON CHELATION; IRON DEFICIENCY; IRON THERAPY; MOUSE; NONHUMAN; NUDE MOUSE; PATHOPHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN BINDING; PROTEIN SYNTHESIS; RISK FACTOR; RNA INTERFERENCE; TUMOR XENOGRAFT; WESTERN BLOTTING;

EID: 77955701147     PISSN: None     EISSN: 14752867     Source Type: Journal    
DOI: 10.1186/1475-2867-10-28     Document Type: Article

References (49)

1. Casalini P, Carcangiu ML, Tammi R, Auvinen P, Kosma VM, Valagussa P, Greco M, Balsari A, Menard S, Tagliabue E. Two distinct local relapse subtypes in invasive breast cancer: effect on their prognostic impact. Clin Cancer Res 2008, 14:25-31. 10.1158/1078-0432.CCR-07-0450, 18172248.
2. Klauber-DeMore N. Tumor biology of breast cancer in young women. Breast Dis 2005, 23:9-15.
3. Jemal A, Ward E, Thun MJ. Recent trends in breast cancer incidence rates by age and tumor characteristics among U.S. women. Breast Cancer Res 2007, 9:R28. 10.1186/bcr1672, 1929089, 17477859.
4. Ali MA, Akhmedkhanov A, Zeleniuch-Jaquotte A, Toniolo P, Frenkel K, Huang X. Reliability of serum iron, ferritin, nitrite, and association with risk of renal cancer in women. Cancer Det Prev 2003, 27:116-121.
5. Atwood CS, Meethal SV, Liu T, Wilson AC, Gallego M, Smith MA, Bowen RL. Dysregulation of the hypothalamic-pituitary-gonadal axis with menopause and andropause promotes neurodegenerative senescence. J Neuropathol Exp Neurol 2005, 64:93-103.
6. Chakraborty TR, Gore AC. Aging-related changes in ovarian hormones, their receptors, and neuroendocrine function. Exp Biol Med (Maywood) 2004, 229:977-987.
7. Zimmermann MB, Hurrell RF. Nutritional iron deficiency. Lancet 2007, 370:511-520. 10.1016/S0140-6736(07)61235-5, 17693180.
8. Cavill I, Auerbach M, Bailie GR, Barrett-Lee P, Beguin Y, Kaltwasser P, Littlewood T, Macdougall IC, Wilson K. Iron and the anaemia of chronic disease: a review and strategic recommendations. Curr Med Res Opin 2006, 22:731-737. 10.1185/030079906X100096, 16684434.
9. Hercberg S, Preziosi P, Galan P. Iron deficiency in Europe. Public Health Nutr 2001, 4:537-545. 10.1079/PHN2001139, 11683548.
10. Weiss G, Gordeuk VR. Benefits and risks of iron therapy for chronic anaemias. Eur J Clin Invest 2005, 35(Suppl 3):36-45. 10.1111/j.1365-2362.2005.01529.x, 16281957.
11. Pantopoulos K. Iron metabolism and the IRE/IRP regulatory system: an update. Ann N Y Acad Sci 2004, 1012:1-13. 10.1196/annals.1306.001, 15105251.
12. Rouault TA. The role of iron regulatory proteins in mammalian iron homeostasis and disease. Nat Chem Biol 2006, 2:406-414. 10.1038/nchembio807, 16850017.
13. Muckenthaler MU, Galy B, Hentze MW. Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network. Annu Rev Nutr 2008, 28:197-213. 10.1146/annurev.nutr.28.061807.155521, 18489257.
14. Recalcati S, Minotti G, Cairo G. Iron regulatory proteins: from molecular mechanisms to drug development. Antioxid Redox Signal 2010,
15. Dongiovanni P, Valenti L, Ludovica Fracanzani A, Gatti S, Cairo G, Fargion S. Iron depletion by deferoxamine up-regulates glucose uptake and insulin signaling in hepatoma cells and in rat liver. Am J Pathol 2008, 172:738-747. 10.2353/ajpath.2008.070097, 2258266, 18245813.
16. Salnikow K, Donald SP, Bruick RK, Zhitkovich A, Phang JM, Kasprzak KS. Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress. J Biol Chem 2004, 279:40337-40344. 10.1074/jbc.M403057200, 15271983.
17. Bertout JA, Patel SA, Simon MC. The impact of O2 availability on human cancer. Nat Rev Cancer 2008, 8:967-975. 10.1038/nrc2540, 18987634.
18. Huang X. Does iron have a role in breast cancer?. Lancet Oncol 2008, 9:803-807. 10.1016/S1470-2045(08)70200-6, 2577284, 18672216.
19. Han W, Kim SW, Park IA, Kang D, Kim SW, Youn YK, Oh SK, Choe KJ, Noh DY. Young age: an independent risk factor for disease-free survival in women with operable breast cancer. BMC Cancer 2004, 4:82. 10.1186/1471-2407-4-82, 545947, 15546499.
20. Vaupel P, Mayer A, Briest S, Hockel M. Hypoxia in breast cancer: role of blood flow, oxygen diffusion distances, and anemia in the development of oxygen depletion. Adv Exp Med Biol 2005, 566:333-342. full_text, 16594170.
21. Kang GS, Li Q, Chen H, Costa M. Effect of metal ions on HIF-1alpha and Fe homeostasis in human A549 cells. Mutat Res 2006, 610:48-55.
22. Cavalieri E, Frenkel K, Liehr JG, Rogan E, Roy D. Estrogens as endogenous genotoxic agents--DNA adducts and mutations. J Natl Cancer Inst Monogr 2000, 75-93.
23. Rennert G, Bisland-Naggan S, Barnett-Griness O, Bar-Joseph N, Zhang S, Rennert HS, Narod SA. Clinical outcomes of breast cancer in carriers of BRCA1 and BRCA2 mutations. N Engl J Med 2007, 357:115-123. 10.1056/NEJMoa070608, 17625123.
24. Russo J, Hasan Lareef M, Balogh G, Guo S, Russo IH. Estrogen and its metabolites are carcinogenic agents in human breast epithelial cells. J Steroid Biochem Mol Biol 2003, 87:1-25. 10.1016/S0960-0760(03)00390-X, 14630087.
25. Gasparini G. Prognostic value of vascular endothelial growth factor in breast cancer. Oncologist 2000, 5(Suppl 1):37-44. 10.1634/theoncologist.5-suppl_1-37, 10804090.
26. Huang X. Iron overload and its association with cancer risk in humans: evidence for iron as a carcinogenic metal. Mutat Res 2003, 533:153-171.
27. Hardman WE, Barnes CJ, Knight CW, Cameron IL. Effects of iron supplementation and ET-18-OCH3 on MDA-MB 231 breast carcinomas in nude mice consuming a fish oil diet. Br J Cancer 1997, 76:347-354. 2224052, 9252202.
28. Ilsley JN, Leung SF, Belinsky GS, Guda K, Zhang Q, Huang X, Blumberg JB, Milbury PE, Roberts Ii LJ, Stevens RG, Rosenberg DW. Dietary iron promotes azoxymethane-induced colon tumors in mice. Nutr Cancer 2004, 49:162-169. 10.1207/s15327914nc4902_7, 15489209.
29. Thompson HJ, Kennedy K, Witt M, Juzefyk J. Effect of dietary iron deficiency or excess on the induction of mammary carcinogenesis by 1-methyl-1-nitrosourea. Carcinogenesis 1991, 12:111-114. 10.1093/carcin/12.1.111, 1988169.
30. Weinberg ED. Iron in neoplastic disease. Nutr Cancer 1983, 4:223-233. 10.1080/01635588209513761, 6302639.
31. Andrews NC, Schmidt PJ. Iron homeostasis. Annu Rev Physiol 2007, 69:69-85. 10.1146/annurev.physiol.69.031905.164337, 17014365.
32. Ganz T, Nemeth E. Regulation of iron acquisition and iron distribution in mammals. Biochim Biophys Acta 2006, 1763:690-699. 10.1016/j.bbamcr.2006.03.014, 16790283.
33. Lee GY, Kenny PA, Lee EH, Bissell MJ. Three-dimensional culture models of normal and malignant breast epithelial cells. Nat Methods 2007, 4:359-365. 10.1038/nmeth1015, 17396127.
34. Semenza GL. Hypoxia-inducible factor 1 and cancer pathogenesis. IUBMB Life 2008, 60:591-597. 10.1002/iub.93, 18506846.
35. Guo P, Fang Q, Tao HQ, Schafer CA, Fenton BM, Ding I, Hu B, Cheng SY. Overexpression of vascular endothelial growth factor by MCF-7 breast cancer cells promotes estrogen-independent tumor growth in vivo. Cancer Res 2003, 63:4684-4691.
36. Jiang XP, Elliott RL, Head JF. Manipulation of iron transporter genes results in the suppression of human and mouse mammary adenocarcinomas. Anticancer Res 2010, 30:759-765.
37. Jones DT, Trowbridge IS, Harris AL. Effects of transferrin receptor blockade on cancer cell proliferation and hypoxia-inducible factor function and their differential regulation by ascorbate. Cancer Res 2006, 66:2749-2756. 10.1158/0008-5472.CAN-05-3857, 16510596.
38. Gerald D, Berra E, Frapart YM, Chan DA, Giaccia AJ, Mansuy D, Pouyssegur J, Yaniv M, Mechta-Grigoriou F. JunD reduces tumor angiogenesis by protecting cells from oxidative stress. Cell 2004, 118:781-794. 10.1016/j.cell.2004.08.025, 15369676.
39. Semenza GL. Hypoxia-inducible factor 1 (HIF-1) pathway. Sci STKE 2007, 2007:cm8. 10.1126/stke.4072007cm8, 17925579.
40. Robach P, Cairo G, Gelfi C, Bernuzzi F, Pilegaard H, Vigano A, Santambrogio P, Cerretelli P, Calbet JA, Moutereau S, Lundby C. Strong iron demand during hypoxia-induced erythropoiesis is associated with down-regulation of iron-related proteins and myoglobin in human skeletal muscle. Blood 2007, 109:4724-4731. 10.1182/blood-2006-08-040006, 17311997.
41. Peyssonnaux C, Zinkernagel AS, Schuepbach RA, Rankin E, Vaulont S, Haase VH, Nizet V, Johnson RS. Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J Clin Invest 2007, 117:1926-1932. 10.1172/JCI31370, 1884690, 17557118.
42. Sanchez M, Galy B, Muckenthaler MU, Hentze MW. Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency. Nat Struct Mol Biol 2007, 14:420-426. 10.1038/nsmb1222, 17417656.
43. Semenza GL. Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends Mol Med 2001, 7:345-350. 10.1016/S1471-4914(01)02090-1, 11516994.
44. Peyssonnaux C, Nizet V, Johnson RS. Role of the hypoxia inducible factors HIF in iron metabolism. Cell Cycle 2008, 7:28-32.
45. Chen CL, Hsieh YT, Chen HC. Phosphorylation of adducin by protein kinase Cdelta promotes cell motility. J Cell Sci 2007, 120:1157-1167. 10.1242/jcs.03408, 17341583.
46. Rothenberger S, Mullner EW, Kuhn LC. The mRNA-binding protein which controls ferritin and transferrin receptor expression is conserved during evolution. Nucleic Acids Res 1990, 18:1175-1179. 10.1093/nar/18.5.1175, 330432, 2157191.
47. Wu J, Eckard J, Chen H, Costa M, Frenkel K, Huang X. Altered iron homeostasis involvement in arsenite-mediated cell transformation. Free Radic Biol Med 2006, 40:444-452. 10.1016/j.freeradbiomed.2005.08.035, 16443159.
48. Ali A, Zhang Q, Dai J, Huang X. Calcein as a fluorescent iron chemosensor for the determination of low molecular weight iron in biological fluids. Biometals 2003, 16:285-293. 10.1023/A:1020642808437, 12572687.
49. Zhang Q, Huang X. Induction of ferritin and lipid peroxidation by coal samples with different prevalence of coal workers' pneumoconiosis: role of iron in the coals. Am J Ind Med 2002, 42:171-179. 10.1002/ajim.10101, 12210686.