Formulation and process considerations affecting the stability of solid dosage forms formulated with methacrylate copolymers

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 47, Issue 1, 1999, Pages 15-25

  Petereit, Hans Ulrich ^a   Weisbrod, Wolfgang ^a  

^a Rohm GmbH   (Germany)

Author keywords

Methacrylate copolymers; Pharmaceutical technology; Solid dosage forms

Indexed keywords

ACETYLSALICYLIC ACID; ACYLGLYCEROL; AMINOPHYLLINE; BISACODYL; CHLORPHENIRAMINE MALEATE; CITRIC ACID; CITRIC ACID TRIETHYL ESTER; COPOLYMER; DICLOFENAC; ERYTHROMYCIN; ETHAMBUTOL; EUDRAGIT; EUDRAGIT E 100; EUDRAGIT RS; GELATIN; HORMONE; IBUPROFEN; ISONIAZID; KAOLIN; MESALAZINE; METHYLENE BLUE; MINERAL; PARACETAMOL; PHENYLPROPANOLAMINE; PLACEBO; PLASTICIZER; POLYMETHACRYLIC ACID DERIVATIVE; POTASSIUM CHLORIDE; PREDNISOLONE; PROPRANOLOL; QUINIDINE SULFATE; SPIRAMYCIN; THEOPHYLLINE; TRIMEBUTINE; UNCLASSIFIED DRUG; VALPROIC ACID;

DIFFERENTIAL SCANNING CALORIMETRY; DRUG COATING; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG IMPURITY; DRUG INTERACTION; DRUG PACKAGING; DRUG STABILITY; ENTERIC COATED TABLET; GARLIC; HUMIDITY; SHORT SURVEY; STORAGE; TEMPERATURE;

EID: 0033018174     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(98)00083-6     Document Type: Review

References (9)

1. K. Lehmann, H.-U. Petereit, Stability of aqueous polymethacrylate dispersions and films for controlled release, AAPS Seventh Annual Meeting, San Antonio, TX, 18 November, 1992.
2. B.C. Lippold, B.H. Lippold, Physicochemical properties of poly(methacrylic acid) derivatives. II. Hydrolytic reactions, ion exchange and dissociation properties, Pharm. Ind. 35 (1973) 854.
3. K. Peck, E.A. Schmitt, D. Raymond, Compatibility of enteric polymers and an acid-labile macrolid by isothermal calorimetry and HPLC: comparison of predicted interactions with actual formulation-stability results, AAPS Annual Meeting and Exhibition, Boston, MA 1997.
4. J.C. Gutierrez-Rocca, J.W. McGinity, Influence of aging on the physical-mechanical properties of acrylic resin films cast from aqueous dispersions and organic solutions, Drug Dev. Ind. Pharm. 19 (1993) 315-332.
5. K. Lehmann, H.-U. Petereit, Filmüberzüge auf Basis wäßriger Polymethacrylat-Dispersionen mit verzögertem Zerfall im Darmbereich, Pharm. Ind. 55 (1993) 615-618.
6. K. Lehmann, H.-U. Petereit, Enteric coatings and pH-controlled dissolution in the intestine, Glatt Symposium '93, Dresden 1993.
7. K. Lehmann, Assessment of polymethacrylate coatings (pH-dependent and permeable Polymers), AAPS/FDA/USP Workshop, Arlington, VA, 1992.
8. K. Lehmann, Wäßrige Überzüge auf festen Arzneiformen, APV Sympposium No. 549, 1991.
9. P.H. List, G. Laun, Zusammenhang zwischen Lösungsmittelresten und Permeabilität von EUDRAGIT L-Filmen, Pharm. Ind. 42 (1980) 399-401.