Guanidinylated neomycin mediates heparan sulfate-dependent transport of active enzymes to lysosomes

Molecular Therapy

Volumn 18, Issue 7, 2010, Pages 1268-1274

  Sarrazin, Stéphane ^a   Wilson, Beth ^a   Sly, William S ^b   Tor, Yitzhak ^a   Esko, Jeffrey D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLUCURONIDASE; GUANIDINYLATED NEOMYCIN; HEPARAN SULFATE; LEVO IDURONIDASE; LYSOSOME ENZYME; NEOMYCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; BIOTINYLATION; CELL COMPARTMENTALIZATION; CONJUGATION; ENDOCYTOSIS; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME REPLACEMENT; ENZYME SPECIFICITY; ENZYME STRUCTURE; FIBROBLAST; GENE DELIVERY SYSTEM; LYSOSOME; NONHUMAN;

ANIMALS; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; ENDOCYTOSIS; GLUCURONIDASE; GLYCOSAMINOGLYCANS; HEPARITIN SULFATE; HUMANS; IDURONIDASE; LYSOSOMES; MICROSCOPY, FLUORESCENCE; MOLECULAR STRUCTURE; NEOMYCIN; QUANTUM DOTS;

EID: 77955682534     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2010.78     Document Type: Article

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