The structural intolerance of the PrP α-fold for polar substitution of the helix-3 methionines

Cellular and Molecular Life Sciences

Volumn 67, Issue 16, 2010, Pages 2825-2838

  Lisa, Silvia ^a   Meli, Massimiliano ^b   Cabello, Gema ^a   Gabizon, Ruth ^c   Colombo, Giorgio ^b   Gasset, María ^a  

^a INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

^b CNR   (Italy)

^c HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Amyloids; Methionine oxidation; Prion protein conversion; Protein conformational switches

Indexed keywords

METHIONINE; PRION PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; ATOMIC FORCE MICROSCOPY; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HYDROPHOBICITY; LIGHT SCATTERING; MOLECULAR DYNAMICS; OXIDATION REDUCTION STATE; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN MODIFICATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; THERMOSTABILITY;

AMINO ACID SUBSTITUTION; CIRCULAR DICHROISM; DNA PRIMERS; GENETIC VARIATION; HOMOSERINE; HUMANS; METHIONINE; MODELS, MOLECULAR; NORLEUCINE; PRION DISEASES; PRIONS; PROTEIN CONFORMATION; PROTEIN FOLDING;

EID: 77955680774     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-010-0363-1     Document Type: Article

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