Hypoxia and preeclampsia: Increased expression of urocortin 2 and urocortin 3

Reproductive Sciences

Volumn 17, Issue 9, 2010, Pages 833-843

  Imperatore, Alberto ^a,b   Rolfo, Alessandro ^c   Petraglia, Felice ^b   Challis, John Rg ^a   Caniggia, Isabella ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF SIENA   (Italy)

^c MOUNT SINAI HOSPITAL   (Canada)

Author keywords

hypoxia; hypoxia inducible factor; placenta; preeclampsia; urocortin 2; urocortin 3

Indexed keywords

DIMETHYLOXALYLGLYCINE; GLYCINE DERIVATIVE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; UNCLASSIFIED DRUG; UROCORTIN II; UROCORTIN III;

ADULT; ARTICLE; CELL HYPOXIA; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FIRST TRIMESTER PREGNANCY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; OXYGEN TENSION; PATHOPHYSIOLOGY; PLACENTA DEVELOPMENT; PLACENTA VILLUS; PREECLAMPSIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TROPHOBLAST;

ADULT; AMINO ACIDS, DICARBOXYLIC; CASE-CONTROL STUDIES; CELL HYPOXIA; CELLS, CULTURED; CORTICOTROPIN-RELEASING HORMONE; FEMALE; GESTATIONAL AGE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; OXIDATIVE STRESS; OXYGEN; PLACENTA; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY TRIMESTER, FIRST; PROTEIN STABILITY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TISSUE CULTURE TECHNIQUES; TROPHOBLASTS; UP-REGULATION; UROCORTINS;

EID: 77955676942     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719110373147     Document Type: Article

References (39)

1. Hsu SY, Hsueh AJ Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. Nat Med. 2001 ; 7 (5). 605-611.
2. Lewis K., Li C., Perrin MH, et al. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Proc Natl Acad Sci U S A. 2001 ;19; 98 (13). 7570-7575.
3. Reyes TM, Lewis K., Perrin MH, et al. Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Proc Natl Acad Sci U S A. 2001 ; 98 (5). 2843-2848.
4. Wetzka B., Sehringer B., Schäfer WR, et al. Expression patterns of CRH, CRH receptors, and CRH binding protein in human gestational tissue at term. Exp Clin Endocrinol Diabetes. 2003 ; 111 (3). 154-161.
5. Imperatore A., Florio P., Torres PB, et al. Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes. Am J Obstet Gynecol. 2006 ; 195 (1). 288-295.
6. Janatpour MJ, Utset MF, Cross JC, et al. A repertoire of differentially expressed transcription factors that offers insight into mechanisms of human cytotrophoblast differentiation. Dev Genet. 1999 ; 25 (2). 146-157.
7. Kingdom JC, Kaufmann P., Jauniaux E. Oxygen and placental vascular development. Adv Exp Med Biol. 2000 ; 474: 259-275.
8. Rodesch F., Simon P., Donner C., Jauniaux E. Oxygen measurements in endometrial and trophoblastic tissues during early pregnancy. Obstet Gynecol. 1992 ; 80 (2). 283-285.
9. Hung TH, Charnock-Jones DS, Skepper JN, Burton GJ Secretion of tumor necrosis factor-alpha from human placental tissues induced by hypoxia-reoxygenation causes endothelial cell activation in vitro: a potential mediator of the inflammatory response in preeclampsia. Am J Pathol. 2004 ; 164 (3). 1049-1061.
10. Genbacev O., Joslin R., Damsky CH, Polliotti BM, Fisher SJ Hypoxia alters early gestation human cytotrophoblast differentiation/invasion in vitro and models the placental defects that occur in preeclampsia. J Clin Invest. 1996 ; 97 (2). 540-550.
11. Caniggia I., Winter J., Lye SJ, Post M. Oxygen and placental development during the first trimester: implications for the pathophysiology of pre-eclampsia. Placenta. 2000 ; 21 (suppl A). S25 - S30.
12. Roberts JM, Hubel CA Is oxidative stress the link in the two-stage model of pre-eclampsia ? Lancet. 1999 ; 354 (9181). 788-789.
13. Walker JJ Pre-eclampsia. Lancet. 2000 ; 356 (9237). 1260-1265 [Review].
14. Caniggia I., Mostachfi H., Winter J., et al. Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3). J Clin Invest. 2000 ; 105 (5). 577-587.
15. Metzen E., Ratcliffe PJ HIF hydroxylation and cellular oxygen sensing. Biol Chem. 2004 ; 385 (3-4). 223-230.
16. Ten VS, Pinsky DJ Endothelial response to hypoxia: physiologic adaptation and pathologic dysfunction. Curr Opin Crit Care. 2002 ; 8 (3). 242-250.
17. Chen A., Blount A., Vaughan J., Brar B., Vale W. Urocortin II gene is highly expressed in mouse skin and skeletal muscle tissues: localization, basal expression in corticotropin-releasing factor receptor (CRFR) 1- and CRFR2-null mice, and regulation by glucocorticoids. Endocrinology. 2004 ; 145 (5). 2445-2457.
18. Jain V., Longo M., Ali M., Saade GR, Chwalisz K., Garfield RE Expression of receptors for corticotropin-releasing factor in the vasculature of pregnant rats. J Soc Gynecol Investig. 2000 ; 7 (3). 153-160.
19. Mackay KB, Stiefel TH, Ling N., Foster AC Effects of a selective agonist and antagonist of CRF2 receptors on cardiovascular function in the rat. Eur J Pharmacol. 2003 ; 469 (1-3). 111-115.
20. Coste SC, Kesterson RA, Heldwein KA, et al. Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin- releasing hormone receptor-2. Nat Genet. 2000 ; 24 (4). 403-409.
21. Gardiner SM, March JE, Kemp PA, Bennett T. A comparison between the cardiovascular actions of urocortin 1 and urocortin 2 (stresscopin-related peptide) in conscious rats. J Pharmacol Exp Ther. 2007 ; 321 (1). 221-226.
22. Chanalaris A., Lawrence KM, Stephanou A., et al. Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes. J Mol Cell Cardiol. 2003 ; 35 (10). 1295-1305.
23. Tao J., Zhang Y., Soong TW, Li S. Urocortin II inhibits the apoptosis of mesenteric arterial smooth muscle cells via L-type calcium channels in spontaneously hypertensive rats. Cell Physiol Biochem. 2006 ; 17 (3-4). 111-120.
24. Takahashi K., Totsune K., Murakami O., et al. Expression of urocortin III/stresscopin in human heart and kidney. J Clin Endocrinol Metab. 2004 ; 89 (4). 1897-1903.
25. Florio P., Franchini A., Reis FM, Pezzani I., Ottaviani E., Petraglia F. Human placenta, chorion, amnion and decidua express different variants of corticotropin-releasing factor receptor messenger RNA. Placenta. 2000 ; 21 (1). 32-37.
26. Murphy DJ, Stirrat GM Mortality and morbidity associated with early-onset preeclampsia. Hypertens Pregnancy. 2000 ; 19 (2). 221-231.
27. von Dadelszen P., Magee LA, Roberts JM Subclassification of preeclampsia. Hypertens Pregnancy. 2003 ; 22 (2). 143-148.
28. ACOG Committee on Practice Bulletin-Obstetric. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. Obstet Gynecol. 2002 ; 99 (1). 159-167.
29. Kliman HJ, Nestler JE, Sermasi E., Sanger JM, Strauss III JF Purification, characterization and in vitro differentiation of cytotrophoblasts from human term placenta. Endocrinology. 1986 ; 118 (4). 1567-1582.
30. Sun K., Yang K., Challis JRG. Differential regulation of 11 beta-hydroxysteroid dehydrogenase type 1 and 2 by nitric oxide in cultured human placental trophoblast and chorionic cell preparation. Endocrinology. 1997 ; 138 (11). 4912-4920.
31. Jaakkola P., Mole DR, Tian YM, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science. 2001 ; 292 (5516). 468-472.
32. Ietta F., Wu Y., Winter J., et al. Dynamic HIF-1alpha regulation during human placental development. Biol Reprod. 2006 ; 75 (1). 112-121.
33. Hung TH, Skepper JN, Charnock-Jones DS, Burton GJ Hypoxiareoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia. Circ Res. 2002 ; 90 (12). 1274-1281.
34. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001 ; 25 (4). 402-408.
35. Ietta F., Wu Y., Romagnoli R., et al. Oxygen regulation of macrophage migration inhibitory factor in human placenta. Am J Physiol Endocrinol Metab. 2007 ; 292 (1). E272 - E280.
36. Banerjee S., Smallwood A., Moorhead J., et al. Placental expression of interferon-gamma (IFN-gamma) and its receptor IFN-gamma R2 fail to switch from early hypoxic to late normotensive development in preeclampsia. Clin Endocrinol Metab. 2005 ; 90 (2). 944-952.
37. Benyo DF, Smarason A., Redman CW, Sims C., Conrad KP Expression of inflammatory cytokines in placentas from women with preeclampsia. Clin Endocrinol Metab. 2001 ; 86 (6). 2505-2512.
38. Munaut C., Lorquet S., Pequeux C., et al. Hypoxia is responsible for soluble vascular endothelial growth factor receptor-1 (VEGFR-1) but not for soluble endoglin induction in villous trophoblast. Hum Reprod. 2008 ; 23 (6). 1407-1415.
39. Nevo O., Soleymanlou N., Wu Y., et al. Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1. Am J Physiol Regul Integr Comp Physiol. 2006 ; 291 (4). R1085 - R1093.