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Volumn 40, Issue 5, 2010, Pages 404-410

Immuno- and gene-therapeutic strategies targeted against cancer (mainly focusing on pancreatic cancer)

Author keywords

Gastrointestinal cancer; Immunotherapy

Indexed keywords

ADENOVIRUS VECTOR; BISPECIFIC ANTIBODY; BLINATUMOMAB; CARCINOEMBRYONIC ANTIGEN; CYCLOPHOSPHAMIDE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DENILEUKIN DIFTITOX; E1B PROTEIN; GANCICLOVIR; GEMCITABINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR VACCINE; IMIQUIMOD; INTERLEUKIN 2; IPILIMUMAB; K RAS PROTEIN; MUCIN 1; NY ESO 1 ANTIGEN; PREPROENDOTHELIN 1; PROTEIN P53; THYMIDINE KINASE; TUMOR CELL VACCINE; UNCLASSIFIED DRUG;

EID: 77955667955     PISSN: 09411291     EISSN: 14362813     Source Type: Journal    
DOI: 10.1007/s00595-009-4120-8     Document Type: Review
Times cited : (2)

References (51)
  • 3
    • 0027370407 scopus 로고
    • Prognostic indicators for survival after resection of pancreatic adenocarcinoma
    • discussion 72-3
    • Geer RJ, Brennan MF. Prognostic indicators for survival after resection of pancreatic adenocarcinoma. Am J Surg 1993;165:68- 72; discussion 72-3.
    • (1993) Am J Surg , vol.165 , pp. 68-72
    • Geer, R.J.1    Brennan, M.F.2
  • 4
    • 0029991497 scopus 로고    scopus 로고
    • Long-term survival after curative resection for pancreatic ductal adenocarcinoma Clinicopathologic analysis of 5-year survivors
    • Conlon KC, Klimstra DS, Brennan MF. Long-term survival after curative resection for pancreatic ductal adenocarcinoma. Clinicopathologic analysis of 5-year survivors. Ann Surg 1996; 223:273-9.
    • (1996) Ann Surg , vol.223 , pp. 273-9
    • Conlon, K.C.1    Klimstra, D.S.2    Brennan, M.F.3
  • 5
    • 0032766272 scopus 로고    scopus 로고
    • Improving results of pancreaticoduodenectomy for pancreatic cancer
    • Yeo CJ, Cameron JL. Improving results of pancreaticoduodenectomy for pancreatic cancer. World J Surg 1999;23:907-12.
    • (1999) World J Surg , vol.23 , pp. 907-12
    • Yeo, C.J.1    Cameron, J.L.2
  • 6
    • 0031426723 scopus 로고    scopus 로고
    • Pancreaticoduodenectomy for pancreatic adenocarcinoma: Postoperative adjuvant chemoradiation improves survival. A prospective, single-institution experience
    • discussion 633-6
    • Yeo CJ, Abrams RA, Grochow LB, Sohn TA, Ord SE, Hruban RH, et al. Pancreaticoduodenectomy for pancreatic adenocarcinoma: postoperative adjuvant chemoradiation improves survival. A prospective, single-institution experience. Ann Surg 1997;225: 621-33; discussion 633-6.
    • (1997) Ann Surg , vol.225 , pp. 621-33
    • Yeo, C.J.1    Abrams, R.A.2    Grochow, L.B.3    Sohn, T.A.4    Ord, S.E.5    Hruban, R.H.6
  • 7
    • 0021867923 scopus 로고
    • Pancreatic cancer adjuvant combined radiation and chemotherapy following curative resection
    • Kalser MH, Ellenberg SS. Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection. Arch Surg 1985;120:899-903.
    • (1985) Arch Surg , vol.120 , pp. 899-903
    • Kalser, M.H.1    Ellenberg, S.S.2
  • 8
    • 0023262033 scopus 로고
    • Further evidence of effective adjuvant combined radiation and chemotherapy following curative resection of pancreatic cancer
    • Gastrointestinal Tumor Study Group
    • Gastrointestinal Tumor Study Group. Further evidence of effective adjuvant combined radiation and chemotherapy following curative resection of pancreatic cancer. Cancer 1987;59:2006-10.
    • (1987) Cancer , vol.59 , pp. 2006-10
  • 9
    • 0031183875 scopus 로고    scopus 로고
    • Gene therapy vector: Adenovirus vector (in Japanese)
    • Saito I. Gene therapy vector: adenovirus vector (in Japanese). Tanpakushitsu Kakusan Koso 1997;42:1798-805.
    • (1997) Tanpakushitsu Kakusan Koso , vol.42 , pp. 1798-805
    • Saito, I.1
  • 10
    • 0028237365 scopus 로고
    • Adenovirus-mediated in vivo gene transfer
    • discussion 101-3
    • Brody SL, Crystal RG. Adenovirus-mediated in vivo gene transfer. Ann NY Acad Sci 1994;716:90-101; discussion 101-3.
    • (1994) Ann NY Acad Sci , vol.716 , pp. 90-101
    • Brody, S.L.1    Crystal, R.G.2
  • 11
    • 0033060416 scopus 로고    scopus 로고
    • In vivo and ex vivo gene therapy strategies to treat tumors using adenovirus gene transfer vectors
    • Crystal RG. In vivo and ex vivo gene therapy strategies to treat tumors using adenovirus gene transfer vectors. Cancer Chemother Pharmacol 1999;43:suppl:S90-9.
    • (1999) Cancer Chemother Pharmacol , vol.43 , Issue.SUPPL.
    • Crystal, R.G.1
  • 12
    • 0035342191 scopus 로고    scopus 로고
    • Cancer gene therapy by adenovirusmediated gene transfer
    • Wu Q, Moyana T, Xiang J. Cancer gene therapy by adenovirusmediated gene transfer. Curr Gene Ther 2001;1:101-22.
    • (2001) Curr Gene Ther , vol.1 , pp. 101-22
    • Wu, Q.1    Moyana, T.2    Xiang, J.3
  • 15
    • 0034168678 scopus 로고    scopus 로고
    • Prospects for herpes-simplex-virus thymidine-kinase and cytokine gene transduction as immunomodulatory gene therapy for prostate cancer
    • Hassan W, Sanford MA, Woo SL, Chen SH, Hall SJ. Prospects for herpes-simplex-virus thymidine-kinase and cytokine gene transduction as immunomodulatory gene therapy for prostate cancer. World J Urol 2000;18:130-5.
    • (2000) World J Urol , vol.18 , pp. 130-5
    • Hassan, W.1    Sanford, M.A.2    Woo, S.L.3    Chen, S.H.4    Hall, S.J.5
  • 16
    • 0034095809 scopus 로고    scopus 로고
    • Suicide gene therapy for urogenital cancer: Current outcome and prospects
    • Nasu Y, Kusaka N, Saika T, Tsushima T, Kumon H. Suicide gene therapy for urogenital cancer: current outcome and prospects. Mol Urol 2000;4:67-71. (Pubitemid 30413642)
    • (2000) Molecular Urology , vol.4 , Issue.2 , pp. 67-71
    • Nasu, Y.1    Kusaka, N.2    Saika, T.3    Tsushima, T.4    Kumon, H.5
  • 18
    • 0027787053 scopus 로고
    • In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV tk retroviral gene therapy
    • Bi WL, Parysek LM, Warnick R, Stambrook PJ. In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV tk retroviral gene therapy. Hum Gene Ther 1993;4:725-31.
    • (1993) Hum Gene Ther , vol.4 , pp. 725-31
    • Bi, W.L.1    Parysek, L.M.2    Warnick, R.3    Stambrook, P.J.4
  • 19
  • 20
    • 0032037139 scopus 로고    scopus 로고
    • Gene therapy for malignant mesothelioma: A novel approach for an incurable cancer with increased incidence in Louisiana
    • Schwarzenberger P, Harrison L, Weinacker A, Gaumer R, Theodossiou C, Summer W, et al. Gene therapy for malignant mesothelioma: a novel approach for an incurable cancer with increased incidence in Louisiana. J LA State Med Soc 1998; 150:168-74.
    • (1998) J LA State Med Soc , vol.150 , pp. 168-74
    • Schwarzenberger, P.1    Harrison, L.2    Weinacker, A.3    Gaumer, R.4    Theodossiou, C.5    Summer, W.6
  • 21
    • 0031424456 scopus 로고    scopus 로고
    • Pancreatic carcinoma cell killing via adenoviral mediated delivery of the herpes simplex virus thymidine kinase gene
    • discussion 618-20
    • Rosenfeld ME, Vickers SM, Raben D, Wang M, Sampson L, Feng M, et al. Pancreatic carcinoma cell killing via adenoviral mediated delivery of the herpes simplex virus thymidine kinase gene. Ann Surg 1997;225:609-18; discussion 618-20.
    • (1997) Ann Surg , vol.225 , pp. 609-18
    • Rosenfeld, M.E.1    Vickers, S.M.2    Raben, D.3    Wang, M.4    Sampson, L.5    Feng, M.6
  • 22
    • 0030757856 scopus 로고    scopus 로고
    • Gene therapy for peritoneal dissemination of pancreatic cancer by liposome-mediated transfer of herpes simplex virus thymidine kinase gene
    • Aoki K, Yoshida T, Matsumoto N, Ide H, Hosokawa K, Sugimura T, et al. Gene therapy for peritoneal dissemination of pancreatic cancer by liposome-mediated transfer of herpes simplex virus thymidine kinase gene. Hum Gene Ther 1997;8: 1105-13.
    • (1997) Hum Gene Ther , vol.8 , pp. 1105-13
    • Aoki, K.1    Yoshida, T.2    Matsumoto, N.3    Ide, H.4    Hosokawa, K.5    Sugimura, T.6
  • 23
    • 0027548077 scopus 로고
    • Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir
    • Oldfield EH, Ram Z, Culver KW, Blaese RM, DeVroom HL, Anderson WF, et al. Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir. Hum Gene Ther 1993; 4:39-69.
    • (1993) Hum Gene Ther , vol.4 , pp. 39-69
    • Oldfield, E.H.1    Ram, Z.2    Culver, K.W.3    Blaese, R.M.4    DeVroom, H.L.5    Anderson, W.F.6
  • 24
    • 0029340302 scopus 로고
    • Gene therapy using adenovirus carrying the herpes simplex-thymidine kinase gene to treat in vivo models of human malignant mesothelioma and lung cancer
    • Hwang HC, Smythe WR, Elshami AA, Kucharczuk JC, Amin KM, Williams JP, et al. Gene therapy using adenovirus carrying the herpes simplex-thymidine kinase gene to treat in vivo models of human malignant mesothelioma and lung cancer. American J Respir Cell Mol Biol 1995;13:7-16.
    • (1995) American J Respir Cell Mol Biol , vol.13 , pp. 7-16
    • Hwang, H.C.1    Smythe, W.R.2    Elshami, A.A.3    Kucharczuk, J.C.4    Amin, K.M.5    Williams, J.P.6
  • 25
    • 0035553610 scopus 로고    scopus 로고
    • Antisense oligonucleotides specifi c to mutated K-ras genes inhibit invasiveness of human pancreatic cancer cell lines
    • Nakada Y, Saito S, Ohzawa K, Morioka CY, Kita K, Minemura M, et al. Antisense oligonucleotides specifi c to mutated K-ras genes inhibit invasiveness of human pancreatic cancer cell lines. Pancreatology 2001;1:314-9.
    • (2001) Pancreatology , vol.1 , pp. 314-9
    • Nakada, Y.1    Saito, S.2    Ohzawa, K.3    Morioka, C.Y.4    Kita, K.5    Minemura, M.6
  • 26
    • 0034967677 scopus 로고    scopus 로고
    • Oligonucleotide treatment of ras-induced tumors in nude mice
    • Wickstrom E. Oligonucleotide treatment of ras-induced tumors in nude mice. Mol Biotechnol 2001;18:35-55.
    • (2001) Mol Biotechnol , vol.18 , pp. 35-55
    • Wickstrom, E.1
  • 27
    • 0033624988 scopus 로고    scopus 로고
    • Adenovirus-mediated anti-K-ras ribozyme induces apoptosis and growth suppression of human pancreatic carcinoma
    • Tsuchida T, Kijima H, Hori S, Oshika Y, Tokunaga T, Kawai K, et al. Adenovirus-mediated anti-K-ras ribozyme induces apoptosis and growth suppression of human pancreatic carcinoma. Cancer Gene Ther 2000;7:373-83.
    • (2000) Cancer Gene Ther , vol.7 , pp. 373-83
    • Tsuchida, T.1    Kijima, H.2    Hori, S.3    Oshika, Y.4    Tokunaga, T.5    Kawai, K.6
  • 29
    • 0344188096 scopus 로고    scopus 로고
    • An adenovirus mutant that replicates selectively in p53- defi cient human tumor cells
    • Bischoff JR, Kirn DH, Williams A, Heise C, Horn S, Muna M, et al. An adenovirus mutant that replicates selectively in p53- defi cient human tumor cells. Science 1996;274:373-6.
    • (1996) Science , vol.274 , pp. 373-6
    • Bischoff, J.R.1    Kirn, D.H.2    Williams, A.3    Heise, C.4    Horn, S.5    Muna, M.6
  • 30
    • 0030917202 scopus 로고    scopus 로고
    • ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specifi c cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents
    • Heise C, Sampson-Johannes A, Williamu A, McCormick F, Von Hoff DD, Kirn DH. ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specifi c cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nat Med 1997;3:639-45.
    • (1997) Nat Med , vol.3 , pp. 639-45
    • Heise, C.1    Sampson-Johannes, A.2    Williamu, A.3    McCormick, F.4    Von Hoff, D.D.5    Kirn, D.H.6
  • 31
    • 0035076823 scopus 로고    scopus 로고
    • Safety and feasibility of injection with an E1B-55 kDa gene-deleted, replication-selective adenovirus (ONYX-015) into primary carcinomas of the pancreas: A phase I trial
    • Mulvihill S, Warren R, Venook A, Adler A, Randlev B, Heise C, et al. Safety and feasibility of injection with an E1B-55 kDa gene-deleted, replication-selective adenovirus (ONYX-015) into primary carcinomas of the pancreas: a phase I trial. Gene Ther 2001;8:308-15.
    • (2001) Gene Ther , vol.8 , pp. 308-15
    • Mulvihill, S.1    Warren, R.2    Venook, A.3    Adler, A.4    Randlev, B.5    Heise, C.6
  • 34
    • 0027538181 scopus 로고
    • Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specifi c, and long-lasting anti-tumor immunity
    • Dranoff G, Jaffee E, Lazenby A, Golumbek P, Levitsky H, Brose K, et al. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specifi c, and long-lasting anti-tumor immunity. Proc Natl Acad Sci USA 1993;90:3539-43.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 3539-43
    • Dranoff, G.1    Jaffee, E.2    Lazenby, A.3    Golumbek, P.4    Levitsky, H.5    Brose, K.6
  • 35
    • 0029783148 scopus 로고    scopus 로고
    • Protective antitumor immunity induced by immunization with completely allogeneic tumor cells
    • Toes RE, Bloom RJ, van der Voort E, Offringa R, Melief CJ, Kast WM. Protective antitumor immunity induced by immunization with completely allogeneic tumor cells. Cancer Res 1996; 56:3782-7.
    • (1996) Cancer Res , vol.56 , pp. 3782-7
    • Toes, R.E.1    Bloom, R.J.2    Van Der Voort, E.3    Offringa, R.4    Melief, C.J.5    Kast, W.M.6
  • 36
    • 0032503016 scopus 로고    scopus 로고
    • Enhanced tumor protection by granulocyte-macrophage colony-stimulating factor expression at the site of an allogeneic vaccine
    • Thomas MC, Greten TF, Pardoll DM, Jaffee EM. Enhanced tumor protection by granulocyte-macrophage colony-stimulating factor expression at the site of an allogeneic vaccine. Hum Gene Ther 1998;9:835-43.
    • (1998) Hum Gene Ther , vol.9 , pp. 835-43
    • Thomas, M.C.1    Greten, T.F.2    Pardoll, D.M.3    Jaffee, E.M.4
  • 37
    • 0031265017 scopus 로고    scopus 로고
    • Bioactivity of human GM-CSF gene therapy in metastatic renal cell carcinoma and prostate cancer
    • Simons JW. Bioactivity of human GM-CSF gene therapy in metastatic renal cell carcinoma and prostate cancer. Hinyokika Kiyo 1997;43:821-2.
    • (1997) Hinyokika Kiyo , vol.43 , pp. 821-2
    • Simons, J.W.1
  • 38
    • 0032573225 scopus 로고    scopus 로고
    • Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colonystimulating factor generates potent antitumor immunity in patients with metastatic melanoma
    • Soiffer R, Lynch T, Mihm M, Jung K, Rhuda C, Schmallinger JC, et al. Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colonystimulating factor generates potent antitumor immunity in patients with metastatic melanoma. Proc Natl Acad Sci USA 1998;95:13141-6.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13141-6
    • Soiffer, R.1    Lynch, T.2    Mihm, M.3    Jung, K.4    Rhuda, C.5    Schmallinger, J.C.6
  • 39
    • 0032741439 scopus 로고    scopus 로고
    • Induction of immunity to prostate cancer antigens: Results of a clinical trial of vaccination with irradiated autologous prostate tumor cells engineered to secrete granulocytemacrophage colony-stimulating factor using ex vivo gene transfer
    • Simons JW, Mikhak B, Chang JF, DeMarzo AM, Carducci MA, Lim M, et al. Induction of immunity to prostate cancer antigens: results of a clinical trial of vaccination with irradiated autologous prostate tumor cells engineered to secrete granulocytemacrophage colony-stimulating factor using ex vivo gene transfer. Cancer Res 1999;59:5160-8.
    • (1999) Cancer Res , vol.59 , pp. 5160-8
    • Simons, J.W.1    Mikhak, B.2    Chang, J.F.3    DeMarzo, A.M.4    Carducci, M.A.5    Lim, M.6
  • 40
    • 0031861172 scopus 로고    scopus 로고
    • Development and characterization of a cytokine-secreting pancreatic adenocarcinoma vaccine from primary tumors for use in clinical trials
    • Jaffee EM, Schtte M, Gossett J, Morsberger LA, Adler AJ, Thomas M, et al. Development and characterization of a cytokine-secreting pancreatic adenocarcinoma vaccine from primary tumors for use in clinical trials. The cancer journal from Sci Am 1998;4:194-203.
    • (1998) The cancer journal from Sci Am , vol.4 , pp. 194-203
    • Jaffee, E.M.1    Schtte, M.2    Gossett, J.3    Morsberger, L.A.4    Adler, A.J.5    Thomas, M.6
  • 41
    • 0035152718 scopus 로고    scopus 로고
    • Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: A phase I trial of safety and immune activation
    • Jaffee EM, Hruban RH, Biedrzycki B, Laheru D, Schepers K, Sauter PR, et al. Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activation. J Clin Oncol 2001;19:145-56.
    • (2001) J Clin Oncol , vol.19 , pp. 145-56
    • Jaffee, E.M.1    Hruban, R.H.2    Biedrzycki, B.3    Laheru, D.4    Schepers, K.5    Sauter, P.R.6
  • 42
    • 3543060047 scopus 로고    scopus 로고
    • Mesothelin-specifi c CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients
    • Thomas AM, Santarsiero LM, Lutz ER, Armstrong TD, Chen YC, Huang LQ, et al. Mesothelin-specifi c CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients. J Exp Med 2004;200:297-306.
    • (2004) J Exp Med , vol.200 , pp. 297-306
    • Thomas, A.M.1    Santarsiero, L.M.2    Lutz, E.R.3    Armstrong, T.D.4    Chen, Y.C.5    Huang, L.Q.6
  • 43
    • 40949157885 scopus 로고    scopus 로고
    • Allogeneic granulocyte macrophage colony-stimulating factorsecreting tumor immunotherapy alone or in sequence with cyclophosphamide for metastatic pancreatic cancer: A pilot study of safety, feasibility, and immune activation
    • Laheru D, Lutz E, Burke J, Biedrzycki B, Solt S, Onners B, et al. Allogeneic granulocyte macrophage colony-stimulating factorsecreting tumor immunotherapy alone or in sequence with cyclophosphamide for metastatic pancreatic cancer: a pilot study of safety, feasibility, and immune activation. Clin Cancer Res 2008; 14:1455-63.
    • (2008) Clin Cancer Res , vol.14 , pp. 1455-63
    • Laheru, D.1    Lutz, E.2    Burke, J.3    Biedrzycki, B.4    Solt, S.5    Onners, B.6
  • 44
    • 0036301503 scopus 로고    scopus 로고
    • CTLA-4: New insights into its biological function and use in tumor immunotherapy
    • Egen JG, Kuhns MS, Allison JP. CTLA-4: new insights into its biological function and use in tumor immunotherapy. Nat Immunol 2002;3:611-8.
    • (2002) Nat Immunol , vol.3 , pp. 611-8
    • Egen, J.G.1    Kuhns, M.S.2    Allison, J.P.3
  • 45
    • 34250223096 scopus 로고    scopus 로고
    • A pilot trial of CTLA-4 blockade with human anti-CTLA-4 in patients with hormone-refractory prostate cancer
    • Small EJ, Tchekmedyian NS, Rini BI, Fong L, Lowy I, Allison JP. A pilot trial of CTLA-4 blockade with human anti-CTLA-4 in patients with hormone-refractory prostate cancer. Clin Cancer Res 2007;13:1810-5.
    • (2007) Clin Cancer Res , vol.13 , pp. 1810-5
    • Small, E.J.1    Tchekmedyian, N.S.2    Rini, B.I.3    Fong, L.4    Lowy, I.5    Allison, J.P.6
  • 46
  • 47
    • 50949115267 scopus 로고    scopus 로고
    • Depletion of human regulatory T cells specifi - cally enhances antigen-specifi c immune responses to cancer vaccines
    • Morse MA, Hobeika AC, Osada T, Serra D, Niedzwiecki D, Lyerly HK, et al. Depletion of human regulatory T cells specifi - cally enhances antigen-specifi c immune responses to cancer vaccines. Blood 2008;112:610-8.
    • (2008) Blood , vol.112 , pp. 610-8
    • Morse, M.A.1    Hobeika, A.C.2    Osada, T.3    Serra, D.4    Niedzwiecki, D.5    Lyerly, H.K.6
  • 48
    • 40549097760 scopus 로고    scopus 로고
    • Adoptive immunotherapy for pancreatic cancer using MUC1 peptide-pulsed dendritic cells and activated T lymphocytes
    • Kondo H, Hazama S, Kawaoka T, Yoshino S, Yoshida S, Tokuno K, et al. Adoptive immunotherapy for pancreatic cancer using MUC1 peptide-pulsed dendritic cells and activated T lymphocytes. Anticancer Res 2008;28:379-87.
    • (2008) Anticancer Res , vol.28 , pp. 379-87
    • Kondo, H.1    Hazama, S.2    Kawaoka, T.3    Yoshino, S.4    Yoshida, S.5    Tokuno, K.6
  • 49
    • 44349117909 scopus 로고    scopus 로고
    • Adoptive cell therapy for patients with melanoma, using tumor-infi ltrating lymphocytes genetically engineered to secrete interleukin-2
    • Heemskerk B, Heemskerk B, Liu K, Dudley ME, Johnson LA, Kaiser A, et al. Adoptive cell therapy for patients with melanoma, using tumor-infi ltrating lymphocytes genetically engineered to secrete interleukin-2. Hum Gene Ther 2008; 19:496-510.
    • (2008) Hum Gene Ther , vol.19 , pp. 496-510
    • Heemskerk, B.1    Heemskerk, B.2    Liu, K.3    Dudley, M.E.4    Johnson, L.A.5    Kaiser, A.6
  • 50
    • 47949129948 scopus 로고    scopus 로고
    • Immunization of malignant melanoma patients with fulllength NY-ESO-1 protein using TLR7 agonist imiquimod as vaccine adjuvant
    • Adams S, O'Neill DW, Nonaka D, Hardin E, Chiriboga L, Siu K, et al. Immunization of malignant melanoma patients with fulllength NY-ESO-1 protein using TLR7 agonist imiquimod as vaccine adjuvant. J Immunol 2008;181:776-84.
    • (2008) J Immunol , vol.181 , pp. 776-84
    • Adams, S.1    O'Neill, D.W.2    Nonaka, D.3    Hardin, E.4    Chiriboga, L.5    Siu, K.6
  • 51
    • 49649120397 scopus 로고    scopus 로고
    • Tumor regression in cancer patients by very low doses of a T cell-engaging antibody
    • Bargou R, Leo E, Zugmaier G, Klinger M, Goebeler M, Knop S, et al. Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science 2008;321:974-7.
    • (2008) Science , vol.321 , pp. 974-7
    • Bargou, R.1    Leo, E.2    Zugmaier, G.3    Klinger, M.4    Goebeler, M.5    Knop, S.6


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