No evidence for intrathecal IgG synthesis to Epstein Barr virus nuclear antigen-1 in multiple sclerosis

Journal of Clinical Virology

Volumn 49, Issue 1, 2010, Pages 26-31

  Jafari, Naghmeh ^a   van Nierop, Gijsbert P ^a   Verjans, Georges M G M ^a   Osterhaus, Albert D M E ^a   Middeldorp, Jaap M ^b   Hintzen, Rogier Q ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

CSF; EBNA 1; Epstein Barr virus; Intrathecal synthesis; Multiple sclerosis

Indexed keywords

EPITOPE; EPSTEIN BARR VIRUS ANTIBODY; EPSTEIN BARR VIRUS ANTIGEN 1; IMMUNOGLOBULIN G; PEPTIDE; UNCLASSIFIED DRUG; VIRUS ANTIBODY;

ADULT; ANTIBODY SPECIFICITY; ARTICLE; B LYMPHOCYTE; BLOOD BRAIN BARRIER; CEREBROSPINAL FLUID; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOBLOTTING; IMMUNOGLOBULIN PRODUCTION; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; SERUM;

EID: 77955663639     PISSN: 13866532     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcv.2010.06.007     Document Type: Article

References (34)

1. Hauser S.L., Oksenberg J.R. The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration. Neuron 2006, 52:61-76.
2. Burgoon M.P., Cohrs R.J., Bennett J.L., Anderson S.W., Ritchie A.M., Cepok S., et al. Varicella zoster virus is not a disease-relevant antigen in multiple sclerosis. Ann Neurol 2009, 65:474-479.
3. Riverol M., Sepulcre J., Fernandez-Diez B., Villoslada P., Fernandez-Alonso M., Rubio M., et al. Antibodies against Epstein-Barr virus and herpesvirus type 6 are associated with the early phases of multiple sclerosis. J Neuroimmunol 2007, 192:184-185.
4. Sundström P., Juto P., Wadell G., Hallmans G., Svenningsson A., Nyström L., et al. An altered immune response to Epstein-Barr virus in multiple sclerosis: a prospective study. Neurology 2004, 62:2277-2282.
5. Lünemann J.D., Münz C. EBV in MS: guilty by association?. Trends Immunol 2009, 30:243-248.
6. Ramagopalan S.V., Valdar W., Dyment D.A., DeLuca G.C., Yee I.M., Giovannoni G., et al. Association of infectious mononucleosis with multiple sclerosis. A population-based study. Neuroepidemiology 2009, 32:257-262.
7. Levin L.I., Munger K.L., Rubertone M.V., Peck C.A., Lennette E.T., Spiegelman D., et al. Temporal relationship between elevation of Epstein-Barr virus antibody titers and initial onset of neurological symptoms in multiple sclerosis. JAMA 2005, 293:2496-2500.
8. Ascherio A., Munger K.L. Environmental risk factors for multiple sclerosis. Part I: the role of infection. Ann Neurol 2007, 61:288-299.
9. Farrell R.A., Antony D., Wall G.R., Clark D.A., Fisniku L., Swanton J., et al. Humoral immune response to EBV in multiple sclerosis is associated with disease activity on MRI. Neurology 2009, 73:32-38.
10. Cepok S., Zhou D., Srivastava R., Nessler S., Stei S., Bussow K., et al. Identification of Epstein-Barr virus proteins as putative targets of the immune response in multiple sclerosis. J Clin Invest 2005, 115:1352-1360.
11. Serafini B., Rosicarelli B., Franciotta D., Magliozzi R., Reynolds R., Cinque P., et al. Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain. J Exp Med 2007, 204:2899-2912.
12. Willis S.N., Stadelmann C., Rodig S.J., Caron T., Gattenloehner S., Mallozzi S.S., et al. Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain. Brain 2009, 132:3318-3328.
13. Peferoen L.A., Lamers F., Lodder L.N., Gerritsen W.H., Huitinga I., Melief J., et al. Epstein Barr virus is not a characteristic feature in the central nervous system in established multiple sclerosis. Brain 2010, 133:e137.
14. Rand K.H., Houck H., Denslow N.D., Heilman K.M. Epstein-Barr virus nuclear antigen-1 (EBNA-1) associated oligoclonal bands in patients with multiple sclerosis. J Neurol Sci 2000, 173:32-39.
15. Poser C.M. Revisions to the 2001 McDonald diagnostic criteria. Ann Neurol 2006, 59:727-728.
16. Fachiroh J., Paramita D.K., Hariwiyanto B., Harijadi A., Dahlia H.L., Indrasari S.R., et al. Single-assay combination of Epstein-Barr Virus (EBV) EBNA1- and viral capsid antigen-p18-derived synthetic peptides for measuring anti-EBV immunoglobulin G (IgG) and IgA antibody levels in sera from nasopharyngeal carcinoma patients: options for field screening. J Clin Microbiol 2006, 44:1459-1467.
17. Van Grunsven W.M., Spaan W.J., Middeldorp J.M. Localization and diagnostic application of immunodominant domains of the BFRF3-encoded Epstein-Barr virus capsid protein. J Infect Dis 1994, 170:13-19.
18. De Sanjosé S., Bosch R., Schouten T., Verkuijlen S., Nieters A., Foretova L., et al. Epstein-Barr virus infection and risk of lymphoma: immunoblot analysis of antibody responses against EBV-related proteins in a large series of lymphoma subjects and matched controls. Int J Cancer 2007, 121:1806-1812.
19. Greijer A.E., van de Crommert J.M., Stevens S.J., Middeldorp J.M. Molecular fine-specificity analysis of antibody responses to human cytomegalovirus and design of novel synthetic-peptide-based serodiagnostic assays. J Clin Microbiol 1999, 37:179-188.
20. Middeldorp J.M., Jongsma J., ter Haar A., Schirm J. The detection of immunoglobulin M and G antibodies against cytomegalovirus early and late antigens by enzyme-linked immunosorbent assay. J Clin Microbiol 1984, 20:763-771.
21. Middeldorp J.M., Meloen R.H. Epitope-mapping on the Epstein-Barr virus major capsid protein using systematic synthesis of overlapping oligopeptides. J Virol Methods 1988, 21:147-159.
22. Van Grunsven W.M., Nabbe A., Middeldorp J.M. Identification and molecular characterization of two diagnostically relevant marker proteins of the Epstein-Barr virus capsid antigen complex. J Med Virol 1993, 40:161-169.
23. Chen M.R., Middeldorp J.M., Hayward S.D. Separation of the complex DNA binding domain of EBNA-1 into DNA recognition and dimerization subdomains of novel structure. J Virol 1993, 67:4875-4885.
24. Hennard C., Pfuhl T., Buettner M., Becker K.F., Knöfel T., Middeldorp J., et al. The antibody 2B4 directed against the Epstein-Barr virus (EBV)-encoded nuclear antigen 1 (EBNA1) detects MAGE-4: implications for studies on the EBV association of human cancers. J Pathol 2006, 209:430-435.
25. Sundström P., Nyström M., Ruuth K., Lundgren E. Antibodies to specific EBNA-1 domains and HLA DRB11501 interact as risk factors for multiple sclerosis. J Neuroimmunol 2009, 215:102-107.
26. Lünemann J.D., Edwards N., Muraro P.A., Hayashi S., Cohen J.I., Munz C., et al. Increased frequency and broadened specificity of latent EBV nuclear antigen-1-specific T cells in multiple sclerosis. Brain 2006, 129:1493-1506.
27. Lang D., Vornhagen R., Rothe M., Hinderer W., Sonneborn H.H., Plachter B. Cross-reactivity of Epstein-Barr virus-specific immunoglobulin M antibodies with cytomegalovirus antigens containing glycine homopolymers. Clin Diagn Lab Immunol 2001, 8:747-756.
28. Fox R., Sportsman R., Rhodes G., Luka J., Pearson G., Vaughan J. Rheumatoid arthritis synovial membrane contains a 62,000-molecular-weight protein that shares an antigenic epitope with the Epstein-Barr virus-encoded associated nuclear antigen. J Clin Invest 1986, 77:1539-1547.
29. Hennard C., Pfuhl T., Buettner M., Becker K.F., Knöfel T., Middeldorp J., Kremmer E., Niedobitek G., Grässer F. The antibody 2B4 directed against the Epstein-Barr virus (EBV)-encoded nuclear antigen 1 (EBNA1) detects MAGE-4: implications for studies on the EBV association of human cancers. J Pathol 2006, 209:430-435.
30. Sargsyan S.A., Shearer A.J., Ritchie A.M., Burgoon M.P., Anderson S., Hemmer B., Stadelmann C., Gattenlöhner S., Owens G.P., Gilden D., Bennett J.L. Absence of Epstein-Barr virus in the brain and CSF of patients with multiple sclerosis. Neurology 2010, 74:1127-1135.
31. Kusunoki Y., Huang H., Fukuda Y., Ozaki K., Saito M., Hirai Y., et al. A positive correlation between the precursor frequency of cytotoxic lymphocytes to autologous Epstein-Barr virus-transformed B cells and antibody titer level against Epstein-Barr virus-associated nuclear antigen in healthy seropositive individuals. Microbiol Immunol 1993, 37:461-469.
32. + T-cell subsets mediate immune recognition of Epstein Barr virus nuclear antigen 1 in healthy virus carriers. Blood 2007, 109:1138-1146.
33. Lünemann J.D., Jelcić I., Roberts S., Lutterotti A., Tackenberg B., Martin R., et al. EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-gamma and IL-2. J Exp Med 2008, 205:1763-1773.
34. Leen A., Meij P., Redchenko I., Middeldorp J.M., Bloemena E., Rickinson A., et al. Differential immunogenicity of Epstein-Barr virus latent-cycle proteins for human CD4(+) T-helper 1 responses. J Virol 2001, 75:8649-8659.