Varicella zoster virus is not a disease-relevant antigen in multiple sclerosis

Annals of Neurology

Volumn 65, Issue 4, 2009, Pages 474-479

  Burgoon, Mark P ^a   Cohrs, Randall J ^a   Bennett, Jeffrey L ^a   Anderson, Sarah W ^a   Ritchie, Alanna M ^a   Cepok, Sabine ^b   Hemmer, Bernhard ^b   Gilden, Don ^a   Owens, Gregory P ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; RECOMBINANT ANTIBODY; VIRUS ANTIBODY; VIRUS ANTIGEN; VIRUS DNA;

ACUTE DISEASE; ADULT; AGED; ARTICLE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; ELECTRON MICROSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENOME; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PLASMA CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VARICELLA ZOSTER VIRUS; VIRION; CHILD; GENETICS; IMMUNOLOGY; ISOLATION AND PURIFICATION; METHODOLOGY; MIDDLE AGED; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE; VIROLOGY;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; CHILD; DNA, VIRAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HERPESVIRUS 3, HUMAN; HUMANS; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MIDDLE AGED; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; VIRION; YOUNG ADULT;

EID: 65649084831     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.21605     Document Type: Article

References (16)

1. Bennett JL, Yu X, Gilden DH, et al. Infectious agents and multiple sclerosis. In: Raine CS, McFarland HF, Hohlfeld R, eds. Multiple sclerosis: a comprehensive text. New York: Saunders Elsevier, 2008:226-236.
2. Sotelo J, Martinez-Palomo A, Ordonez G, et al. Varicella-zoster virus in cerebrospinal fluid at relapses of multiple sclerosis. Ann Neurol 2008;63:303-311.
3. Burgoon MP, Keays KM, Owens GP, et al. Laser-capture mi- crodissection of plasma cells from subacute sclerosing panen- cephalitis brain reveals intrathecal disease-relevant antibodies. Proc Natl Acad SciUSA 2005;102:7245-7250.
4. Owens GP, Ritchie AM, Gilden DH, et al. Measles virus- specific plasma cells are prominent in subacute sclerosing pan- encephalitis CSF. Neurology 2007;68:1815-1819.
5. Yu X, Gilden DH, Ritchie AM, et al. Specificity of recombi- nant antibodies generated from multiple sclerosis cerebrospinal fluid probed with a random peptide library. J Neuroimmunol 2006;172:121-131.
6. Cohrs RJ, Gilden DH. Prevalence and abundance of latently transcribed varicella-zoster virus genes in human ganglia. J Virol 2007;81:2950-2956.
7. Cohrs RJ, Randall J, Smith J, et al. Analysis of individual human trigeminal ganglia for latent herpes simplex virus type 1 and varicella-zoster virus nucleic acids using real-time PCR. J Virol 2000;74:11464-11471.
8. Gilden DH, Shtram Y, Friedmann A, et al. Extraction of cell- associated varicella-zoster virus DNA with Triton X-100-NaCl. J Virol Methods 1982;4:263-275.
9. Owens GP, Shearer AJ, Yu X, et al. Screening random peptide libraries with subacute sclerosing panencephalitis brain-derived recombinant antibodies identifies multiple epitopes in the C-terminal region of the measles virus nucleocapsid protein. J Virol 2006;80:12121-12130.
10. Burgoon MP, Williamson RA, Owens GP, et al. Cloning the antibody response in humans with inflammatory CNS disease: isolation of measles virus-specific antibodies from phage display libraries of a subacute sclerosing panencephalitis brain. J Neuroimmunol 1999;94:204-211.
11. Ordonez G, Pineda B, Garcia-Navarrete R, et al. Brief presence of varicella-zoster viral DNA in mononuclear cells during relapses of multiple sclerosis. Arch Neurol 2004;61: 529 -532.
12. Mancuso R, Delbue S, Borghi E, et al. Increased prevalence of varicella zoster virus DNA in cerebrospinal fluid from patients with multiple sclerosis. J Med Virol 2007;79:192-199.
13. Sotelo J, Ordonez G, Pineda B. Varicella-zoster virus at relapses of multiple sclerosis. J Neurol 2007;254:493-500.
14. Forghani B, Cremer NE, Johnson KP, et al. Comprehensive viral immunology of multiple sclerosis. III. Analysis of CSF antibodies by radioimmunoassay. Arch Neurol 1980;37:616-619.
15. Burgoon MP, Hammack BN, Owens GP, et al. Oligoclonal immunoglobulins in cerebrospinal fluid during varicella zoster virus (VZV) vasculopathy are directed against VZV. Ann Neurol 2003;54:459 -463.
16. Obermeier B, Mentele R, Malotka J, et al. Matching of the oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis. Nat Med 2008;14: 688 -693.