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Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 17, 2010, Pages 5241-5244

Hit-to-lead optimization of a series of carboxamides of ethyl 2-amino-4-phenylthiazole-5-carboxylates as novel adenosine A2A receptor antagonists

(7) Sams, Anette Graven a Mikkelsen, Gitte Kobberøe a Larsen, Mogens a Torup, Lars a Brennum, Lise Tøttrup a Schrøder, Tenna Juul a Bang Andersen, Benny a

a H LUNDBECK A S (Denmark)

Author keywords

A2A; Adenosine; Antagonist; Parkinson's Disease

Indexed keywords

ADENOSINE A2A RECEPTOR ANTAGONIST; AMIDE; CYCLOPROPANECARBOXYLIC ACID [5 (5 METHYL[1,2,4]OXADIAZOL 3 YL) 4 PHENYL THIAZOL 2 YL]AMIDE; HALOPERIDOL; ISTRADEFYLLINE; PRELADENANT; SCH 420814; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG BINDING; DRUG BLOOD LEVEL; DRUG STRUCTURE; DRUG SYNTHESIS; LOCOMOTION; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; PARKINSON DISEASE;

AMIDES; CARBOXYLIC ACIDS; PURINERGIC P1 RECEPTOR ANTAGONISTS; RECEPTOR, ADENOSINE A2A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955661042 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.06.138 Document Type: Article

Times cited : (14)

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