Lansoprazole, a proton pump inhibitor, reduces the severity of indomethacin-induced rat enteritis

International Journal of Molecular Medicine

Volumn 17, Issue 1, 2006, Pages 89-93

  Kuroda, Masaaki ^a   Yoshida, Norimasa ^a   Ichikawa, Hiroshi ^b   Takagi, Tomohisa ^c   Okuda, Toshimitsu ^a   Naito, Yuji ^c   Okanoue, Takeshi ^a   Yoshikawa, Toshikazu ^a,c  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY   (Japan)

^c KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Enteritis; Indomethacin; Lansoprazole; Proton pump inhibitor

Indexed keywords

2 [[(2 PYRIDYL)METHYL]SULFINYL]BENZIMIDAZOLE DERIVATIVE; ALPHA CHEMOKINE; CXCL1 PROTEIN, RAT; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT, RAT; CYTOKINE-INDUCED NEUTROPHIL CHEMOATTRACTANT, RAT; DRUG DERIVATIVE; INDOMETACIN; LANSOPRAZOLE; NONSTEROID ANTIINFLAMMATORY AGENT; OMEPRAZOLE; PEROXIDASE; PROTON PUMP; SIGNAL PEPTIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; DRUG EFFECT; ENTERITIS; GENETICS; HISTOLOGY; INTESTINE MUCOSA; MALE; METABOLISM; PATHOLOGY; RAT; SMALL INTESTINE; WISTAR RAT;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHEMOKINES, CXC; ENTERITIS; INDOMETHACIN; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTESTINAL MUCOSA; INTESTINE, SMALL; MALE; OMEPRAZOLE; PEROXIDASE; PROTON PUMPS; RATS; RATS, WISTAR; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 33644874756     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.17.1.89     Document Type: Article

References (31)

1. Kent TH, Cardelli RM and Stamler FW: Small intestinal ulcers and intestinal flora in rats given indomethacin. Am J Pathol 54: 237-249, 1969.
2. Robert A and Asano T: Resistance of germfree rats to indomethacin-induced intestinal lesions. Prostaglandins 14: 333-341, 1977. (Pubitemid 8171147)
3. Fang WF, Broughton A and Jacobson ED: Indomethacin-induced intestinal inflammation. Am J Dig Dis 22: 749-760, 1977.
4. Bjarnason I, Zanelli G, Smith T, et al: Non-steroidal anti-inflammatory drug-induced intestinal inflammation in humans. Gastroenterology 93: 480-489, 1987. (Pubitemid 17119242)
5. Whittle BJ: Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat. Gastroenterology 80: 94-98, 1981.
6. Weissenborn U, Maedge S, Buettner D and Sewing KF: Indomethacin-induced gastrointestinal lesions in relation to tissue concentration, food intake and bacterial invasion in the rat. Pharmacology 30: 32-39, 1985. (Pubitemid 15177152)
7. Redfern JS, Blair AJ III, Lee E and Feldman M: Gastrointestinal ulcer formation in rabbits immunized with prostaglandin E2. Gastroenterology 93: 744-752, 1987. (Pubitemid 17155999)
8. Yamada T, Deitch E, Specian RD, Perry MA, Sartor RB and Grisham MB: Mechanisms of acute and chronic intestinal inflammation induced by indomethacin. Inflammation 17: 641, 1993.
9. Whittle BJ, Laszlo F, Evans SM and Moncada S: Induction of nitric oxide synthase and microvascular injury in the rat jejunum provoked by indomethacin. Br J Pharmacol 116: 2286-2290, 1995.
10. Horn J: The proton-pump inhibitors: similarities and differences. Clin Ther 22: 266-280, 2000.
11. +)ATPase. Nature 290: 159-161, 1981.
12. Langtry HD and Wilde MI: Omeprazole. A review of its use in Helicobacter pylori infection, gastro-oesophageal reflux disease and peptic ulcers induced by non-steroidal anti-inflammatory drugs. Drugs 56: 447-486, 1998.
13. Garnett WR: Lansoprazole: a proton pump inhibitor. Ann Pharmacother 30: 1425-1436, 1996.
14. Zimmermann AE and Katona BG: Lansoprazole: a comprehensive review. Pharmacotherapy 17: 308-326, 1997.
15. Wolfe MM and Sachs G: Acid suppression: optimizing therapy for gastroduodenal ulcer healing, gastroesophageal reflux disease, and stress-related erosive syndrome. Gastroenterology 118 (suppl 1): S9-S31, 2000.
16. Wandall JH: Effects of omeprazole on neutrophil chemotaxis, super oxide production, degranulation, and translocation of cytochrome b-245. Gut 33: 617-621, 1992.
17. Yoshida N, Yoshikawa T, Tanaka Y, et al: A new mechanism for anti-inflammatory actions of proton pump inhibitors - inhibitory effects on neutrophil-endothelial cell interactions. Aliment Pharmacol Ther 14 (suppl 1): 74-81, 2000.
18. Ichikawa H, Yoshida N, Takagi T, et al: Lansoprazole ameliorates intestinal mucosal damage induced by ischemia-reperfusion in rats. World J Gastroenterol 10: 2814-2817, 2004. (Pubitemid 39302995)
19. Ohkawa H, Ohnishi N and Yagi K: Assay for lipid peroxides for animal tissues by thiobarbituric acid reaction. Anal Biochem 95: 351-358, 1979.
20. Grisham MB, Hernandez LA and Granger DN: Xanthine oxidase and neutrophil infiltration in intestinal ischemia. Am J Physiol 251: G567-G574, 1986.
21. Basivireddy J, Jacob M, Ramamoorthy P, Pulimood AB and Balasubramanian KA: Indomethacin-induced free radical-mediated changes in the intestinal brush border membranes. Biochem Pharmacol 65: 683-695, 2003.
22. Basivireddy J, Vasudevan A, Jacob M and Balasubramanian KA: Indomethacin-induced mitochondrial dysfunction and oxidative stress in villus enterocytes. Biochem Pharmacol 64: 339, 2002.
23. Davies NM and Jamali F: Pharmacological protection of NSAID-induced intestinal permeability in the rat: effect of tempo and metronidazole as potential free radical scavengers. Hum Exp Toxicol 16: 345-349, 1997.
24. Suzuki M, Mori M, Fukumura D, Suzuki H, Miura S and Ishii H: Omeprazole attenuates neutrophil-endothelial cell adhesive interaction induced by extracts of Helicobacter pylori. J Gastroenterol Hepatol 14: 27-31, 1999.
25. Ohara T and Arakawa T: Lansoprazole decreases peripheral blood monocytes and intercellular adhesion molecule-1-positive mononuclear cells. Dig Dis Sci 44: 1710-1715, 1999.
26. Suzuki M, Mori M, Miura S, Suematsu M, Fukumura D, Kimura H, et al: Omeprazole attenuates oxygen-derived free radical production from human neutrophils. Free Radic Biol Med 21: 727-731, 1996.
27. Biswas K, Bandyopadhyay U, Chattopadhyay I, Varadaraj A, Ali E and Banerjee RK: A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical. J Biol Chem 278: 10993-11001, 2003.
28. Zedtwitz-Liebenstein K, Wenisch C, Patruta S, Parschalk B, Daxbock F and Graninger W: Omeprazole treatment diminishes intra- and extracellular neutrophil reactive oxygen production and bactericidal activity. Crit Care Med 30: 1118-1122, 2002.
29. Noble DW: Proton pump inhibitors and stress ulcer prophylaxis: pause for thought? Crit Care Med 30: 1175-1176, 2002.
30. Tsuruma T, Yagihashi A, Tarumi K and Hirata K: Anti-rat IL-8 (CINC) monoclonal antibody administration reduces ischemia-reperfusion injury in small intestine. Transplant Proc 30: 2644-2645, 1998.
31. Yagihashi A, Tsuruma T, Tarumi K, Kameshima T, Yajima T, Yanai Y, et al: Prevention of small intestinal ischemia-reperfusion injury in rat by anti-cytokine-induced neutrophil chemoattractant monoclonal antibody. J Surg Res 78: 92-96, 1998.