Synthesis of a series of novel 2,4,5-trisubstituted selenazole compounds as potential PLTP inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 17, 2010, Pages 5123-5125

  Ling, Cui ^a   Zheng, Zhibing ^a   Jiang, Xian Cheng ^b   Zhong, Wu ^a   Li, Song ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^b STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

2,4,5 Trisubstituted selenazole; Atherosclerosis; PLTP inhibitor

Indexed keywords

2,4,5 SELENAZOLE; PHOSPHOLIPID TRANSFER PROTEIN; SELENAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; IN VITRO STUDY; PROTON NUCLEAR MAGNETIC RESONANCE;

AZOLES; DRUG EVALUATION, PRECLINICAL; INHIBITORY CONCENTRATION 50; PHOSPHOLIPID TRANSFER PROTEINS; SELENIUM COMPOUNDS;

EID: 77955654866     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.07.017     Document Type: Article

References (24)

1. J. Lie, M. Moerland, and T. van Gent Biochim. Biophys. Acta 1761 2006 1070
2. A.R. Tall, S. Krumholz, T. Olivecrona, and R.J. Deckelbaum J. Lipid Res. 26 1985 842
3. X.C. Jiang, S. Qin, and C. Qiao Nat. Med. 7 2001 847
4. R. Van Haperen, A. van Tol, and T. van Gent J. Biol. Chem. 277 2002 48938
5. X.P. Yang, D. Yan, and C. Qiao Arterioscler. Thromb. Vasc. Biol. 23 2003 1601
6. A. Van Tol, M. Jauhiainen, and R. de Crom Int. J. Tissue React. 22 2000 79
7. R. Vikstedt, D. Ye, and J. Metso Arterioscler. Thromb. Vasc. Biol. 27 2007 578
8. A. Schlitt, C. Bickel, and P. Thumma Arterioscler. Thromb. Vasc. Biol. 23 2003 1857
9. M. Vergeer, G.M. Dallinga-Thie, and R.P.F. Dullaart Future Lipidol. 3 2008 327
10. V. Maher, J. Sinfuego, P. Chao, and J. Parekh Drugs 54 1997 1
11. J. Kjekshus, and T.R. Pedersen Am. J. Cardiol. 76 1995 64C
12. G. Kleiger, L.J. Beamer, and R. Grothe J. Mol. Biol. 299 2000 1019
13. X. Qiu, A. Mistry, and M.J. Ammirati Nat. Struct. Mol. Biol. 14 2007 106
14. J. Huusk, G. Wohlfahrt, and M. Jauhiainen J. Lipid Res. 40 1999 1123
15. C. Bruce, L.J. Beamer, and A.R. Tall Curr. Opin. Struct. Biol. 7 1998 906
16. Jiang, X. C.; Tall, A. R. PCT WO 2002048650, 2002.
17. Carsten de, S.; Arndt de, B.; Michael, L. PCT WO 9834920, 1998.
18. E.J. Reinhard, J.L. Wang, and R.C. Durley J. Med. Chem. 46 2003 2152
19. Y. Xia, B. Mirzai, and S. Chackalamannil Bioorg. Med. Chem. Lett. 6 1996 919
20. S.J. Coval, M.A. Conover, and R. Mierzwa Bioorg. Med. Chem. Lett. 1995 5, 605
21. Li, S.; Guo, C. B.; Jiang, X. C., et al. PCT WO 2008006257, 2008.
22. M. Kodomari, T. Aoyama, and Y. Suzuki Tetrahedron Lett. 43 2002 1717
23. J.D. Pelletier, and D. Poirier Tetrahedron Lett. 35 1994 1051
24. +: m/z = 449.