A novel secretagogue increases cardiac contractility by enhancement of L-type Ca2+ current

Biochemical Pharmacology

Volumn 80, Issue 7, 2010, Pages 1000-1006

  Su, Zhi ^a   Widomski, Deborah L ^a   Liu, Xiaoqin ^a   Limberis, James T ^a   Green, Jonathon ^a   Diaz, Gilbert ^a   Martin, Ruth L ^a   Cox, Bryan F ^a   Gintant, Gary A ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Cardiac myocytes; Inotropy; L type Ca2+ current; N'1 (3,3,6,8 tetramethyl 1 oxo 1,2,3,4 tetrahydronaphthalen 2 yliden) 2 cyanoethanohydrazide; Rabbit

Indexed keywords

BETA ADRENERGIC RECEPTOR; CALCIUM CHANNEL L TYPE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; FRAGMENT 14,22 MYRISTOYLATED TRIFLUOROACETATE SALT; ISOPRENALINE; N' 1 ( 3,3,6,8 TETRAMETHYL 1 OXO 1,2,3,4 TETRAHYDRONAPHTHALEN 2 YLIDEN) 2 CYANOETHANOHYDRAZIDE; NAPHTHALENE DERIVATIVE; PROPRANOLOL; TTYC; UNCLASSIFIED DRUG; CALCIUM; GLUCAGON LIKE PEPTIDE 1;

AMPLITUDE MODULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; HEART; HEART CONDUCTION; HEART LEFT VENTRICLE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBER MEMBRANE STEADY POTENTIAL; HEART VENTRICLE; IN VITRO STUDY; IN VIVO STUDY; INOTROPISM; MALE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; SARCOMERE LENGTH; VOLTAGE CLAMP; WHOLE CELL; ANIMAL; CYTOLOGY; DRUG EFFECTS; HEART CONTRACTION; HEART MUSCLE CELL; METABOLISM; PATCH CLAMP TECHNIQUE; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; CALCIUM; GLUCAGON-LIKE PEPTIDE 1; HEART; MALE; MUSCLE CELLS; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; RABBITS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77955653586     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.06.006     Document Type: Article

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