E-cadherin promoter hypermethylation may contribute to protein inactivation in pterygia

Molecular Vision

Volumn 16, Issue , 2010, Pages 1047-1053

  Young, Chi Hsien ^a,b   Chiu, Yu Te ^c,d   Shih, Tung Sheng ^b,d   Lin, Wan Ru ^b   Chiang, Chun Chi ^c   Chou, Ying Erh ^a   Cheng, Ya Wen ^a   Tsai, Yi Yu ^c  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b Institute of Occupational Safety and Health   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; UVOMORULIN;

ADULT; AGED; ARTICLE; CELL PROLIFERATION; CONJUNCTIVA EPITHELIUM; CONTROLLED STUDY; DISEASE COURSE; DNA METHYLATION; FEMALE; GENE MUTATION; GENETIC EPIGENESIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PTERYGIUM; SIGNAL TRANSDUCTION;

AGED; BETA CATENIN; CADHERINS; DNA METHYLATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PROMOTER REGIONS, GENETIC; PTERYGIUM; STAINING AND LABELING; TISSUE DISTRIBUTION;

EID: 77955634112     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Tan DT, Lim AS, Goh HS, Smith DR. Abnormal expression of the p53 tumor suppressor gene in the conjunctiva of patients with pterygium. Am J Ophthalmol 1997; 123:404-5.
2. Dushku N, Reid TW. P53 expression in altered limbal basal cells of pingula, pterygia, and limbal tumors. Curr Eye Res 1997; 16:1179-92.
3. Onur C, Orhan D, Orhan M, Dizbay Sak S, Tulunay O, Irkeç M. Expression of p53 protein in pterygia. Eur J Ophthalmol 1998; 8:157-61.
4. Livni N, Ilsar M, Frucht-Pery J, Chowers I, Pe'er J, Zamir E. Proliferative activity and p53 expression in primary and recurrent pterygia. Ophthalmology 2001; 108:985-8.
5. Weinstein O, Rosenthal G, Zirkin H, Monos T, Lifshitz T, Argov S. Overexpression of p53 tumor suppressor gene in pterygia. Eye 2002; 16:619-21.
6. Goh HS, Smith DR, Tan DT, Tang WY, Liu YP. Apoptosis and apoptosis related gene expression in normal conjunctiva and pterygium. Br J Ophthalmol 2000; 84:212-6.
7. Dushku N, Hatcher SLS, Albert DM. P53 expression and relation to human papillomavirus infection in pinguecula, pterygia, and limbal tumors. Arch Ophthalmol 1999; 117:1593-9.
8. Jankowski JA, Bedford FK, Kim YS. Changes in gene structure and regulation of E-cadherin during epithelial development, differentiation, and disease. Prog Nucleic Acid Res Mol Biol 1997; 57:187-215.
9. van Roy F, Berx G. The cell-cell adhesion molecule E-cadherin. Cell Mol Life Sci 2008; 65:3756-88.
10. Tucker EL, Pignatelli M. Catenins and their associated proteins in colorectal cancer. Histol Histopathol 2000; 15:251-60.
11. Cox RT, Kirkpatrick C, Peifer M. Armadillo is required for adherens junction assembly, cell polarity, and morphogenesis during Drosophila embryogenesis. J Cell Biol 1996; 134:133-48.
12. Kelly GM, Erezyilmaz DF, Moon RT. Induction of a secondary embryonic axis in zebrafish occurs following the overexpression of beta-catenin. Mech Dev 1995; 53:261-73.
13. Kikuchi A, Kishida S, Yamamoto H, Ikeda S, Kishida M, Sakamoto I, Koyama S. Axin, a negative regulator of the Wnt signaling pathway,directily interacts with adnomatous polyposis coli and regulates the stabilization of beta-catenin. J Biol Chem 1998; 273:10823-6.
14. Yamamoto H, Kishida S, Kishida M, Ikeda S, Takada S, Kikuci A. Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3 beta regulates its atbility. J Biol Chem 1999; 274:10681-4.
15. Kinzler KW, Vogelstein B, Clevers H, Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science 1997; 275:1784-7.
16. Behrens J, von Kries JP, Kuhl M, Bruhn L, Wedlich D, Grosschedl R, Birchmeier W. Functional interaction of betacatenin with the transcription factor LEF-1. Nature 1996; 382:638-42.
17. Polakis P. Wnt signaling and cancer. Genes Dev 2000; 14:1837-51.
18. Wong NACS, Pignatelli M. Catenin-a linchpin in colorectal carcinogenesis? Am J Pathol 2002; 160:389-401.
19. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B, Kinzler KW. Identification of c- MYC as a target of the APC pathway. Science 1998; 281:1509-12.
20. Shtutman M, Zhurinsky J, Simcha I, Albanese C, D'Amico M, Pestell R, Ben-Ze'ev A. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc Natl Acad Sci USA 1999; 96:5522-7. PMID: 10318916
21. Fearon E. Tumor suppressor genes. In: Vogelstein B, Kinzler KW, editors. The Genetic Basis of Human Cancer. New York: McGraw-Hill Health Professions Division; 1998. p. 229-240.
22. Esteller M. CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future. Oncogene 2002; 21:5427-40.
23. Chen PL, Cheng YW, Chiang CC, Tseng SH, Chau PS, Tsai YY. Hypermethylation of the p16 gene promoter in pterygia and its association with the expression of DNA methyltransferase 3b. Mol Vis 2006; 12:1411-6.
24. Shimmura S, Ishioka M, Hanada K, Shimazaki J, Tsubota K. Telomerase Activity and p53 Expression in Pterygia. Invest Ophthalmol Vis Sci 2000; 41:1364-9.
25. Kase S, Takahashi S, Sato I, Nakanishi K, Yoshida K. S. Expression of p27(KIP1) and cyclin D1, and cell proliferation in human pterygium. Br J Ophthalmol 2007; 91:958-61. Ohno
26. Fagotto F, Gumbiner BM. Cell contact-dependent signaling. Dev Biol 1996; 180:445-54.
27. Perrais M, Chen X, Perez-Moreno M, Barry M. E-Cadherin homophilic ligation inhibits cell growth and epidermal growth factor receptor signaling independently of other cell interactions. Molecular Biology of the Cell 2007; 18:2013-25.
28. Ng TL, Gown AM, Barry TS, Cheang MC, Chan AK, Turbin DA, Hsu FD, West RB, Nielsen TO. Nuclear beta-catenin in mesenchymal tumors. Mod Pathol 2005; 18:68-74.
29. Tetsu O, McCormick F. β-Catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999; 398:422-6.
30. Ishida K, Ito S, Wada N, Deguchi H, Hosoda M, Nohno T. Nuclear localization of beta-catenin involved in precancerous change in oral leukoplakia. Mol Cancer 2007; 6:62.
31. Kase S, Osaki M, Sato I, Takahashi S, Nakanishi K, Yoshida K, Ito H, Ohno S. Immunolocalisation of E-cadherin and - catenin in human pterygium. Br J Ophthalmol 2007; 91:1209-12.
32. Fearon E. Tumor suppressor genes. In: Vogelstein B, Kinzler KW, editors. The Genetic Basis of Human Cancer. New York: McGraw-Hill Health Professions Division; 1998. p. 229-240.
33. Bestor TH. The DNA methyltransferases of mammals. Hum Mol Genet 2000; 9:2395-402.
34. Robertson KD. DNA methylation, methyltransferases, and cancer. Oncogene 2001; 20:3139-55.
35. Chen PL, Cheng YW, Chiang CC, Tseng SH, Chau PS, Tsai YY. Hypermethylation of the p16 gene promoter in pterygia and its association with the expression of DNA methyltransferase 3b. Mol Vis 2006; 12:1411-6.
36. Herfs M, Hubert P, Kholod N, Caberg JH, Gilles C, Berx G, Savagner P, Boniver J, Delvenne P. Transforming growth factor-beta1-mediated Slug and Snail transcription factor upregulation reduces the density of Langerhans cells in epithelial metaplasia by affecting E-cadherin expression. Am J Pathol 2008; 172:1391-402.
37. Kato N, Shimmura S, Kawakita T, Miyashita H, Ogawa Y, Yoshida S, Higa K, Okano H, Tsubota K. Beta-catenin activation and epithelial-mesenchymal transition in the pathogenesis of pterygium. Invest Ophthalmol Vis Sci 2007; 48:1511-7.
38. Liu Y, Hong Y, Zhao Y, Ismail TM, Wong Y, Eu KW. Histone H3 (lys-9) deacetylation is associated with transcriptional silencing of E-cadherin in colorectal cancer cell lines. Cancer Invest 2008; 26:575-82.
39. Hayashi A, Horiuchi A, Kikuchi N, Hayashi T, Fuseya C, Suzuki A, Konishi I, Shiozawa T. Type-specific roles of histone deacetylase (HDAC) overexpression in ovarian carcinoma: HDAC1 enhances cell proliferation and HDAC3 stimulates cell migration with downregulation of E-cadherin. Int J Cancer. 2010