p53 expression and relation to human papillomavirus infection in pingueculae, pterygia, and limbal tumors

Archives of Ophthalmology

Volumn 117, Issue 12, 1999, Pages 1593-1599

  Dushku, Nicholas ^d   Hatcher, Sandra L S ^a   Albert, Daniel M ^b   Reid, Ted W ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of Wisconsin Health   (United States)

^c TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

^d KAISER PERMANENTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; VIRUS DNA;

APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONSENSUS SEQUENCE; CONTROLLED STUDY; CORNEA DISEASE; CORNEA TUMOR; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN TISSUE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PTERYGIUM; ULTRAVIOLET RADIATION; VIRUS INFECTION; WART VIRUS;

EID: 0033404833     PISSN: 00039950     EISSN: None     Source Type: Journal    
DOI: 10.1001/archopht.117.12.1593     Document Type: Article

References (69)

1. Dushku N, Tyler N, Reid TW. Immunohistochemical evidence that pterygia arise from altered limbal epithelial basal stem cells [abstract]. Invest Ophthalmol Vis Sci. 1993;34:S1013.
2. Dushku N, Reid TW. Immunohistochemical evidence that human pterygia originate from an invasion of vimentin-expressing altered limbal epithelial basal cells. Curr Eye Res. 1994;13:473-481.
3. Cameron ME. Geographic distribution of pterygia. Trans Ophthalmol Soc Aust. 1962;22:67-81.
4. Taylor HR, West SK, Rosenthal FS, Munoz BM, Newland HS, Emmett EA. Corneal changes associated with chronic UV irradiation. Arch Ophthalmol. 1989; 107:1481-1484.
5. Duke-Elder S. Diseases of the outer eye. In: System of Ophthalmology. Vol 8. Part 1. St Louis, Mo: CV Mosby; 1965:573-582.
6. Cha SB, Shields JA, Shields CL, Wang MX. Squamous cell carcinoma of the conjunctiva. In: Shields JA, ed. International Ophthalmology Clinics. Vol 33. Boston, Mass: Little Brown & Co Inc; 1993:19-24.
7. Tabbara KF, Kersten R, Daouk N, Blodi FC. Metastatic spuamous cell carcinoma of the conjunctiva. Ophthalmology. 1988;95:318-321.
8. Clear AS, Chirambo MC, Hutt MSR. Solar keratosis, pterygium, and squamous cell carcinoma of the conjunctiva in Malawi. Br J Ophthalmol. 1979;63:102-109.
9. Brash DE, Rudolph JA, Simon JA, et al. A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc Natl Acad Sci U S A. 1991;88:10124-10128.
10. Kress S, Sutter C, Strickland PT, Mukhtar H, Schweizer J, Schwartz M. Carcinogen-specific mutational pattern in the p53 gene in ultraviolet B radiation-induced squamous cell carcinomas of mouse skin. Cancer Res. 1992;52:6400-6403.
11. Vogelstein B, Kinzler KW. Carcinogens leave fingerprints. Nature 1992;355:209-210.
12. Ziegler A, Leffell DJ, Kunala S, et al. Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers. Proc Natl Acad Sci U S A. 1993;90: 4216-4220.
13. Dushku N, Reid TW. p53 expression in altered limbal basal cells of pingueculae, pterygia, and limbal tumors. Curr Eye Res. 1997;16:1179-1192.
14. Kinzler KW, Vogelstein B. Life (and death) in a malignant tumour. Nature. 1996; 379:19-20.
15. Weinberg RA. Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis. Cancer Res. 1996;49:3713-3721.
16. Werness BA, Levine AJ, Howley PM, Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science. 1990;248:76-79.
17. Scheffner M, Werness BA, Huibregste JM, Levine AJ, Howley PM. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell. 1990;63:1129-1136.
18. Tommasino M, Crawford L. Human papillomavirus E6 and E7: proteins which deregulate the cell cycle. Bioessays. 1995;17:509-518.
19. Kessis TD, Slebos RJ, Nelson WG, et al. Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage. Proc Natl Acad Sci U S A. 1993;90:3988-3992.
20. Foster SA, Demers GW, Etscheid BG, Galloway DA. The ability of human papillomavirus E6 proteins to target p53 for degradation in vivo correlates with their ability to abrogate actinomycin D-induced growth arrest. J Virol. 1994;68:5698-5705.
21. Barten M, Ostwald C, Milde-Langosch K, Muller P. Wukasch Y, Loning T. HPV DNA and p53 alterations in oropharyngeal carcinomas. Virchows Arch. 1995; 427:153-157.
22. Lam KY, Chan AC, Chan KW, Leung ML, Srivastava G. Expression of p53 and its relationship with human papillomavirus in penile carcinomas. Eur J Surg Oncol. 1995;21:613-616.
23. Akasofu M, Oda Y. Immunohistochemical detection of p53 in cervical epithelial lesions with or without infection of human papillomavirus types 16 and 18. Virchows Arch. 1995;425:593-602.
24. He D, Zhang DK, Lam KY, et al. Prevalence of HPV infection in esophageal squamous cell carcinoma in Chinese patients and its relationship to the p53 gene mutation. Int J Cancer. 1997;72:959-964.
25. Ngan HY, Tsao SW, Liu SS, Stanley M. Abnormal expression and mutation of p53 in cervical cancer: a study at protein, RNA and DNA levels. Genitourin Med. 1997;73:54-58.
26. Markowska J, Nowak M, Bar M, Harlozinska A. Expression of p53 and coexistence of HPV in premalignant lesions and in cervical cancer. Eur J Gynaecol Oncol. 1995;16:368-372.
27. Dolmetsch AM, Alcocer CE, Scull JJ, Martins MC, Stockl FA, Burnier MN. The presence of human papilloma virus in pterygia [abstract]. Invest Ophthalmol Vis Sci. 1996;37:S43.
28. McDonnell JM, McDonnell PJ, Sun YY. Human papillomavirus DNA in tissues and ocular surface swabs of patients with conjunctival epithelial neoplasia. Invest Ophthalmol Vis Sci. 1992;33:184-189.
29. Alcocer CB, Scull JJ, Martins MC, et al. The presence of human papilloma virus in association with epithelial neoplasia of the conjunctiva [abstract]. Invest Ophthalmol Vis Sci. 1996;37:S625.
30. Karcioglu ZA, Issa TM. Human papilloma virus in neoplastic and non-neoplastic conditions of the external eye. Br J Ophthalmol. 1997;81:595-598.
31. Tabrizi SN, McCurrach FE, Drewe RH, Borg AJ, Garland SM, Taylor HR. Human papillomavirus incorneal and conjunctival carcinoma. Aust N Z J Ophthalmol. 1997;25:211-215.
32. Dushku N, Albert DM, Reid TW. The use of PCR to test for human papilloma virus DNA in p53 expressing limbal stem cells of pinguecula, pterygia, and limbal tumors [abstract]. Invest Ophthalmol Vis Sci. 1998;39:S543.
33. Vojtesek B, Bartek J, Midgley CA, Lane DP. An immunochemical analysis of the human nuclear phosphoprotein p53. J Immunol Methods. 1992;151:237-244.
34. Man YG, Tavassoli FA. A simple epitope retrieval method without the use of microwave oven or enzyme digestion. Appl Immunohistochem. 1996;4:139-141.
35. Taylor CR, Shi SR, Chaiwun S, Young L, Imam SA, Cote RJ. Strategies for improving the immunohistochemical staining of various intranuclear prognostic markers in formalin-paraffin sections: androgen receptor, estrogen receptor, progesterone receptor, p53 protein, proliferating cell nuclear antigen, and Ki-67 antigen revealed by antigen retrieval techniques. Hum Pathol. 1994;25:263-270.
36. Lovelace C, Zhang J, Vanek P, Collier G. Detecting apoptotic cells in situ. Biomed Prod. 1996;21:76-77.
37. Ting Y, Manos MM. Detection and typing of genital human papillomavirus. In: PCR Protocols: A Guide to Methods and Applications, Orlando, Fla: Academic Press Inc; 1990:356-367.
38. Spencer WH. Ophthalmic Pathology: An Atlas and Textbook. 3rd ed. Philadelphia. Pa: WB Saunders Co; 1985.
39. Blum HF. Carcinogenesis by Ultraviolet Light. Princeton, NJ: Princeton University Press; 1959.
40. Buschke W, Friedenwald JS, Moses SG. Effects of ultraviolet irradiation on corneal epithelium: mitosis, nuclear fragmentation, post-traumatic cell movements, loss of tissue cohesion. J Cell Compr Physiol. 1945;26:147-164.
41. Coroneo MT, Filipic M. Focal elastotic degeneration in the angle and ciliary body of eyes with pterygia [abstract]. Invest Ophthalmol Vis Sci. 1997;39:S1082.
42. Schermer A, Galvin S, Sun TT. Differentiation-related expression of a major 64K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cells. J Cell Biol. 1986;103:49-62.
43. Wei ZG. Wu RL, Lavker RM, Sun TT. In vitro growth and differentiation of rabbit bulbar, fornix, and palpebral conjunctival epithelia: implications on conjunctival epithelial transdifferentiation and stem cells. Invest Ophthalmol Vis Sci. 1993;34:1814-1828.
44. Lavker RM, Dong G, Cheng SZ, Kudoh K, Costarelis G, Sun TT. Relative proliferative rates of limbal and corneal epithelia: implications of corneal epithelial migration, circadian rhythm, and suprabasally located DNA-synthesizing keratinocytes. Invest Ophthalmol Vis Sci. 1991;32:1864-1875.
45. Miller SJ, Lavker RM, Sun TT. Keratinocyte stem cells of cornea, skin and hair follicle: common and distinguishing features. Dev Biol. 1993;4:217-240.
46. Jakobiec SA. Corneal tumors. In: Kaufman H, Barron BA, McDonald MB, Waltman SR, eds. The Cornea. London, England: Churchill Livingstone Inc; 1988:563-598.
47. Cotran RS, Kumar V, Robbins SL. Robbins Pathologic Basis of Disease. 4th ed. Philadelphia, Pa: W8 Saunders Co; 1989:832-834.
48. Gigi-Leitner O, Geiger B, Levy R, Czemobilsky B. Cytokeratin expression in squamous metaplasia of the human uterine cervix. Differentiation. 1986;31:191-205.
49. Reid TW, Dushku N. Pterygia and limbal epithelial cells: relationship and molecular mechanisms. Prog Retin Eye Res. 1996;15:297-329.
50. Dushku N, Albert DM, Reid TW. Classification of p53 expression in limbal-cells of pingueculae, pterygia, and premalignant and malignant limbal tumors [abstract]. Invest Ophthalmol Vis Sci. 1997;38:S1082.
51. Coroneo MT. Pterygium as an early indicator of ultraviolet insolation: a hypothesis. Br J Ophthalmol. 1993;77:734-739.
52. Dushku N, Reid TW. Immunohistochemical evidence that pterygia originate from Rb and TGFβ-expressing, p53-transformed, limbal basal stem cells. Invest Ophthalmol Vis Sci. 1995;36:S1027.
53. Kria L, Ohira A, Amemiya T. Immunohistochemical localization of basic fibroblast growth factor, platelet derived growth factor, transforming growth factor-β and tumor necrosis factor-α in the pterygium. Acta Histochem. 1996;98:195-201.
54. Ren X, Liu YP, Tan DTH, Schultz GS. Elevated expression of TGFβ and EGF system in pterygia tissues and matched superior conjunctiva [abstract]. Invest Ophthalmol Vis Sci. 1998;39:5509.
55. Pasquale LR, Dorman-Pease ME, Lutty GA, Quigley HA, Jampel HD. Immunolocalization of TGF-β1, TGF-β2, and TGF-β3 in the anterior segment of the human eye. Invest Ophthalmol Vis Sci. 1993;34:23-30.
56. Roberts AB, Sporn MB, Assoian RK, Smith JM, Roche NS, Wakefield LM. Transforming growth factor type β: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci U S A. 1986;83:416-417.
57. Liotta LA, Stetler-Stevenson W, Steeg PS. Metastasis suppressor genes. In: DeVita VT, Hellman S, Rosenberg SA, eds. Oncology. Philadelphia, Pa: JB Lippincott; 1991:85-100.
58. Seiffert P, Sekundo W. Capillaries in the epithelium of pterygium. Br J Ophthalmol. 1998;82:77-81.
59. Dameron KM, Volpert OV, Tainsky A, Bouck N. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science. 1994;265:1582-1584.
60. Kay EP, Lee HK, Park KS, Lee SC. Indirect mitogenic effect of transforming growth factor-β on cell proliferation of subconjunctival fibroblasts. Invest Ophthalmol Vis Sci. 1998;39:481-486.
61. Van der Zee E, Everts V, Beertsen W. Cytokines modulate routes of collagen breakdown. J Clin Periodontol. 1997;24:297-305.
62. Salo T, Lyons JG, Rahemtulia F. Birkedal-Hansen H. Transforming growth factor-β1 up-regulatestype IV collagenase expression in cultured human keratinocytes. J Biol Chem. 1991;266:11436-11441.
63. Fini ME, Girard MT, Matsubara M, Bartlett JD. Unique regulation of the matrix metalloproteinase, gelatinase B. Invest Ophthalmol Vis Sci. 1995;36:622-633.
64. Giannelli G, Falk-Marzillier J, Schiraldi O, Stetler-Stevenson WG, Quarante V. Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5. Science. 1997;277:225-228.
65. Liu YP, Schultz GS, Ren XO, Tan DTH. MMP2 and MMP9 levels in pterygia and matched superior conjunctiva by gelatin zymography [abstract]. Invest Ophthalmol Vis Sci. 1998;39:S756.
66. Baron S, Tyring SK, Fleischmann WR, et al. The interferons: mechanisms of action and clinical applications, JAMA. 1991;266:1375-1383.
67. Maskin SL. Regression of limbal epithelial dysplasia with topical Interferon [letter]. Arch Ophthalmol. 1994;112:1145-1146.
68. Fung-Rong H, Ming-Jet W, Sow-Hsong K. Interferon treatment for corneolimbal squamous dysplasia. Am J Ophthalmol. 1998;125:118-119.
69. Vann RR, Karp CL. Perilesional and topical Interferon alfa 2-β for conjunctival and corneal neoplasia [abstract]. Invest Ophthalmol Vis Sci. 1998;39:S711.