-
1
-
-
58549091682
-
Prognostic value of minimal residual disease quantification before allogeneic stem-cell transplantation in relapsed childhood acute lymphoblastic leukemia: The ALL-REZ BFM Study Group
-
Bader P, Kreyenberg H, Henze GH et al. Prognostic value of minimal residual disease quantification before allogeneic stem-cell transplantation in relapsed childhood acute lymphoblastic leukemia: the ALL-REZ BFM Study Group. J. Clin. Oncol. 27(3), 377-384 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, Issue.3
, pp. 377-384
-
-
Bader, P.1
Kreyenberg, H.2
Henze, G.H.3
-
2
-
-
76749095066
-
Long-term results of the childrens cancer group studies for childhood acute lymphoblastic leukemia 1983-2002: A Childrens Oncology Group Report
-
Gaynon PS, Angiolillo AL, Carroll WL et al. Long-term results of the childrens cancer group studies for childhood acute lymphoblastic leukemia 1983-2002: a Childrens Oncology Group Report. Leukemia 24(2), 285-297 (2009).
-
(2009)
Leukemia
, vol.24
, Issue.2
, pp. 285-297
-
-
Gaynon, P.S.1
Angiolillo, A.L.2
Carroll, W.L.3
-
3
-
-
77952483774
-
Long-term outcome in children with relapsed acute lymphoblastic leukemia after time-point and site-of-relapse stratification and intensified short-course multidrug chemotherapy: Results of trial ALL-REZ BFM 90
-
Tallen G, Ratei R, Mann G et al. Long-term outcome in children with relapsed acute lymphoblastic leukemia after time-point and site-of-relapse stratification and intensified short-course multidrug chemotherapy: results of trial ALL-REZ BFM 90. J. Clin. Oncol. 28(14), 2339-2347 (2010).
-
(2010)
J. Clin. Oncol.
, vol.28
, Issue.14
, pp. 2339-2347
-
-
Tallen, G.1
Ratei, R.2
Mann, G.3
-
4
-
-
77951441599
-
Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: Results in 3184 patients of the AIEOP-BFM ALL 2000 study
-
Conter V, Bartram CR, Valsecchi MG et al. Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: results in 3184 patients of the AIEOP-BFM ALL 2000 study. Blood 115(16), 3206-3214 (2010).
-
(2010)
Blood
, vol.115
, Issue.16
, pp. 3206-3214
-
-
Conter, V.1
Bartram, C.R.2
Valsecchi, M.G.3
-
5
-
-
77951191165
-
Prospective evaluation of MRD-kinetics in 274 children with high-risk ALL treated in trial ALL-BFM 2000: Insights into development of resistance and impact on further refinement of treatment stratification strategies
-
Schrauder A, Stanulla M, Flohr T et al. Prospective evaluation of MRD-kinetics in 274 children with high-risk ALL treated in trial ALL-BFM 2000: insights into development of resistance and impact on further refinement of treatment stratification strategies. Blood 585a (2007).
-
(2007)
Blood
, vol.585
-
-
Schrauder, A.1
Stanulla, M.2
Flohr, T.3
-
6
-
-
77953026387
-
The role of the innovative therapies for children with cancer (ITCC) European consortium
-
Zwaan CM, Kearns P, Caron H et al. The role of the innovative therapies for children with cancer (ITCC) European consortium. Cancer Treat. Rev. 36(4), 328-334 (2010).
-
(2010)
Cancer Treat. Rev.
, vol.36
, Issue.4
, pp. 328-334
-
-
Zwaan, C.M.1
Kearns, P.2
Caron, H.3
-
7
-
-
34447249881
-
The pediatric preclinical testing program: Description of models and early testing results
-
Houghton PJ, Morton CL, Tucker C et al. The pediatric preclinical testing program: description of models and early testing results. Pediatric Blood Cancer 49(7), 928-940 (2007).
-
(2007)
Pediatric Blood Cancer
, vol.49
, Issue.7
, pp. 928-940
-
-
Houghton, P.J.1
Morton, C.L.2
Tucker, C.3
-
8
-
-
77951171023
-
Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance
-
Bonapace L, Bornhauser BC, Schmitz M et al. Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance. J. Clin. Invest. 120(4), 1310-1323 (2010).
-
(2010)
J. Clin. Invest.
, vol.120
, Issue.4
, pp. 1310-1323
-
-
Bonapace, L.1
Bornhauser, B.C.2
Schmitz, M.3
-
9
-
-
51349108718
-
Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells
-
Kharas MG, Janes MR, Scarfone VM et al. Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. J. Clin. Invest. 118(9), 3038-3050 (2008).
-
(2008)
J. Clin. Invest.
, vol.118
, Issue.9
, pp. 3038-3050
-
-
Kharas, M.G.1
Janes, M.R.2
Scarfone, V.M.3
-
10
-
-
45849102392
-
In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties
-
le Viseur C, Hotfilder M, Bomken S et al. In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties. Cancer Cell 14(1), 47-58 (2008).
-
(2008)
Cancer Cell
, vol.14
, Issue.1
, pp. 47-58
-
-
Le Viseur, C.1
Hotfilder, M.2
Bomken, S.3
-
11
-
-
2342531648
-
Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies
-
Liem NL, Papa RA, Milross CG et al. Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies. Blood 103(10), 3905-3914 (2004).
-
(2004)
Blood
, vol.103
, Issue.10
, pp. 3905-3914
-
-
Liem, N.L.1
Papa, R.A.2
Milross, C.G.3
-
12
-
-
31544443832
-
The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL
-
Teachey DT, Obzut DA, Cooperman J et al. The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL. Blood 107(3), 1149-1155 (2006).
-
(2006)
Blood
, vol.107
, Issue.3
, pp. 1149-1155
-
-
Teachey, D.T.1
Obzut, D.A.2
Cooperman, J.3
-
13
-
-
77955641907
-
Leukemia-initiating cells are frequent in very high risk childhood acute lymphoblastic leukemia and give rise to relatively stable phenotypes in immunodeficient mice
-
86a
-
Schmitz M, Mirkowska P, Breithaupt P et al. Leukemia-initiating cells are frequent in very high risk childhood acute lymphoblastic leukemia and give rise to relatively stable phenotypes in immunodeficient mice. Blood 114(22), 86a (2009).
-
(2009)
Blood
, vol.114
, pp. 22
-
-
Schmitz, M.1
Mirkowska, P.2
Breithaupt, P.3
-
15
-
-
44449147036
-
Tumor cell metabolism: Cancers Achilles heel
-
Kroemer G, Pouyssegur J. Tumor cell metabolism: cancers Achilles heel. Cancer Cell 13(6), 472-482 (2008).
-
(2008)
Cancer Cell
, vol.13
, Issue.6
, pp. 472-482
-
-
Kroemer, G.1
Pouyssegur, J.2
-
16
-
-
15244341393
-
Dexamethasone resistance in B-cell precursor childhood acute lymphoblastic leukemia occurs downstream of ligand-induced nuclear translocation of the glucocorticoid receptor
-
Bachmann PS, Gorman R, Mackenzie KL, Lutze-Mann L, Lock RB. Dexamethasone resistance in B-cell precursor childhood acute lymphoblastic leukemia occurs downstream of ligand-induced nuclear translocation of the glucocorticoid receptor. Blood 105(6), 2519-2526 (2005).
-
(2005)
Blood
, vol.105
, Issue.6
, pp. 2519-2526
-
-
Bachmann, P.S.1
Gorman, R.2
MacKenzie, K.L.3
Lutze-Mann, L.4
Lock, R.B.5
-
17
-
-
34548850030
-
Low-dose arsenic trioxide sensitizes glucocorticoid-resistant acute lymphoblastic leukemia cells to dexamethasone via an Akt-dependent pathway
-
Bornhauser BC, Bonapace L, Lindholm D et al. Low-dose arsenic trioxide sensitizes glucocorticoid-resistant acute lymphoblastic leukemia cells to dexamethasone via an Akt-dependent pathway. Blood 110(6), 2084-2091 (2007).
-
(2007)
Blood
, vol.110
, Issue.6
, pp. 2084-2091
-
-
Bornhauser, B.C.1
Bonapace, L.2
Lindholm, D.3
-
18
-
-
33749443714
-
Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance
-
Wei G, Twomey D, Lamb J et al. Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance. Cancer Cell 10(4), 331-342 (2006).
-
(2006)
Cancer Cell
, vol.10
, Issue.4
, pp. 331-342
-
-
Wei, G.1
Twomey, D.2
Lamb, J.3
-
19
-
-
20444486559
-
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
-
Oltersdorf T, Elmore SW, Shoemaker AR et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 435(7042), 677-681 (2007).
-
(2007)
Nature
, vol.435
, Issue.7042
, pp. 677-681
-
-
Oltersdorf, T.1
Elmore, S.W.2
Shoemaker, A.R.3
-
20
-
-
44849112219
-
ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor
-
Tse C, Shoemaker AR, Adickes J et al. ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res. 68(9), 3421-3428 (2008).
-
(2008)
Cancer Res.
, vol.68
, Issue.9
, pp. 3421-3428
-
-
Tse, C.1
Shoemaker, A.R.2
Adickes, J.3
-
21
-
-
77149178712
-
The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergistic in vitro and in vivo interactions with established drugs
-
High LM, Szymanska B, Wilczynska-Kalak U et al. The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergistic in vitro and in vivo interactions with established drugs. Mol. Pharmacol. 77(3), 483-494 (2010).
-
(2010)
Mol. Pharmacol.
, vol.77
, Issue.3
, pp. 483-494
-
-
High, L.M.1
Szymanska, B.2
Wilczynska-Kalak, U.3
-
22
-
-
42349109916
-
Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program
-
DOI 10.1002/pbc.21433
-
Lock R, Carol H, Houghton PJ et al. Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program. Pediatric Blood Cancer 50(6), 1181-1189 (2008). (Pubitemid 351555542)
-
(2008)
Pediatric Blood and Cancer
, vol.50
, Issue.6
, pp. 1181-1189
-
-
Lock, R.1
Carol, H.2
Houghton, P.J.3
Morton, C.L.4
Anders Kolb, E.5
Gorlick, R.6
Patrick Reynolds, C.7
Maris, J.M.8
Keir, S.T.9
Wu, J.10
Smith, M.A.11
-
23
-
-
41349123507
-
BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia
-
Del Gaizo Moore V, Schlis KD, Sallan SE, Armstrong SA, Letai A. BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia. Blood 111(4), 2300-2309 (2008).
-
(2008)
Blood
, vol.111
, Issue.4
, pp. 2300-2309
-
-
Del Gaizo Moore, V.1
Schlis, K.D.2
Sallan, S.E.3
Armstrong, S.A.4
Letai, A.5
-
24
-
-
77955643496
-
Use of human cancer cell lines mitochondria to explore the mechanisms of BH3 peptides and ABT-737-induced mitochondrial membrane permeabilization
-
Buron N, Porceddu M, Brabant M et al. Use of human cancer cell lines mitochondria to explore the mechanisms of BH3 peptides and ABT-737-induced mitochondrial membrane permeabilization. PloS One 5(3), e9924 (2010).
-
(2010)
PloS One
, vol.5
, Issue.3
-
-
Buron, N.1
Porceddu, M.2
Brabant, M.3
-
25
-
-
34548814971
-
Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo
-
Kang MH, Kang YH, Szymanska B et al. Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo. Blood 110(6), 2057-2066 (2007).
-
(2007)
Blood
, vol.110
, Issue.6
, pp. 2057-2066
-
-
Kang, M.H.1
Kang, Y.H.2
Szymanska, B.3
-
26
-
-
33750628289
-
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
-
Konopleva M, Contractor R, Tsao T et al. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell 10(5), 375-388 (2006).
-
(2006)
Cancer Cell
, vol.10
, Issue.5
, pp. 375-388
-
-
Konopleva, M.1
Contractor, R.2
Tsao, T.3
-
27
-
-
77951442337
-
Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1
-
Yecies D, Carlson NE, Deng J, Letai A. Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1. Blood 115(16), 3304-3313 (2010).
-
(2010)
Blood
, vol.115
, Issue.16
, pp. 3304-3313
-
-
Yecies, D.1
Carlson, N.E.2
Deng, J.3
Letai, A.4
-
28
-
-
37649023004
-
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
-
Nguyen M, Marcellus RC, Roulston A et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc. Natl Acad. Sci. USA 104(49), 19512-19517 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, Issue.49
, pp. 19512-19517
-
-
Nguyen, M.1
Marcellus, R.C.2
Roulston, A.3
-
29
-
-
42249102086
-
Identification of RIP1 kinase as a specific cellular target of necrostatins
-
Degterev A, Hitomi J, Germscheid M et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat. Chem. Biol. 4(5), 313-321 (2008).
-
(2008)
Nat. Chem. Biol.
, vol.4
, Issue.5
, pp. 313-321
-
-
Degterev, A.1
Hitomi, J.2
Germscheid, M.3
-
30
-
-
0038731167
-
Caspase-independent cell death in T lymphocytes
-
Jaattela M, Tschopp J. Caspase-independent cell death in T lymphocytes. Nat. Immunol. 4(5), 416-423 (2003).
-
(2003)
Nat. Immunol.
, vol.4
, Issue.5
, pp. 416-423
-
-
Jaattela, M.1
Tschopp, J.2
-
31
-
-
55949083821
-
FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells
-
Bell BD, Leverrier S, Weist BM et al. FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells. Proc. Natl Acad. Sci. USA 105(43), 16677-16682 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, Issue.43
, pp. 16677-16682
-
-
Bell, B.D.1
Leverrier, S.2
Weist, B.M.3
-
32
-
-
57649181391
-
Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway
-
Hitomi J, Christofferson DE, Ng A et al. Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell 135(7), 1311-1323 (2008).
-
(2008)
Cell
, vol.135
, Issue.7
, pp. 1311-1323
-
-
Hitomi, J.1
Christofferson, D.E.2
Ng, A.3
-
33
-
-
51849111524
-
NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations
-
Serra V, Markman B, Scaltriti M et al. NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations. Cancer Res. 68(19), 8022-8030 (2008).
-
(2008)
Cancer Res.
, vol.68
, Issue.19
, pp. 8022-8030
-
-
Serra, V.1
Markman, B.2
Scaltriti, M.3
-
34
-
-
58849164097
-
Phase i study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia
-
OBrien SM, Claxton DF, Crump M et al. Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia. Blood 113(2), 299-305 (2008).
-
(2008)
Blood
, vol.113
, Issue.2
, pp. 299-305
-
-
Obrien, S.M.1
Claxton, D.F.2
Crump, M.3
-
35
-
-
78149410044
-
A Phase i study of obatoclax mesylate, a Bcl-2 antagonist, plus topotecan in solid tumor malignancies
-
DOI: 10.1007/s00280-010-1265-5 Epub ahead of print
-
Paik PK, Rudin CM, Brown A et al. A Phase I study of obatoclax mesylate, a Bcl-2 antagonist, plus topotecan in solid tumor malignancies. Cancer Chemother. Pharmacol. DOI: 10.1007/s00280-010-1265-5 (2010) (Epub ahead of print).
-
(2010)
Cancer Chemother. Pharmacol.
-
-
Paik, P.K.1
Rudin, C.M.2
Brown, A.3
-
36
-
-
40749106485
-
Apoptosis in leukemia: From molecular pathways to targeted therapies
-
Schimmer AD. Apoptosis in leukemia: from molecular pathways to targeted therapies. Best Pract. Res. Clin. Haematol. 221(1), 5-11 (2009).
-
(2009)
Best Pract. Res. Clin. Haematol.
, vol.221
, Issue.1
, pp. 5-11
-
-
Schimmer, A.D.1
|