Oxygen free radicals regulate energy metabolism via AMPK pathway following cerebral ischemia

Neurological Research

Volumn 32, Issue 7, 2010, Pages 779-784

  Li, Meng ^a,b   Zhao, Jie ^a   Hu, Yun ^a   Lu, Hongbiao ^a   Guo, Jun ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b CHILDREN S HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

AMPK; Cerebral ischemia; GLUT4; NMDA receptor; oxygen free radical

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA TOCOPHEROL; FREE RADICAL; GLUCOSE TRANSPORTER 4; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; KETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; OXYGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CELL MEMBRANE; CONTROLLED STUDY; ENERGY METABOLISM; HIPPOCAMPUS; IMMUNOBLOTTING; MALE; NONHUMAN; PROTEIN TRANSPORT; RAT; REPERFUSION; SPRAGUE DAWLEY RAT;

ALPHA-TOCOPHEROL; AMP-ACTIVATED PROTEIN KINASES; ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; BRAIN ISCHEMIA; ENERGY METABOLISM; GLUCOSE TRANSPORTER TYPE 4; HIPPOCAMPUS; KETAMINE; MALE; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 77955619413     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/174313209X459174     Document Type: Article

References (24)

1. Agnetti G, Maraldi T, Fiorentini D, et al. Activation of glucose transport during simulated ischemia in H9c2 cardiac myoblasts is mediated by protein kinase C isoforms. Life Sci 2005; 78: 264-270
2. Anderson KA, Ribar TJ, Lin F, et al. Hypothalamic CaMKK2 contributes to the regulation of energy balance. Cell Metab 2008; 7: 377-388
3. Carling D. AMPK-activated protein kinase: Balancing the scales. Biochimie (Paris) 2005; 87: 87-91
4. Corasaniti MT, Maiuolo J, Maida S, et al. Cell signaling pathways in the mechanisms of neuroprotection afforded by bergamot essential oil against NMDA-induced cell death in vitro. Br J Pharmacol 2007; 151: 518-529
5. Grammer M, Li D, Arunthavasothy N, et al. Contribution of calpain activation to early stages of hippocampal damage during oxygen-glucose deprivation. Brain Res 2008; 1196: 121-130
6. Guo J, Wu HW, Hu G, et al. Sustained activation of Src-family tyrosine kinases by ischemia: A potential mechanism mediating extracellular signal-regulated kinase cascades in hippocampal dentate gyrus. Neurosci 2006; 143: 827-836
7. Hardie DG. The AMP-activated protein kinase cascade: The key sensor of cellular energy status. Endocrinology 2003; 144: 5179-5183
8. Hernández-Fonseca K, Cárdenas-Rodríguez N, Pedraza-Chaverri J, et al. Calcium-dependent production of reactive oxygen species is involved in neuronal damage induced during glycolysis inhibition in cultured hippocampal neurons. J Neurosci Res 2008; 86: 1768-1780
9. Horie T, Ono K, Nagao K, et al. Oxidative stress induces GLUT4 translocation by activation of PI3-K/Akt and dual AMPK kinase in cardiac myocytes. J Cell Physiol 2008; 215: 733-742
10. Hurley RL, Anderson KA, Franzone JM, et al. The Ca2z/ calmodulin-dependent protein kinase kinases are AMPK activated protein kinase kinases. J Biol Chem 2005; 280: 29060-29066
11. Jung SN, Yang WK, Kim J, et al. Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells. Carcinogenesis 2008; 29: 713-721
12. Kemp BE, Mitchelhill KI, Stapleton D, et al. Dealing with energy demand: The AMPK-activated protein kinase. Trends Biochem Sci 1999; 24: 22-25
13. Leff T. AMP-activated protein kinase regulates gene expression by direct phosphorylation of nuclear proteins. Biochem Soc Trans 2003; 31: 224-227
14. Lipton SA, Rosenberg PA. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 1994; 330: 613-622
15. Lopaschuk GD. AMP-activated protein kinase control of energy metabolism in the ischemic heart. Int J Obes (Lond) 2008; 32 (Suppl. 4): S29-S35
16. Love S. Apoptosis and brain ischaemia. Prog Neuropsychopharmacol Biol Psychiatry 2003; 27: 267-282
17. Mehta SL, Manhas N, Raghubir R. Molecular targets in cerebral ischemia for developing novel therapeutics. Brain Res Rev 2007; 54: 34-66
18. Mu J, Brozinick JT, Jr, Valladares O, et al. A role for AMPactivated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle. Mol Cell 2001; 7: 1085-1094
19. Nishiumi S, Ashida H. Rapid preparation of a plasma membrane fraction from adipocytes and muscle cells: Application to detection of translocated glucose transporter 4 on the plasma membrane. Biosci Biotechnol Biochem 2007; 71: 2343-2346
20. Papadia S, Hardingham GE. The dichotomy of NMDA receptor signaling. Neuroscientist 2007; 13: 572-579
21. Russell RR, 3rd, Li J, Coven DL, et al. AMPK activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury. J Clin Invest 2004; 114: 495-503
22. Sakoda H, Ogihara T, Anai M, et al. Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes. Am J Physiol Endocrinol Metab 2002; 282: 1239-1244
23. Woods A, Azzout-Marniche D, Foretz M, et al. Characterization of the role ofAMP-activated protein kinase in the regulation of glucoseactivated gene expression using constitutively active and dominant negative forms of the kinase. Mol Cell Biol 2000; 20: 6704-6711
24. Wu HW, Li HF, Wu XY, et al. Reactive oxygen species mediate ERK activation through different Raf-1-dependent signaling pathways following cerebral ischemia. Neurosci Lett 2008; 432: 83-87