Late-occurring pulmonary pathologies following inhalation of mixed oxide (Uranium + Plutonium oxide) aerosol in the rat

Health Physics

Volumn 99, Issue 3, 2010, Pages 347-356

  Griffiths, N M ^a   Van Der Meeren, A ^a   Fritsch, P ^a   Abram, M C ^a   Bernaudin, J F ^b   Poncy, J L ^a  

^a INSTITUT DE RADIOBIOLOGIE CELLULAIRE ET MOLÉCULAIRE   (France)

^b HÔPITAL TENON   (France)

Author keywords

actinides; cancer; health effects; lungs; rodent

Indexed keywords

PLUTONIUM; PLUTONIUM DIOXIDE; URANIUM DERIVATIVE; URANIUM OXIDE; AEROSOL;

AEROSOL; ANIMAL; BODY BURDEN; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CONFERENCE PAPER; DRUG EFFECT; IMMUNOHISTOCHEMISTRY; INHALATIONAL DRUG ADMINISTRATION; LIVER CIRRHOSIS; LUNG; LUNG TUMOR; MALE; METABOLISM; PATHOLOGY; RADIATION EXPOSURE; RADIATION RESPONSE; RAT; SPRAGUE DAWLEY RAT; TIME; CHEMICALLY INDUCED; DRUG EFFECTS; TOXICITY;

ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; BODY BURDEN; DOSE-RESPONSE RELATIONSHIP, RADIATION; IMMUNOHISTOCHEMISTRY; LIVER CIRRHOSIS; LUNG; LUNG NEOPLASMS; MALE; PLUTONIUM; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; URANIUM COMPOUNDS;

RATTUS; RODENTIA;

EID: 77955605627     PISSN: 00179078     EISSN: None     Source Type: Journal    
DOI: 10.1097/HP.0b013e3181c75750     Document Type: Conference Paper

References (44)

1. Andre S, Charuau J, Rateau G, Vavasseur C, Metivier H. Design of a new inhalation device for rodent and primates. J Aerosol Sci 20:647- 656; 1989.
2. Boorman GA, Brockmann M, Carlton WW, Davis JM, Dungworth DL, Hahn FF, Mohr U, Reichhelm HB, Turusov VS, Wagner BM. Classification of cystic keratinizing squamous lesions of the rat lung: report of a workshop. Toxicol Pathol 24:564 -572; 1996.
3. Chen YC, Hsu HS, Chen YW, Tsai TH, How CK, Wang CY, Hung SC, Chang YL, Tsai ML, Lee YY, Ku HH, Chiou SH. Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells. PLoS ONE 37:e2637; 2008.
4. Chiou SH, Yu CC, Huang CY, Lin SC, Liu CJ, Tsai TH, Chou SH, Chien CS, Ku HH, Lo JF. Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high grade oral squamous cell carcinoma. Clin Cancer Res 14:4085- 4095; 2008.
5. Dagle GE, Park JF, Gilbert ES, Weller RE. Risk estimates for lung tumours from inhaled 239PuO2, 238PuO2 and 239Pu(NO3)4 in beagle dogs. Radiat Protect Dosim 26:173-176; 1989.
6. Diel JH, Guilmette RA, Muggenburg BA, Hahn FF, Chang IY. Influence of dose rate on survival time for 239PuO2-induced radiation pneumonitis or pulmonary fibrosis in dogs. Radiat Res 129:53- 60; 1992.
7. Dudoignon N, Guillet K, Rateau G, Fritsch P. Survival, lung clearance, dosimetry and gross pathology of rats exposed to either NpO2 or PuO2 aerosols. Int J Radiat Biol 77:979 -990; 2001.
8. Dudoignon N, Guillet K, Fritsch P. Evaluation of risk factors for lung tumour induction in rats exposed to either NpO2 or PuO2 aerosols. Int J Radiat Biol 79:169 -174; 2003.
9. Eidson AF, Mewhinney JA. In vitro dissolution of respirable aerosols of industrial uranium and plutonium mixed-oxide nuclear fuels. Health Phys 45:1023-1037; 1983.
10. Fritsch P, Dudoignon N, Guillet K, Oghiso Y, Morlier JP, Monchaux G. Does mean lung dose calculated after inhalation of alpha emitters actually reflect the risk of induction of malignant lung tumours? Radiat Protect Dosim 105:149- 152; 2003.
11. Gonzalez RF, Allen L, Dobbs LG. Rat alveolar type I cells proliferate, express OCT-4 and exhibit phenotypic plasticity in vitro. Am J Physiol Lung Cell Mol Physiol 297:L1045- L1055; 2009.
12. Hahn FF, Boorman GA. Neoplasia and preneoplasia of the lung. In: Bannasch P, Gössner W, eds. Pathology and neoplasia in rodents. EULEP Colour Atlas Vol2. Stuttgart, Germany: Schattauer; 1997: 29-42.
13. Hahn FF, Romanov SA, Guilmette RA, Nifatov AP, Diel JH, Zaytseva Y. Plutonium microdistribution in the lungs of Mayak workers. Radiat Res 161:568 -581; 2004.
14. Herbert RA, Stegelmeier BS, Gillett NA, Rebar AH, Carlton WW, Singh G, Hahn FF. Plutonium-induced proliferative lesions and pulmonary epithelial neoplasms in the rat: immunohistochemical and ultrastructural evidence for their origin from type II pneumocytes. Vet Pathol 313:366 -374; 1994.
15. Hill RP. Radiation effects on the respiratory system. BJR Suppl 27:75- 81; 2005. Available at: http://www.ncbi.nlm.nih. gov/pubmed/15975876. Accessed 16 July 2010.
16. Jones TD, Ulbright TM, Eble JN, Baldridge LA, Cheng L. OCT4 staining in testicular tumors: a sensitive and specific marker for seminoma and embryonal carcinoma. Am J Surg Pathol 28:935-940; 2004.
17. Karoubi G, Gugger M, Schmid R, Dutly A. OCT4 expression in human non-small cell lung cancer: implications for therapeutic intervention. Interact Cardiovasc Thorac Surg 8:393-397; 2009.
18. Kim CF, Jackson EL, Woolfenden AE, Lawrence S, Babar I, Vogel S, Crowley D, Bronson RT, Jacks T. Identification of bronchioalveolar stem cells in normal lung and in lung cancer. Cell 121:823- 835; 2005.
19. Kotton DN, Summer R, Fine A. Lung stem cells: new paradigms. Exp Hematol 32:340 -343; 2004.
20. Lataillade G, Verry M, Rateau G, Métivier H, Masse R. Translocation of plutonium from rat and monkey after inhalation of industrial plutonium oxide and mixed uranium and plutonium oxide. Int J Radiat Biol 67:373-380; 1995.
21. Lee J, Kim HK, Rho JY, Han YM, Kim J. The human OCT-4 isoforms differ in their ability to confer self-renewal. J Biol Chem 281:33554 -33565; 2006.
22. Ling TY, Kuo MD, Li CL, Yu AL, Huang YH, Wu TJ, Lin YC, Chen SH, Yu J. Identification of pulmonary Oct-4- stem/ progenitor cells and demonstration of their susceptibility to SARS coronavirus (SARS-CoV) infection in vitro. Proc Natl Acad Sci USA 103:9530 -9535; 2006.
23. Marks LB, Yu X, Vujaskovic Z, Small W Jr, Folz R, Anscher MS. Radiation-induced lung injury. Semin Radiat Oncol 13:333-345; 2003.
24. Muggenburg BA, Guilmette RA, Hahn FF, Diel JH, Mauderly JL, Seilkop SK, Boecker BB. Radiotoxicity of inhaled 239PuO2 in dogs. Radiat Res 170:736 -757; 2008.
25. Newman LS, Mroz MM, Ruttenber AJ. Lung fibrosis in plutonium workers. Radiat Res 164:123-131; 2005.
26. Novakova-Jiresova A, van Luijk P, van Goor H, Kampinga HH, Coppes RP. Changes in expression of injury after irradiation of increasing volumes in rat lung. Int J Radiat Oncol Biol Phys 67:1510 -1518; 2007.
27. Oghiso Y, Yamada Y. Immunohistochemical study on cellular origins of rat lung tumors induced by inhalation exposures to plutonium dioxide aerosols as compared to those by X-ray irradiation. J Radiat Res 433:301-311; 2002.
28. Ramounet-Le Gall, Rateau G, Abram M-C, Grillon G, Ansoborlo E, Berard P, Delforge J, Fritsch P. In vivo measurements of plutonium dissolution parameters of MOX aerosols and related uncertainties in the values of the dose per unit time. Radiat Protect Dosim 105:153-156; 2003.
29. Rateau-Matton S, Ansoloborlo E, Hodgson A. Comparative absorption parameters of plutonium and Am from PuO2 and mixed oxide aerosols measured after in vitro dissolution test and inhalation in rats. Int J Radiat Biol 80:777-785; 2004.
30. Sanders CL. Deposition patterns and the toxicity of transuranium elements in the lung. Health Phys 22:607- 615; 1972.
31. Sanders CL, McDonald KE, Lauhala KE. Promotion of pulmonary carcinogenesis by plutonium particle aggregation following inhalation of 239PuO2. Radiat Res 116:393-405; 1988.
32. Sanders CL, Lauhala KE, McDonald KE. Lifespan studies in rats exposed to 239PuO2 aerosol. III. Survival and lung tumours. Int J Radiat Biol 64:417- 430; 1993a.
33. Sanders CL, Lauhala KE, McDonald KE. Sanders CL, Mc- Donald KE, Lauhala KE. Lifespan studies in rats exposed to 239PuO2 aerosol. Health Phys 64:509 -521; 1993b.
34. Schoenhals M, Kassambara A, De Vos J, Hose D, Moreaux J, Klein B. Embryonic stem cell markers expression in cancers. Biochem Biophys Res Commun 383:157-162; 2009.
35. Semenenko VA, Molthen RC, Li C, Morrow NV, Li R, Ghosh SN, Medhora MM, Li XA. Irradiation of varying volumes of rat lung to same mean lung dose: a little to a lot or a lot to a little? Int J Radiat Oncol Biol Phys 71:838-847; 2008.
36. Shen ZY, Ye CQ, Wu DC. Effect of inhaled 239PuO2 on alveolar type II cells. Int J Radiat Biol 56:169 -178; 1989.
37. Talbot RJ, Moores SR. The development and interlobar distribution of plutonium-induced pulmonary fibrosis in mice. Radiat Res 103:135-148; 1985.
38. Taya A, Black A, Baker ST, Humphreys JA. Proliferation of mouse lung epithelial cells after inhalation exposure to 239PuO2. Radiat Res 136:366 -372; 1993.
39. Travis EL, Liao ZX, Tucker SL. Spatial heterogeneity of the volume effect for radiation pneumonitis in mouse lung. Int J Radiat Oncol Biol Phys 38:1045-1105; 1997.
40. Trosko JE. From adult stem cells to cancer stem cells Oct-4 gene, cell-cell communication and hormones during tumor promotion. Ann NY Acad Sci 1089:36 -58; 2006.
41. Trott KR, Herrmann T, Kasper M. Target cells in radiation pneumopathy. Int J Radiat Oncol Biol Phys 582:463- 469; 2004.
42. Tsoutsou PG, Koukourakis MI. Radiation pneumonitis and fibrosis: mechanisms underlying its pathogenesis and implications for future research. Int J Radiat Oncol Biol Phys 665:1281-1293; 2006.
43. Van der Meeren A, Tourdes F, Grémy O, Grillon G, Abram MC, Poncy JL, Griffiths N. Activation of alveolar macrophages following plutonium oxide inhalation in rats: involvement in the early inflammatory response. Radiat Res 170:591- 603; 2008.
44. Zeltner TB, Bertacchini M, Messerli A, Burri PH. Morphometric estimation of regional differences in the rat lung. Exp Lung Res 16:145-158; 1990.