Radiotoxicity of inhaled239PuO2 in dogs

Radiation Research

Volumn 170, Issue 6, 2008, Pages 736-757

  Muggenburg, Bruce A ^a   Guilmette, Raymond A ^a   Hahn, Fletcher F ^a   Diel, Joseph H ^a   Mauderly, Joe L ^a   Seilkop, Steven K ^b   Boecker, Bruce B ^a  

^a LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^b SKS Consulting Services   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLUTONIUM DIOXIDE PU 239; RADIOISOTOPE;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATROPHY; CANCER RISK; CONTROLLED STUDY; DOG; FEMALE; HEALTH HAZARD; LUNG ALVEOLUS CELL CARCINOMA; LUNG CARCINOGENESIS; LUNG FIBROSIS; LUNG TUMOR; LYMPHATIC SYSTEM DISEASE; LYMPHOCYTOPENIA; MALE; NONHUMAN; OSTEOARTHROPATHY; PARTICLE SIZE; PRIORITY JOURNAL; RADIATION EXPOSURE; RADIATION PNEUMONIA;

ABSORPTION; ANIMALS; DOGS; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; HEMATOLOGY; INHALATION EXPOSURE; LUNG NEOPLASMS; MALE; PARTICLE SIZE; PLUTONIUM; PULMONARY FIBROSIS; RADIATION DOSAGE; RADIATION PNEUMONITIS; RADIOMETRY; RISK ASSESSMENT; TISSUE DISTRIBUTION;

CANIS FAMILIARIS;

EID: 57149105942     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR1409.1     Document Type: Article

References (81)

1. J. N. Stannard, Radioactivity and Health: A History. Report DOE/RL/01830-T59, Pacific Northwest Laboratory, Richland, WA, 1988.
2. R. C. Thompson, Life-Span Effects of Ionizing Radiation in the Beagle Dog: A Summary Account of Research Funded by the U.S. Department of Energy and Its Predecessor Agencies. Report PNL-6822, Pacific Northwest Laboratory, Richland, WA, 1989.
3. M. P. Finkel and B. O. Biskis, Toxicity of plutonium in mice. Health Phys. 8, 565-579 (1962).
4. 239Pu in the dog. In Radiobiology of Plutonium (B. J. Stover and W. S. S. Jee, Eds.), pp. 75-86. The J. W. Press, Salt Lake City, UT, 1972.
5. 241Am. In Life-Span Radiation Effects Studies in Animals: What Can They Tell Us? (R. C. Thompson and J. A. Mahaffey, Eds.), pp. 268-285. CONF-830951, Office of Scientific and Technical Information, Springfield, VA, 1986.
6. M. E. Wrenn, G. N. Taylor, W. Stevens, C. W. Mays, W. S. S. Jee, R. D. Lloyd, D. R. Atherton, F. W. Bruenger, S. C. Miller and B. J. Stover, DOE life-span radiation effects studies in experimental animals at University of Utah Division of Radiobiology. In Life-Span Radiation Effects Studies in Animals: What Can They Tell Us? (R. C. Thompson and J. A. Mahaffey, Eds.), pp. 32-52. CONF-830951, Office of Scientific and Technical Information, Springfield, VA, 1986.
7. 239Pu as young adults. Health Phys. 64, 45-51 (1993).
8. 2. Radiat. Res. 111, 201-224 (1987).
9. 2 in rats. Radiat. Res. 68, 349-360 (1976).
10. Y. Oghiso, Y. Yamada, H. Iida and J. Inaba, Differential dose responses of pulmonary tumor types in the rat alter inhalation of plutonium dioxide aerosols. J. Radiat. Res. 39, 61-72 (1998).
11. 2. Int. J. Radiat. Biol. 40, 605-611 (1981).
12. 2. Int. J. Radiat. Biol. 43, 1-18 (1983).
13. R. C. Thompson, F. T. Cross, G. E. Dagle, J. F. Park and C. L. Sanders, DOE life-span radiation effects studies at Pacific Northwest Laboratory. In Life-Span Radiation Effects Studies in Animals: What Can They Tell Us? (R. C. Thompson and J. A. Mahaffey, Eds.), pp. 66-73. CONF-830951, Office of Scientific and Technical Information, Springfield, VA, 1986.
14. R. O. McClellan, B. B. Boecker, F. F. Hahn and B. A. Muggenburg, Lovelace ITRI studies on the toxicity of inhaled radionuclides in beagle dogs. In Life-Span Radiation Effects Studies in Animals: What Can They Tell Us? (R. C. Thompson and J. A. Mahaffey, Eds.), pp. 74-96. CONF-830951, Office of Scientific and Technical Information, Springfield, VA, 1986.
15. 4 in cynomolgus monkeys. Radiat. Res. 130, 79-87 (1992).
16. 2 in baboons. Health Phys. 27, 512-514 (1974).
17. G. L. Voelz and J. N. P. Lawrence, A 42-year medical follow-up of Manhattan project plutonium workers. Health Phys. 61, 181-190 (1991).
18. L. D. Wiggs, E. R. Johnson, C. A. Cox-DeVore and G. L. Voelz, Mortality through 1990 among white male workers at the Los Alamos National Laboratory: Considering exposures to plutonium and external ionizing radiation. Health Phys. 67, 577-588 (1994).
19. R. Z. Omar, J. A. Barber and P. G. Smith, Cancer mortality and morbidity among plutonium workers at the Sellafield plant of British Nuclear fuels. Br. J. Cancer 79, 1288-1301 (1999).
20. S. C. Brown, M. F. Schonbeck, D. McClure, A. E. Baron, W. C. Navidi, T. Byers and A. J. Ruttenber, Lung cancer and internal lung doses among plutonium workers at the Rocky Flats Plant: A case-control study. Am. J. Epidemiol. 160, 163-172 (2004).
21. S. Wing, D. Richardson, S. Wolf and G. Mihlan, Plutonium-related work and cause-specific mortality at the United States Department of Energy Hanford Site. Am. J. Ind. Med. 45, 153-164 (2004).
22. L. S. Newman, M. M. Mroz and A. J. Ruttenber, Lung fibrosis in plutonium workers. Radiat. Res. 164, 123-131 (2005).
23. N. D. Okladnikova, V. S. Pesternikova, M. V. Sumina and V. N. Doshchenko, Occupational diseases from radiation exposure at the first nuclear plant in the USSR. Sci. Total Environ. 142, 9-17 (1994).
24. Z. B. Tokarskaya, N. D. Okladnikova, Z. D. Belyaeva and E. G. Drozhko, Multifactorial analysis of lung cancer dose-response relationships for workers at the Mayak Nuclear Enterprise. Health Phys. 73, 899-905 (1997).
25. N. A. Koshurnikova, E. S. Gilbert, M. Sokolnikov, V. F. Khokhryakov, S. Miller, D. L. Preston, S. A. Romanov, N. S. Shilnikova, K. G. Suslova and V. V. Vostrotin, Bone cancers in Mayak workers. Radiat. Res. 154, 237-245 (2000).
26. E. S. Gilbert, N. A. Koshurnikova, M. Sokolnikov, V. F. Khokhryakov, S. Miller, D. L. Preston, S. A. Romanov, N. S. Shilnikova, K. G. Suslova and V. V. Vostrotin, Liver cancers in Mayak workers. Radiat. Res. 154, 246-252 (2000).
27. M. Kreisheimer, M. E. Sokolnikov, N. A. Koshurnikova, V. F. Khokhryakov, S. A. Romanov, N. S. Shilnikova, P. V. Okatenko, E. A. Nekolla and A. M. Kellerer, Lung cancer mortality among nuclear workers of the Mayak facilities in the former Soviet Union: an updated analysis considering smoking as the main confounding factor. Radiat. Environ. Biophys. 42, 129-135 (2003).
28. E. S. Gilbert, N. A. Koshurnikova, M. E. Sokolnikov, N. S. Shilnikova, D. L. Preston, E. Ron, P. V. Okatenko, V. F. Khokhryakov, E. K. Vasilenko and S. A. Romanov, Lung cancer in Mayak workers. Radiat. Res. 162, 505-516 (2004).
29. B. A. Muggenburg, R. A. Guilmette, J. A. Mewhinney, N. A. Gillett, J. L. Mauderly, W. C. Griffith, J. H. Diel, B. R. Scott, F. F. Hahn and B. B. Boecker, Toxicity of inhaled plutonium dioxide in beagle dogs. Radiat. Res. 145, 361-381 (1996).
30. A. R. Tamplin and T. B. Cochran, Radiation Standards for Hot Particles: A Report on the Inadequacy of Existing Radiation Protection Standards Related to Internal Exposure of Man to Insoluble Particles of Plutonium and Other Alpha-emitting Hot Particles. National Resources Defense Council, Washington, DC, 1974.
31. 2 in the beagle dog: Effect of particle size. Int. J. Radiat. Biol. 45, 563-581 (1984).
32. 2. In Radiation Risk Protection (A. Kaul, Ed.), pp. 384-387. IRPA, Berlin, 1984.
33. F. F. Hahn, B. A. Muggenburg, B. B. Boecker, R. G. Cuddihy, W. C. Griffith, R. A. Guilmette, R. O. McClellan and J. A. Mewhinney, Insights into radionuclide-induced lung cancer in people from lifespan studies in beagle dogs. In Life-Span Radiation Effects Studies in Animals: What Can They Tell Us? (R. C. Thompson and J. A. Mahaffey, Eds.), pp. 521-534. CONF-830951, Office of Scientific and Technical Information, Springfield, VA, 1986.
34. 2. Radiat. Res. 110, 199-218 (1987).
35. B. B. Boecker, F. F. Hahn, B. A. Muggenburg, R. A. Guilmette, W. C. Griffith and R. O. McClellan, The relative effectiveness of inhaled alpha- and beta-emitting radionuclides in producing cancer. Radiat. Prot. Practice 2, 1059-1062 (1988).
36. 2 aerosols: Status report. Radiat. Prot. Practice 2, 1063-1066 (1988).
37. B. A. Muggenburg, R. K. Wolff, J. L. Mauderly, M. M. Plaggmier, F. F. Hahn, R. A. Guilmette and R. F. Gerlach, Cardiopulmonary function of dogs with plutonium-induced chronic lung injury. Radiat. Res. 115, 314-324 (1988).
38. G. Kelly, P. R. Kerkof, A. L. Brooks and P. J. Haley, Oncogene activation in radiation-induced lung tumors. In Low Dose Radiation: Biological Bases of Risk Assessment (K. F. Baverstock and J. W. Stather, Eds.), pp. 286-295. Taylor & Francis, London, 1989.
39. G. Kelly, P. R. Kerkof and P. J. Haley, Receptors for growth factors are expressed in radiation-induced lung tumors. In Multilevel Health Effects Research: From Molecules to Man (J. F. Park and R. A. Pelroy, Eds.), pp. 181-188. Battelle Press, Columbus, OH, 1989.
40. B. A. Muggenburg, R. A. Guilmette, F. F. Hahn, W. C. Griffith, Jr., B. B. Boecker, J. H. Diel and R. O. McClellan, The effects of non-uniformity of alpha irradiation of the lung on biological effects. In Low Dose Radiation: Biological Bases of Risk Assessment (K. F. Baverstock and J. W. Stather, Eds.), pp. 305-311. Taylor & Francis, London, 1989.
41. N. A. Gillett, B. L. Stegelmeier, I-Y. Chang and G. Kelly, Expression of transforming growth factor receptor in plutonium-239 induced lung neoplasms in dogs: Investigations of autocrine mechanisms of growth. Radiat. Res. 126, 289-295 (1991).
42. 2 exposures in dogs: Persistent T lymphocyte dysfunction. Int. J. Radiat. Biol. 61, 123-133 (1992).
43. N. A. Gillett, B. L. Stegelmeier, G. Kelly, P. J. Haley and F. F. Hahn, Expression of epidermal growth factor receptor in plutonium-239-induced lung neoplasms in dogs. Vet. Pathol. 29, 425-449 (1992).
44. R. A. Guilmette and W. C. Griffith, The effect of isotope on the dosimetry of inhaled plutonium oxide. In Proceedings of the 8th International Congress of the International Radiation Protection Association, pp. 900-903. IRPA, Montreal, 1992.
45. 2 and beta-emitting radionuclides on the incidence of lung carcinomas in laboratory animals. In Proceedings of the 8th International Congress of the International Radiation Protection Association, pp. 916-919. IRPA, Montreal, 1992.
46. B. A. Muggenburg, F. F. Hahn, M. G. Ménache, R. A. Guilmette and B. B. Boecker, Comparative deterministic effects of inhaled, insoluble alpha- and beta-particle-emitting radionuclides in dogs. Radiat. Res. 152 (Suppl.), S23-S26 (1999).
47. F. F. Hahn, B. A. Muggenburg, R. A. Guilmette and B. B. Boecker, Comparative stochastic effects of inhaled alpha- and beta-particle-emitting radionuclides in beagle dogs. Radiat. Res. 152 (Suppl.), S19-S22 (1999).
48. 2 and evaluation of gamma emitting labels. Health Phys. 28, 655-667 (1975).
49. P. Kotrappa and M. E. Light, Design and performance of the Lovelace aerosol particle separator. Rev. Sci. Instrum. 43, 1106-1112 (1972).
50. B. B. Boecker, F. L. Aguilar and T. T. Mercer, A canine inhalation exposure apparatus utilizing a whole body plethysmograph. Health Phys. 10, 1077-1089 (1964).
51. T. T. Mercer, M. I. Tillery and G. J. Newton, A multistage, low flow rate cascade impactor. J. Aerosol Sci. 1, 9-15 (1970).
52. P. E. Morrow and T. T. Mercer, Point-to-plane electrostatic precipitator for particle size sampling. Am. Ind. Hyg. Assoc. 25, 8-14 (1964).
53. S. W. Bielfelt, A. J. Wilson, H. C. Redman, R. O. McClellan and L. S. Rosenblatt, A breeding program for the establishment and maintenance of a stable gene pool in a beagle dog colony to be utilized for long-term experiments. Am. J. Vet. Res. 30, 2221-2229 (1969).
54. R. W. Kirk, Ed., Current Veterinary Therapy. VII. Small Animal Practice. W. B. Saunders, Philadelphia, 1970.
55. R. F. Keough and G. J. Powers, Determination of plutonium in biological materials by extraction and liquid scintillation counting. Anal. Chem. 42, 419-421 (1970).
56. J. Motulsky and A. Christopoulos, Fitting Models to Biological Data Using Linear and Nonlinear Regression. A Practical Guide to Curve Fitting. GraphPad Software Inc., San Diego, CA, 2003. [available online at www.graphpad.com]
57. J. L. Mauderly, Influence of sex and age on the pulmonary function of the unanesthetized beagle dog. J. Gerontol. 29, 282-289 (1974).
58. J. L. Mauderly, A new technique for evaluating nitrogen wash-out efficiency. Am. J. Vet. Res. 38, 69-74 (1977).
59. 144Ce on cardiopulmonary function and histopathology of the dog. Radiat. Res. 84, 307-324 (1980).
60. C. Watson and G. Dagle, Atlas of Experimentally Induced Neoplasia in the Beagle Dog. Battelle Press, Columbia, OH, 1997.
61. International Histologic Classification of Tumors of Domestic Animals. Bull. WHO 50, 1-142 (1974).
62. International Histologic Classification of Tumors of Domestic Animals. Bull. WHO 53, 137-304 (1976).
63. 2. Radiat. Res. 150, 66-82 (1998).
64. J. J. Gart, D. Krewski, P. N. Lee, R. E. Tarone and J. Wahrendorf, Statistical Methods in Cancer Research: Volume III - The Design and Analysis of Long-Term Animal Experiments. Publication No. 79, International Agency for Research on Cancer, Lyon, 1986.
65. B. A. Muggenburg, F. F. Hahn and S. A. Benjamin, Cause of mortality in laboratory beagle colonies. In Pathobiology of the Aging Dog, Vol. 1 (U. Mohr, W. W. Carlton, D. L. Dungworth, S. A. Benjamin, C. C. Capen and F. F. Hahn, Eds.), pp. 25-33. International Life Sciences Institute, Iowa State University Press, Ames, 2001.
66. R. Peto, R. Gray, P. Brantom and P. Grasso, Dose and time relationships for tumor induction in the liver and esophagus of 4080 inbred rats by chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine. Cancer Res. 51, 6452-6469 (1991).
67. F. F. Hahn and G. E. Dagle, Non-neoplastic pulmonary lesions. In Pathobiology of the Aging Dog, Vol. 1 (U. Mohr, W. W. Carlton, D. L. Dungworth, S. A. Benjamin, C. C. Capen and F. F. Hahn, Eds.), pp. 57-68. International Life Sciences Institute, Iowa State University Press, Ames, 2001.
68. 2. In Radiation and the Lymphatic System (J. Ballou, Ed.), pp. 83-89. National Technical Information Service, Springfield, VA, 1976.
69. M. B. Snipes, B. A. Muggenburg and D. E. Bice, Translocation of particles from lung lobes or the peritoneal cavity to regional lymph nodes in beagle dogs. J. Toxicol. Environ. Health 11, 703-712 (1983).
70. R. E. Weller, R. L. Buschbom, J. F. Park, G. E. Dagle and H. A. Ragan, Hematological effects of inhaled plutonium dioxide in beagles. Radiat. Res. 143, 69-76 (1995).
71. A. G. Harmsen, B. A. Muggenburg, M. B. Snipes and D. E. Bice, The role of macrophages in particle translocation from lung to lymph nodes. Science 230, 1277-1280 (1985).
72. A. G. Harmsen, M. J. Mason, B. A. Muggenburg, N. A. Gillett, M. A. Jarpe and D. E. Bice, Migration of neutrophils from lung to tracheobronchial lymph node. J. Leukoc. Biol. 41, 95-103 (1987).
73. 2 in beagles. Radiat. Res. 148, 365-381 (1997).
74. F. F. Hahn, S. A. Romanov, R. A. Guilmette, A. P. Nifatov, J. A. Diel and Y. Zaytseva, Plutonium microdistribution in the lungs of Mayak workers. Radiat. Res. 161, 568-581 (2004).
75. 2. In Proceedings of the 3rd International Symposium on Radiation Protection: Advances in Theory and Practice, Vol. 1, pp. 370-375. Society for Radiological Protection, London, 1982.
76. 4 in beagle dogs. Radiat. Prot. Dosimetry 26, 173-176 (1989).
77. 2. Radiat. Res. 147, 598-612 (1997).
78. E. C. Anderson, L. M. Holland, J. R. Prine and D. M. Smith, Tumorigenic hazard of particulate alpha activity in Syrian hamster lungs. Radiat. Res. 78, 82-97 (1979).
79. M. W. Charles, A. J. Mill and P. J. Darley, Carcinogenic risk of hot-particle exposures. J. Radiol. Prot. 23, 5-28 (2003).
80. F. F. Hahn, B. A. Muggenburg and W. C. Griffith, Primary lung neoplasia in a beagle colony. Vet. Pathol. 33, 633-638 (1996).
81. J. N. Stannard, The concept of critical organ and radiation dose as applied to plutonium. Health Phys. 85, 264-274 (2003).