Comparative absorption parameters of Pu and Am from PuO2 and mixed oxide aerosols measured after in vitro dissolution test and inhalation in rats

International Journal of Radiation Biology

Volumn 80, Issue 10, 2004, Pages 777-785

  Rateau Matton, S ^a   Ansoborlo, E ^b   Hodgson, A ^c  

^a CEA DIF   (France)

^b CEA/DEN/DRCP/CETAMA   (France)

^c PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMERICIUM; PLUTONIUM;

ABSORPTION; AEROSOL; ARTICLE; CHEMICAL COMPOSITION; DISSOLUTION; INHALATION; NONHUMAN; PRIORITY JOURNAL; RADIATION EXPOSURE; RAT;

ABSORPTION; AEROSOLS; ANIMALS; DOSE FRACTIONATION; INHALATION; LUNG; METABOLIC CLEARANCE RATE; OXIDES; PLUTONIUM; RATS; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 12344265145     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/09553000400017978     Document Type: Article

References (36)

1. ANDRÉ, S., RATEAU, G., VAVASSEUR, C. and MÉTIVIER, H., 1989, Design of a new inhalation device for rodents and primates. Journal of aerosols science, 20, 647-656.
2. ANSOBORLO, E., CHALABREYSSE, J., HENGÉ-NAPOLI, M-H. and PUJOL, E., 1992, In vitro chemical and cellular tests applied to uranium trioxide with different hydratation states. Environmental Health Perspectives, 97, 139-143.
3. ANSOBORLO, E., GUILMETTE, R. A., HOOVER, M. D., CHAZEL, V., HOUPERT, P. and HENGÉ-NAPOLI, M. H., 1998, Application of in vitro dissolution tests to different uranium compounds and comparison with in vivo data. Radiation Protection Dosimetry, 79, 33-37.
4. ANSOBORLO, E., CHAZEL, V. and HENGÉ-NAPOLI, M. H., 2002, Determination of the physical and chemical properties, biokinetics and dose coefficients of uranium compounds handled during nuclear fuel fabrication in France. Health Physics, 82, 3, 279-289.
5. Edited by Fisher, D. R. Technical Information Center, U.S Department of Energy.
6. BAILEY, M. R., KREYLING, W. G., ANDRE, S., BATCHELOR, A., COLLIER, C. G., DROSSELMEYER, E., FERRON, G. A., FOSTER, P., HAIDER, B., HODGSON, A., MASSE, R., METIVIER, H., MORGAN, A., MÜLLER, H.-L., PATRICK, G., PEARMAN, I., PICKERING, S., RAMDSEN, D., STIRLING, C. and TALBOT, R. J., 1989, An interspecies comparison of the lung clearance of inhaled monodisperse cobalt oxide particles Part I: objectives and summary of results. Journal of Aerosol Sciences, 20(2), 169-188.
7. BAILEY, M. R., GUILMETTE, R. A., JARVIS, N. S. and ROY, M., 1998, Practical application of the new ICRP human respiratory tract model. Radiation Protection Dosimetry, 79, 17-22.
8. BAILEY, M. R., ANSOBORLO, E., CAMNER, P., CHAZEL, V., FRITSCH, P., HODGSON, A., KREYLING, W. G., LE GALL, B., NEWTON, D., PAQUET, F., STRADLING, N. and TAYLOR, D. M., 2003, RBDATA-EULEP: Providing information to improve internal dosimetry. Radiation Protection Dosimetry, 105, 633-636.
9. BIRCHALL, A., BAILEY, M. and JARVIS, N., 1995, Application of the new ICRP respiratory tract model to inhaled plutonium nitrate using experimental biokinetic data. In: Proceedings of an International Conference On Radiation Dose Management in the Nuclear Industry, Windermere, UK, 9-11 October. London: British Nuclear Energy Society, pp. 216-223.
10. CARBAUGH, E. H. and LA BONE, T. R., 2003, Two case studies of higly insoluble plutonium inhalation with implications for bioassay. Radiation Protection Dosimetry, 105, 4, 133-138.
11. 8 specific surface area on in vitro dissolution, biokinetics and dose coefficients. Radiation Protection Dosimetry, 79, 39-42.
12. EIDSON, A. F., 1980, Comparative of physical chemical properties of powders and respirable aerosols of industrial mixed uranium and plutonium oxide fuels. Annual Progress Report, Lovelace Biomedical and Environnemental Research Institute. Prepared for US Nuclear Regulatory Commission, NUREG/CR-1736.
13. EIDSON, A. F. and MEWHINNEY, J. A., 1981, In vitro dissolution of respirable aerosols of industrial uranium and plutonium mixed-oxide nuclear fuels. Annual Progress Report, Lovelace Biomedical and Environment Research Institute. Prepared for US Nuclear Regulatory Commision, NUREG/CR-2171, LMF-79.
14. EIDSON, A. F. and MEWHINNEY, J. A., 1983, In vitro dissolution of respirable aerosols of industrial uranium and plutonium mixed-oxide nuclear fuel. Health Physics, 45, 1023-1037.
15. FERIN, J., 1975, Lung clearance of particles. In: E. F. Aharonson, A. Ben-David and M. A. Klingberg (eds), Air pollution and the lung (New York: John Wiley & sons). pp. 64-78.
16. HORWITZ, E. P., DIETZ, M. L., NELSON, D. M., LAROSA, J. J. and FAIRMAN, W. D., 1990, Concentration and separation of actinides from urines using a supported bifunctionnal organo phosphorus extractant. Analytica Chimica Acta, 238, 263-271.
17. INTERNATIONAL COMMISSION ON RADIOLOGICAL PROTECTION, 1994a, Human respiratory tract model for radiological protection, Ann 24 (1-3) Publication 66, (Oxford: Elsevier Science Ltd.).
18. INTERNATIONAL COMMISSION ON RADIOLOGICAL PROTECTION, 1994b, Human respiratory tract model for radiological protection, Ann 25 (3-4) Publication 71, (Oxford: Elsevier Science Ltd.).
19. INTERNATIONAL COMMISSION ON RADIOLOGICAL PROTECTION, 2002, Guide for the practical Application of the ICRP Human Respiratory Tract Model, Supporting Guidance 3: 32, 1-2. (Oxford: Elsevier Science Ltd.).
20. JAMES, A. C. and AL, 1978, Lung clearance and translocation in rats and hamsters of inhaled dust containing mixed actinide oxide from a fuel fabrication plants. NRPB/ R&D2, 5-64.
21. JARVIS, N. S., BIRCHALL, A. and JAMES, A. C. et al., 1996, LUDEP 2.0. Personal computer program for calculating internal doses using the ICRP the ICRP Publication 66 respiratory tract model. NRPB-SR287, National Radiological Protection Board, Chilton, UK.
22. KREYLING, W. G., COX, C., FERRON, G. A. and OBERDOSTER, G., 1993, Lung clearance in Long-Evans rats after inhalation of porous, monodisperse cobalt oxide particles. Experimental lung Research, 19, 445-467.
23. LATAILIADE, G., VERRY, M. and RATEAU, G., 1995, Translocation of Pu from rat and monkey lung after inhalation of industrial plutonium oxide and mixed U and Pu oxide. International Journal of Radiation Biology, 67, 373-380.
24. MASSIOT, P., LEPRINCE, B., LIZON, C., LE FOLL, L., L'HULLIER, I., RATEAU, G. and FRITSCH, P., 1998a, Physico-chemical characterisation of inhalable MOX particles according to industrial process. Radiation Protection Dosimetry, 79, 43-48.
25. MASSIOT, P., LEPRINCE, B., LIZON, C., RATEAU, G., GRILLON, G., RICHTER, K. and FRITSCH, P., 1998b, Chemical composition of inhalable MOX powders prepared according to a SOLGEL process: an energy dispersive X-ray analysis of individual particles. Journal of Alloys and Compounds, 271-273, 38-41.
26. MERCER, T. T., 1967, On the role of particle size in the dissolution of lung burdens. Health Physics, 13, 1211-1221.
27. MERCER, T. T., TILLERY, M. I. and NEWTON, G. J., 1970, A multi stage flow rate cascade impactor. Journal of Aerosol Sciences, 1, 9-15.
28. MEWHINNEY, J. A. and EIDSON, A. F., 1987, Effect of wet and dry cycles on dissolution of relatively insoluble particles containing Pu. Health physics, 53, 377-384.
29. MIGLIO, J. J., MUGGENBURG, B. A. and BROOKS, A. L., 1977, A rapid method for determining the relative solubility of plutonium aerosol. Health Physics, 33, 449-457.
30. MORGAN, A., EVANS, J. C. and HOLMES, A., 1977, Deposition and clearance of inhaled fibrous minerals in the rat. Studies using radioactive tracer techniques. Inhaled Particles IV Part, 1, 259-274.
31. PRESS, W. H., TEUKOLSKY, S. A., VETTERLING, W. T. and FLANNERY, B. P., 1992, Numerical recipes in FORTRAN. (Cambridge: Cambridge University Press).
32. RAMOUNET-LE GALL, B., RATEAU, G., ABRAM, M.-C., GRILLON, G., ANSOBORLO, E., BERARD, P., DELFORGE, J. and FRITSCH, P., 2003, In vivo measurement of Pu dissolution parameters of MOX aerosols and related uncertainties in the values of the dose per unit of intake. Radiation Protection Dosimetry, 105, 1-4, 153-156.
33. 2 in rat. International Journal of Radiation Biology, 76(2), 215-222.
34. 2 calcined at 1150°C and 400°C. Journal of Radiation Research, 40, 197-204.
35. STANLEY, J. A., EIDSON, A. F. and MEWHINNEY, J. A., 1982, Distribution, retention and dosimetry of plutonium and americium in the rat, dog and monkey after inhalation of an industrial-mixed uranium and plutonium oxide aerosol. Health Physics, 43, 521-530.
36. STRINGER, B., RUSSELL, P. J., DAVIES, B. W. and DANSO, K. A., 1984, Basic aspects of gel-precipitation route to nuclear fuel. Radiochimica acta, 36, 31-36.