Work in progress report - Thoracic oncologic OCT4 expression in human non-small cell lung cancer: implications for therapeutic intervention

Interactive Cardiovascular and Thoracic Surgery

Volumn 8, Issue 4, 2009, Pages 393-397

  Karoubi, Golnaz ^a   Gugger, Mathias ^a   Schmid, Ralph ^a   Dutly, André ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Adenocarcinoma; Bronchioloalveolar carcinoma; Cancer stem cells; OCT4

Indexed keywords

OCTAMER TRANSCRIPTION FACTOR 4; CD133 ANTIGEN; MESSENGER RNA; POU5F1 PROTEIN, HUMAN;

CARCINOGENESIS; CELL GROWTH; CELL STRUCTURE; CONFERENCE PAPER; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG ALVEOLUS CELL CARCINOMA; LUNG CARCINOMA; LUNG NON SMALL CELL CANCER; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TUMOR BIOPSY; CANCER STAGING; CANCER SURGERY; HISTOPATHOLOGY; PLEURA EFFUSION; ADENOCARCINOMA; ARTICLE; BIOPSY; CANCER STEM CELL; COMPARATIVE STUDY; GENETICS; LUNG TUMOR; METABOLISM; PATHOLOGY; POLYMERASE CHAIN REACTION; TUMOR CELL CULTURE;

ADENOCARCINOMA; ADENOCARCINOMA, BRONCHIOLO-ALVEOLAR; BIOPSY; CARCINOMA, NON-SMALL-CELL LUNG; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; NEOPLASTIC STEM CELLS; OCTAMER TRANSCRIPTION FACTOR-3; POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 65249108175     PISSN: 15699293     EISSN: None     Source Type: Journal    
DOI: 10.1510/icvts.2008.193995     Document Type: Conference Paper

References (15)

1. Janssen-Heijnen ML, Coebergh JW. The changing epidemiology of lung cancer in Europe. Lung Cancer 2003;41:245-258.
2. Gómez-Román JJ, Del Valle CE, Zarrabeitia MT, Martínez JC, Goñi FZ, Lera RM, Cuevas J, Val-Bernal JF. Recurrence of bronchioloalveolar carcinoma in donor lung after lung transplantation: microsatellite analysis demonstrates a recipient origin. Pathol Int 2005;55:580-584.
3. Minna JD, Roth JA, Gazdar AF. Focus on lung cancer. Cancer Cell 2002;49-52.
4. Chen YC, Hsu HS, Chen YW, Tsai TH, How CK, Wang CY, Hung SC, Chang YL, Tsai ML, Lee YY, Ku HH, Chiou SH. Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells. PLoS ONE 2008;3:e2637.
5. Trosko JE. From adult stem cells to cancer stem cells: Oct-4 Gene, cell-cell communication, and hormones during tumor promotion. Ann N Y Acad Sci 2006;1089:36-58.
6. Hochedlinger K, Yamada Y, Beard C, Jaenisch R. Ectopic expression of OCT-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell 2005;121:465-477.
7. Sung MT, Jones TD, Beck SD, Foster RS, Cheng L. OCT4 is superior to CD30 in the diagnosis of metastatic embryonal carcinomas after chemotherapy. Hum Pathol 2006;37:662-667.
8. Gidekel S, Pizov G, Bergman Y, Pikarsky E. Oct-3y4 is a dose-dependent oncogenic fate determinant. Cancer Cell 2003;4:361-370.
9. Suo G, Han J, Wang X, Zhang J, Zhao Y, Zhao Y, Dai J. Oct4 pseudogenes are transcribed in cancers. Biochem Biophys Res Commun 2005; 337:1047-1051.
10. Hu T, Liu S, Breiter DR, Wang F, Tang Y, Sun S. Octamer 4 small interfering RNA results in cancer stem cell-like cell apoptosis. Cancer Res 2008;68:6533-6540.
11. Raz DJ, He B, Rosell R, Jablons DM. Current concepts in bronchioloalveolar carcinoma biology. Clin Cancer Res 2006;12:3698-3704.
12. Carney DN, Gazdar AF, Bunn PA Jr, Guccion JG. Demonstration of the stem cell nature of clonogenic tumor cells from lung cancer patients. Stem Cells 1982;1:149-164.
13. Loebinger MR, Giangreco A, Groot KR, Prichard L, Allen K, Simpson C, Bazley L, Navani N, Tibrewal S, Davies D, Janes SM. Squamous cell cancers contain a side population of stem-like cells that are made chemosensitive by ABC transporter blockade. Br J Cancer 2008;98:380- 387.
14. Ho MM, Ng AV, Lam S, Hung JY. Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells. Cancer Res 2007;67:4827-4833.
15. Tang DG, Patrawala LL, Calhoun T, Bhatia B, Choy G, Schneider- Broussard R, Jeter C. Prostate cancer stemyprogenitor cells: identification, characterization, and implications. Molecular Carcinogenesis 2007;46:1-14.