Can lineage-specific markers be identified to characterize mesenchyme-derived cell populations in the human airways?

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 299, Issue 2, 2010, Pages

  Singh, Shailendra R ^a   Billington, Charlotte K ^a   Sayers, Ian ^a   Hall, Ian P ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

smooth muscle actin; Airway fibroblasts; Airway myofibroblasts; Airway smooth muscle cells

Indexed keywords

ALDO KETO REDUCTASE 1C3; ALPHA SMOOTH MUSCLE ACTIN; ALPHA1 INTEGRIN; ALPHA2 INTEGRIN; ALPHA8 INTEGRIN; BIOLOGICAL MARKER; CALDESMON; CATHEPSIN K; LYMPHOCYTE ANTIGEN; OXIDOREDUCTASE; THROMBOXANE SYNTHASE; UNCLASSIFIED DRUG;

AIRWAY; ARTICLE; BREATHING MUSCLE; CELL POPULATION; CELL TYPE; CONTROLLED STUDY; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MESENCHYME CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER;

3-HYDROXYSTEROID DEHYDROGENASES; ACTINS; BIOLOGICAL MARKERS; BRONCHI; CALMODULIN-BINDING PROTEINS; CATHEPSIN K; CELL LINEAGE; CELLS, CULTURED; CULTURE MEDIA, SERUM-FREE; FIBROBLASTS; FLOW CYTOMETRY; HUMANS; HYDROXYPROSTAGLANDIN DEHYDROGENASES; IMMUNOHISTOCHEMISTRY; INTEGRIN ALPHA CHAINS; MALE; MESENCHYMAL STEM CELLS; MYOCYTES, SMOOTH MUSCLE; THROMBOXANE-A SYNTHASE;

EID: 77955595938     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00311.2009     Document Type: Article

References (56)

1. Albelda SM, Daise M, Levine EM, Buck CA. Identification and characterization of cell-substratum adhesion receptors on cultured human endothelial cells. J Clin Invest 83: 1992-2002, 1989.
2. Ammit AJ, Armour CL, Black JL. Smooth-muscle myosin light-chain kinase content is increased in human sensitized airways. Am J Respir Crit Care Med 161: 257-263, 2000.
3. Belkin VM, Belkin AM, Koteliansky VE. Human smooth muscle VLA-1 integrin: purification, substrate specificity, localization in aorta, and expression during development. J Cell Biol 111: 2159-2170, 1990.
4. Bell E, Ivarsson B, Merrill C. Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro. Proc Natl Acad Sci USA 76: 1274-1278, 1979
5. Boero S, Sabatini F, Silvestri M, Petecchia L, Nachira A, Pezzolo A, Scarso L, Rossi GA. Modulation of human lung fibroblast functions by ciclesonide: evidence for its conversion into the active metabolite desisobutyryl-ciclesonide. Immunol Lett 112: 39-46, 2007.
6. Brody JP, Williams BA, Wold BJ, Quake SR. Significance and statistical errors in the analysis of DNA microarray data. Proc Natl Acad Sci USA 99: 12975-12978, 2002.
7. Browning CL, Culberson DE, Aragon IV, Fillmore RA, Croissant JD, Schwartz RJ, Zimmer WE. The developmentally regulated expression of serum response factor plays a key role in the control of smooth muscle-specific genes. Dev Biol 194: 18-37, 1998.
8. Buhling F, Wille A, Rocken C, Wiesner O, Baier A, Meinecke I, Welte T, Pap T. Altered expression of membrane-bound and soluble CD95/Fas contributes to the resistance of fibrotic lung fibroblasts to FasL induced apoptosis. Respir Res 6: 37, 2005.
9. Cao D, Wang Z, Zhang CL, Oh J, Xing W, Li S, Richardson JA, Wang DZ, Olson EN. Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Mol Cell Biol 25: 364-376, 2005.
10. Carson JA, Culberson DE, Thompson RW, Fillmore RA, Zimmer W. Smooth muscle gamma-actin promoter regulation by RhoA and serum response factor signaling. Biochim Biophys Acta 1628: 133-139, 2003.
11. Chamley-Campbell J, Campbell GR, Ross R. The smooth muscle cell in culture. Physiol Rev 59: 1-61, 1979.
12. Daykin K, Widdop S, Hall IP. Control of histamine induced inositol phospholipid hydrolysis in cultured human tracheal smooth muscle cells. Eur J Pharmacol 246: 135-140, 1993.
13. Durand-Arczynska W, Marmy N, Durand J. Caldesmon, calponin and alpha-smooth muscle actin expression in subcultured smooth muscle cells from human airways. Histochemistry 100: 465-471, 1993.
14. Ehrlich H, Wyler DJ. Fibroblast contraction of collagen lattices in vitro: inhibition by chronic inflammatory cell mediators. J Cell Physiol 116: 345-351, 1983.
15. Esterre P, Melin M, Serrar M, Grimaud JA. New specific markers of human and mouse fibroblasts. Cell Mol Biol 38: 297-301, 1992.
16. Fatigati V, Murphy RA. Actin and tropomyosin variants in smooth muscles. Dependence on tissue type. J Biol Chem 259: 14383-14388, 1984.
17. Freyer AM, Johnson SR, Hall IP. Effects of growth factors and extracellular matrix on survival of human airway smooth muscle cells. Am J Respir Cell Mol Biol 25: 569-576, 2001.
18. Gabbiani G. The biology of the myofibroblast. Kidney Int 41: 530-532, 1992.
19. Hackett TL, Shaheen F, Johnson A, Wadsworth S, Pechkovsky DV, Jacoby DB, Kicic A, Stick SM, Knight DA. Characterization of side population cells from human airway epithelium. Stem Cells 26: 2576-2585, 2008.
20. Halayko AJ, Stephens NL. Potential role for phenotypic modulation of bronchial smooth muscle cells in chronic asthma. Can J Physiol Pharmacol 72: 1448-1457, 1994.
21. Halayko AJ, Salari H, Ma X, Stephens NL. Markers of airway smooth muscle cell phenotype. Am J Physiol Lung Cell Mol Physiol 270: L1040-L1051, 1996. (Pubitemid 26299672)
22. Halayko AJ, Camoretti-Mercado B, Forsythe SM, Vieira JE, Mitchell RW, Wylam ME, Hershenson MB, Solway J. Divergent differentiation paths in airway smooth muscle culture: induction of functionally contractile myocytes. Am J Physiol Lung Cell Mol Physiol 276: L197-L206, 1999.
23. Halayko AJ, Solway J. Molecular mechanisms of phenotypic plasticity in smooth muscle cells. J Appl Physiol 90: 358-368, 2001.
24. Hall IP, Kotlikoff M. Use of cultured airway myocytes for study of airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 268: L1-L11, 1995.
25. Hall IP. Second messengers, ion channels and pharmacology of airway smooth muscle. Eur Respir J 15: 1120-1127, 2000.
26. Hashimoto S, Gon Y, Takeshita I, Matsumoto K, Maruoka S, Horie T. Transforming growth factor-beta1 induces phenotypic modulation of human lung fibroblasts to myofibroblast through a c-Jun-NH2-terminal kinase-dependent pathway. Am J Respir Crit Care Med 163: 152-157, 2001.
27. Hirst SJ. Airway smooth muscle cell culture: application to studies of airway wall remodelling and phenotype plasticity in asthma. Eur Respir J 9: 808-820, 1996.
28. Jacobs JP, Jones CM, Baille JP. Characteristics of a human diploid cell designated MRC5. Nature 227: 168-170, 1970.
29. Katzenstein AL, Myers JL. Idiopathic pulmonary fibrosis. Clinical relevance of pathologic classification. Am J Respir Crit Care Med 157: 1301-1315, 1998.
30. Kicic A, Sutanto EN, Stevens PT, Knight DA, Stick SM. Intrinsic biochemical and functional differences in bronchial epithelial cells of children with asthma. Am J Respir Crit Care Med 174: 1110-1118, 2006.
31. Kirchhofer D, Languino LR, Ruoslahti E, Pierschbacher MD. Alpha 2 beta 1 integrins from different cell types show different binding specificities. J Biol Chem 265: 615-618, 1990.
32. Kuhn C, McDonald JA. The roles of the myofibroblast in idiopathic pulmonary fibrosis. Ultrastructural and immunohistochemical features of sites of active extracellular matrix synthesis. Am J Pathol 138: 1257-1265, 1991.
33. Kuo KH, Herrera AM, Seow CY. Ultrastructure of airway smooth muscle. Respir Physiol Neurobiol 137: 197-208, 2003.
34. Lecaille F, Brömme D, Lalmanach G. Biochemical properties and regulation of cathepsin K activity. Biochimie 90: 208-226, 2008.
35. Liu B, Freyer AM, Hall IP. Bradykinin activates calcium-dependent potassium channels in cultured human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 292: L898-L907, 2007.
36. T) method. Methods 25: 402-408, 2001.
37. Miano JM. Serum response factor: toggling between disparate programs of gene expression. J Mol Cell Cardiol 35: 577-593, 2003.
38. Mitchell JJ, Reynolds SE, Leslie KO, Low RB, Woodcock-Mitchell J. Smooth muscle cell markers in developing rat lung. Am J Respir Cell Mol Biol 3: 515-523, 1990.
39. Nelander S, Mostad P, Lindahl P. Prediction of cell type-specific gene modules: identification and initial characterization of a core set of smooth muscle-specific genes. Genome Res 8: 1838-1854, 2003.
40. Nüsing R, Lesch R, Ullrich V. Immunohistochemical localization of thromboxane synthase in human tissues. Eicosanoids 3: 53-58, 1990.
41. Owens GK, Kumar MS, Wamhoff BR. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev 84: 767-801, 2004.
42. Parekh A, Long RA, Iannone EC, Chancellor MB, Sacks MS. Assessing the effects of transforming growth factor-beta1 on bladder smooth muscle cell phenotype. I. Modulation of in vitro contractility. J Urol 182: 1210-1215, 2009.
43. Ramirez AM, Shen Z, Ritzenthaler JD, Roman J. Myofibroblast transdifferentiation in obliterative bronchiolitis: TGF-beta signaling through smad3-dependent and -independent pathways. Am J Transplant 6: 2080-2088, 2006.
44. Rùnnov-Jessen L, Celis JE, Van Deurs B, Petersen OW. A fibroblast-associated antigen: characterization in fibroblasts and immunoreactivity in smooth muscle differentiated stromal cells. J Histochem Cytochem 40: 475-486, 1992.
45. Singh SR, Billington CK, Hall IP. Clonal expansion and characterization of human airway myocytes from early passage cultures (Abstract). Am J Respir Crit Care Med 177: A495, 2008.
46. Skalli O, Schürch W, Seemayer T, Lagacé R, Montandon D, Pittet B, Gabbiani G. Myofibroblasts from diverse pathologic settings are heterogeneous in their content of actin isoforms and intermediate filament proteins. Lab Invest 60: 275-285, 1989.
47. ++-dependent adhesion of platelets to collagen. J Cell Biol 108: 1917-1924, 1989.
48. Tom-Moy M, Madison JM, Jones CA, de Lanerolle P, Brown JK. Morphologic characterization of cultured smooth muscle cells isolated from the tracheas of adult dogs. Anat Rec 218: 313-328, 1987.
49. Tran T, Ens-Blackie K, Rector ES, Stelmack GL, McNeill KD, Tarone G, Gerthoffer WT, Unruh H, Halayko AJ. Laminin-binding integrin alpha7 is required for contractile phenotype expression by human airway myocytes. Am J Respir Cell Mol Biol 37: 668-680, 2007.
50. Vandekerckhove J, Weber K. Actin typing on total cellular extracts: a highly sensitive protein-chemical procedure able to distinguish different actins. Eur J Biochem 113: 595-603, 1981.
51. Wenzel SE, Balzar S. Myofibroblast or smooth muscle: do in vitro systems adequately replicate tissue smooth muscle? Am J Respir Crit Care Med 174: 364-365, 2006.
52. 1 modulates myofibroblastic phenotype of rat palatal fibroblasts in vitro. Exp Cell Res 231: 328-336, 1997.
53. Yoshida T, Owens GK. Molecular determinants of vascular smooth muscle cell diversity. Circ Res 96: 280-291, 2005.
54. Zhang K, Rekhter MD, Gordon D, Phan SH. Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohistochemical and in situ hybridization study. Am J Pathol 145: 114-125, 1994. (Pubitemid 24217490)
55. Zhang S, Howarth PH, Roche WR. Cytokine production by cell cultures from bronchial subepithelial myofibroblasts. J Pathol 180: 95-101, 1996. (Pubitemid 26348899)
56. Zhou Y, Hagood JS, Murphy-Ullrich JE. Thy-1 expression regulates the ability of rat lung fibroblasts to activate transforming growth factor-beta in response to fibrogenic stimuli. Am J Pathol 165: 659-669, 2004.