Anticancer activity of a cyclooxygenase inhibitor, CX9051, in human prostate cancer cells: The roles of NF-κB and crosstalk between the extrinsic and intrinsic apoptotic pathways

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 382, Issue 2, 2010, Pages 159-169

  Huang, Chiung Hua ^a   Guh, Jih Hwa ^a   Chen, Grace Shiahuy ^a,b   Lu, Pin Hsuan ^a   Chern, Ji Wang ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b PROVIDENCE UNIVERSITY   (Taiwan)

Author keywords

Cyclooxygenase 2; Extrinsic apoptotic pathway; Mitochondria mediated apoptosis; NF B; Tumor necrosis factor related apoptosis inducing ligand

Indexed keywords

3 (4 BROMOPHENYL) 6 NITROBENZO[1.3.2]DITHIAZOLIUM YLIDE 1,1 DIOXIDE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CX 9051; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROSTAGLANDIN SYNTHASE INHIBITOR; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOCHEMISTRY; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL PROLIFERATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE TRANSLOCATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MITOCHONDRION; MOLECULAR INTERACTION; PROSTATE CANCER; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOTHIAZOLES; BLOTTING, WESTERN; CASPASES; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELL NUCLEUS; CELL PROLIFERATION; CYCLIC S-OXIDES; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; IN SITU NICK-END LABELING; MALE; NF-KAPPA B; PROSTATIC NEOPLASMS; RECEPTORS, DEATH DOMAIN; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 77955556639     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-010-0528-3     Document Type: Article

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