Expression of Tn and sialyl-Tn antigens in endometrial cancer: Its relationship with tumor-produced cyclooxygenase-2, tumor-infiltrated lymphocytes and patient prognosis

Anticancer Research

Volumn 26, Issue 6 A, 2006, Pages 4047-4053

  Ohno, Satoshi ^a   Ohno, Yumiko ^a   Nakada, Hiroshi ^b   Suzuki, Nobutaka ^a   Soma, Gen Ichiro ^c,d   Inoue, Masaki ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b KYOTO SANGYO UNIVERSITY   (Japan)

^c TOKUSHIMA BUNRI UNIVERSITY   (Japan)

^d TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

CD8+ T cells; Cyclooxygenase 2; Endometrial cancer; Mucin; Prognosis; Sialyl Tn antigen; Tn antigen

Indexed keywords

CYCLOOXYGENASE 2; MUCIN; SIALYL TN ANTIGEN; TN ANTIGEN; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CANCER SURVIVAL; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CONTROLLED STUDY; ENDOMETRIUM CANCER; ENZYME INDUCTION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; TUMOR ASSOCIATED LEUKOCYTE;

ADULT; AGED; ANTIGENS, CD8; ANTIGENS, TUMOR-ASSOCIATED, CARBOHYDRATE; CD8-POSITIVE T-LYMPHOCYTES; CYCLOOXYGENASE 2; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; LYMPHOCYTES, TUMOR-INFILTRATING; MIDDLE AGED; PROGNOSIS;

EID: 33845924961     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Kim YS, Gum J Jr and Brockhausen I: Mucin glycoproteins in neoplasia. Glycoconj J 13: 693-707, 1996.
2. Ravn V, Mandel U, Svenstrup B and Dabelsteen E: Simple mucin-type carbohydrates in normal and malignant human endometrium. Int J Gynecol Pathol 14: 158-166, 1995.
3. Semczuk A, Paszkowska A, Miturski R, Skomra D, Cybulski M, Jakowicki JA and Berbec H: Sialosyl-Tn expression in normal and pathological conditions of human endometrium. An immunohistochemical study. Pathol Res Pract 198: 589-595, 2002.
4. Inaba T, Sano H, Kawahito Y, Hla T, Akita K, Toda M, Yamashina I, Inoue M and Nakada H: Induction of cyclooxygenase-2 in monocyte/macrophage by mucins secreted from colon cancer cells. Proc Natl Acad Sci USA 100: 2736-2741, 2003.
5. Ohno S, Ohno Y, Suzuki N, Inagawa H, Kohchi C, Soma G and Inoue M: Multiple roles of cyclooxygenase-2 in endometrial cancer. Anticancer Res 25: 3679-3687, 2005.
6. Ohno Y, Ohno S, Suzuki N, Kamei T, Inagawa H, Soma G and Inoue M: Role of cyclooxygenase-2 in immunomodulation and prognosis of endometrial carcinoma. Int J Cancer 114: 696-701, 2005.
7. van de Wiel-van Kemenade E, Ligtenberg MJL, de Boer AJ, Buijs F, Vos HL, Melief CJM, Hilkens J and Figdor CG: Episialin (MUC1) inhibits cytotoxic lymphocyte-target cell interaction. J Immunol 151: 767-776, 1993.
8. Agrawal B, Krantz MJ, Reddish MA and Longenecker BM: Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2. Nat Med 4: 43-49, 1998.
9. Monti P, Leone BE, Zerbi A, Balzano G, Cainarca S, Sordi V, Pontillo M, Mercalli A, Di Carlo V, Allavena P and Piemonti L: Tumor-derived MUC1 mucins interact with differentiating monocytes and induce IL-10highIL-12low regulatory dendritic cell. J Immunol 172: 7341-7349, 2004.
10. Carlos CA, Dong HF, Howard OM, Oppenheim JJ, Hanisch FG and Finn OJ: Human tumor antigen MUC1 is chemotactic for immature dendritic cells and elicits maturation but does not promote Th1 type immunity. J Immunol 175: 1628-1635, 2005.
11. Ohshio G, Imamura T, Imamura M, Yamabe H, Sakahara H, Nakada H and Yamashina I: Distribution of Tn antigen recognized by an anti-Tn monoclonal antibody (MLS128) in normal and malignant tissues of the digestive tract. J Cancer Res Clin Oncol 121: 247-252, 1995.
12. Ohshio G, Yoshioka H, Manabe T, Sakahara H, Yamabe H, Imamura M, Inoue M, Tanaka N, Nakada H and Yamashina I: Expression of sialosyl-Tn antigen (monoclonal antibody MLS102 reactive) in normal tissues and malignant tumors of the digestive tract. J Cancer Res Clin Oncol 120: 325-330, 1994.
13. Jang TJ and Cho MY: Cyclooxygenase-2 expression and cell proliferation are increased in MUC2-positive area of columnar-lined esophagus. Pathol Int 55: 546-549, 2005.
14. Kim HJ, Lee SK, Kim MH, Seo DW and Min YI: Cyclooxygenase-2 mediates mucin secretion from epithelial cells of lipopolysaccharide-treated canine gallbladder. Dig Dis Sci 48: 726-732, 2003.
15. Belley A and Chadee K: Prostaglandin E(2) stimulates rat and human colonic mucin exocytosis via the EP(4) receptor. Gastroenterology 117: 1352-1362, 1999.
16. Kim YD, Kwon EJ, Park DW, Song SY, Yoon SK and Baek SH: Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells. Mol Pharmacol 62: 1112-1118, 2002.
17. Itzkowitz SH, Bloom EJ, Kokal WA, Modin G, Hakomori S and Kim YS: Sialosyl-Tn. A novel mucin antigen associated with prognosis in colorectal cancer patients. Cancer 66: 1960-1966, 1990.
18. Victorzon M, Nordling S, Nilsson O, Roberts PJ and Haglund C: Sialyl Tn antigen is an independent predictor of outcome in patients with gastric cancer. Int J Cancer 65: 295-300, 1996.
19. Ghazizadeh M, Ogawa H, Sasaki Y, Araki T and Aihara K: Mucin carbohydrate antigens (T, Tn, and sialyl-Tn) in human ovarian carcinomas: relationship with histopathology and prognosis. Hum Pathol 28: 960-966, 1997.
20. Flucke U, Zirbes TK, Schroder W, Monig SP, Koch V, Schmitz K, Thiele J, Dienes HP, Holscher AH and Baldus SE: Expression of mucin-associated carbohydrate core antigens in esophageal squamous cell carcinomas. Anticancer Res 21: 2189-2194, 2001.
21. Leivonen M, Nordling S, Lundin J, von Boguslawski K and Haglund C: STn and prognosis in breast cancer. Oncology 61: 299-305, 2001.
22. Bresalier RS, Ho SB, Schoeppner HL, Kim YS, Sleisenger MH, Brodt P and Byrd JC: Enhanced sialylation of mucin-associated carbohydrate structures in human colon cancer metastasis. Gastroenterology 110: 1354-1367, 1996.