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Volumn 45, Issue 9, 2010, Pages 3558-3563
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Synthesis and evaluation of quinazolinone derivatives as inhibitors of NF-κB, AP-1 mediated transcription and eIF-4E mediated translational activation: Inhibitors of multi-pathways involve in cancer
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Author keywords
AP 1; eIF 4E; Molecular modeling; NF B; Quinazolinone derivatives; Thiazole derivatives; Transcription factors; Translational factor
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Indexed keywords
2 (2 METHYLAMINO 4 PHENYL THIAZOL 5 YL) 3 PHENYL 3H QUINAZOLIN 4 ONE;
2 (2,4 DISUBSTITUTED THIAZOLE 5 YL) 3 ARYL 3H QUINAZOLIN 4 ONE;
2 [2 (4 CHLORO PHENYLAMINO) 4 PHENYL THIAZOL 5 YL] 3 (4 METHOXY PHENYL) 3H QUINAZOLIN 4 ONE;
2 [2 (4 CHLORO PHENYLAMINO) 4 PHENYL THIAZOL 5 YL] 3 PHENYL 3H QUINAZOLIN 4 ONE;
3 (4 CHLORO PHENYL) 2 (2 METHYLAMINO 4 PHENYL THIAZOL 5 YL) 3H QUINAZOLIN 4 ONE;
3 (4 CHLORO PHENYL) 2 (4 METHYL 2 METHYLAMINO THIAZOL 5 YL) 3H QUINAZOLIN 4 ONE;
3 (4 CHLORO PHENYL) 2 (4 METHYL 2 PHENYLAMINO THIAZOL 5 YL) 3H QUINAZOLIN 4 ONE;
3 (4 CHLORO PHENYL) 2 [2 (4 CHLORO PHENYLAMINO) 4 METHYL THIAZOL 5 YL] 3H QUINAZOLIN 4 ONE;
3 (4 METHOXY PHENYL) 2 (4 PHENYL 2 PHENYLAMINO THIAZOL 5 YL) 3H QUINAZOLIN 4 ONE;
3 PHENYL 2 (4 PHENYL 2 PHENYLAMINO THIAZOL 5 YLL) 3H QUINAZOLIN 4 ONE;
IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;
INITIATION FACTOR 4E;
MOLECULAR SCAFFOLD;
QUINAZOLINONE DERIVATIVE;
SMALL MOLECULE TRANSPORT AGENT;
TRANSCRIPTION FACTOR;
UNCLASSIFIED DRUG;
ARTICLE;
BIOLOGICAL ACTIVITY;
CANCER GROWTH;
CELL STRAIN HEK293;
DRUG SYNTHESIS;
HUMAN;
HUMAN CELL;
NEOPLASM;
TRANSLATION INITIATION;
ANTINEOPLASTIC AGENTS;
BASE SEQUENCE;
CELL LINE;
EUKARYOTIC INITIATION FACTOR-4E;
HUMANS;
INHIBITORY CONCENTRATION 50;
MODELS, MOLECULAR;
NEOPLASMS;
NF-KAPPA B;
PROTEIN BIOSYNTHESIS;
PROTEIN CONFORMATION;
QUINAZOLINONES;
TRANSCRIPTION FACTOR AP-1;
TRANSCRIPTION, GENETIC;
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EID: 77955556391
PISSN: 02235234
EISSN: 17683254
Source Type: Journal
DOI: 10.1016/j.ejmech.2010.04.038 Document Type: Article |
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Times cited : (37)
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References (33)
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