Structure-activity relationship studies of ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine- 5-carboxylate: An inhibitor of AP-1 and NF-κB mediated gene expression

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 18, 2002, Pages 2573-2577

  Palanki, Moorthy S S ^a   Gayo Fung, Leah M ^a   Shevlin, Graziella I ^a   Erdman, Paul ^a   Sato, Mark ^a   Goldman, Mark ^a   Ransone, Lynn J ^a   Spooner, Cheryl ^a  

^a CELGENE CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; ETHYL 2 [3 METHYL 2,5 DIOXO (3 PYRROLINYL)AMINO] 4 (TRIFLUOROMETHYL)PYRIMIDINE 5 CARBOXYLATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; GENE EXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE;

GENE EXPRESSION REGULATION; HUMANS; JURKAT CELLS; NF-KAPPA B; PYRIMIDINES; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTOR AP-1;

EID: 0037119678     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00517-6     Document Type: Article

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