Elevated cerebrospinal fluid adiponectin and adipsin levels in patients with multiple sclerosis: A Finnish co-twin study

European Journal of Neurology

Volumn 17, Issue 2, 2010, Pages 332-334

  Hietaharju, A ^a   Kuusisto, H ^a   Nieminen, R ^b   Vuolteenaho, K ^b   Elovaara, I ^a   Moilanen, E ^b  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

Adipocytokine; Adiponectin; Adipsin; Immunopathogenesis; Leptin; Multiple sclerosis

Indexed keywords

ADIPONECTIN; ADIPSIN; BETA INTERFERON; INTERLEUKIN 6; LEPTIN;

ADULT; ARTICLE; BLOOD SAMPLING; BODY MASS; CEREBROSPINAL FLUID ANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME IMMUNOASSAY; FEMALE; HUMAN; MALE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CEREBROSPINAL FLUID LEVEL; TWIN DISCORDANCE;

ADIPONECTIN; ADULT; COMPLEMENT FACTOR D; DISEASES IN TWINS; FEMALE; FINLAND; HUMANS; IMMUNOENZYME TECHNIQUES; INTERLEUKIN-6; LEPTIN; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC;

EID: 74549218763     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2009.02701.x     Document Type: Article

References (12)

1. Tilg H, Moschem AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 2006 6 : 772 783.
2. Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 2005 115 : 911 919.
3. Matarese G, Procaccini C, De Rosa V. The intricate interface between immune and metabolic regulation: a role for leptin in the pathogenesis of multiple sclerosis? J Leukoc Biol 2008 84 : 1 7.
4. Sanna V, Di Giacomo A, La Cava A, et al. Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses. J Clin Invest 2003 111 : 241 250.
5. Kuusisto H, Kaprio J, Kinnunen E, Luukkaala T, Koskenvuo M, Elovaara I. Concordance and heritability of multiple sclerosis in Finland: study on a nationwide series of twins. Eur J Neurol 2008 10 : 1106 1110.
6. + regulatory T cells. Proc Natl Acad Sci USA 2005 102 : 5150 5155.
7. Frisullo G, Mirabella M, Angelucci F, et al. The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing-remitting multiple sclerosis. J Neuroimmunol 2007 192 : 174 183.
8. Batocchi AP, Rotondi M, Caggiula M, et al. Leptin as a marker of multiple sclerosis activity in patients treated with interferon-beta. J Neuroimmunol 2003 139 : 150 154.
9. Chatzantoni K, Papathanassopoulos P, Gourzoulidou E, Mouzaki A. Leptin and its soluble receptor in plasma of patients suffering from remitting-relapsing multiple sclerosis (MS): in vitro effects of leptin on type-1 and type-2 cytokine secretion by peripheral blood mononuclear cells, T-cells and monocytes of MS patients. J Autoimmun 2004 23 : 169 177.
10. Saijo S, Nagata K, Nakano Y, Tobe T, Kobayashi Y. Inhibition by adiponectin of IL-8 production by human macrophages upon coculturing with late apoptotic cells. Biochem Biophys Res Commun 2005 334 : 1180 1183.
11. Xu Y, Ma M, Ippolito GC, Schroeder HW Jr., Carroll MC, Volanakis JE. Complement activation in factor D-deficient mice. Proc Natl Acad Sci USA 2001 98 : 14577 14582.
12. Presle N, Pottie P, Dumond H, et al. Differential distribution of adipokines between serum and synovial fluid in patients with osteoarthritis. Contribution of joint tissues to their articular production. Osteoarthritis Cartilage 2006 14 : 690 695.