Feasibility, safety, and efficacy of directly transplanting autologous adult bone marrow stem cells in patients with chronic traumatic dorsal cord injury: A pilot clinical study

Neurosurgery Quarterly

Volumn 20, Issue 3, 2010, Pages 216-226

  Abdelaziz, Osama S ^a   Marie, Ahmed ^a   Abbas, Mohamed ^a   Ibrahim, Mohamed ^a   Gabr, Hala ^b  

^a ALEXANDRIA UNIVERSITY   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

Author keywords

bone marrow; neural regeneration; spinal cord injury; stem cells

Indexed keywords

ANALGESIC AGENT;

ADOLESCENT; ADULT; ARTICLE; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; BRAIN ELECTROPHYSIOLOGY; CHILD; CHILL; CHRONIC TRAUMATIC DORSAL CORD INJURY; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE DURATION; FEASIBILITY STUDY; FEMALE; FEVER; FLUID THERAPY; HEADACHE; HEMATOPOIETIC STEM CELL; HUMAN; LAMINECTOMY; LIQUORRHEA; MALE; MORBIDITY; NUCLEAR MAGNETIC RESONANCE IMAGING; PARENCHYMA; PATIENT SAFETY; PILOT STUDY; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SPINAL CORD; SPINAL CORD DISEASE; SPINAL CORD INJURY; SPINAL CORD LESION; SPINAL CORD MALACIA; SURGICAL TECHNIQUE; TREATMENT OUTCOME;

EID: 77955522014     PISSN: 10506438     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNQ.0b013e3181dce9f2     Document Type: Article

References (51)

1. Lobosky JM. The epidemiology of spinal cord injury. In: Narayan RK, Wilberger JE, Povlishock JT, eds. Neurotrauma. New York: McGraw Hill; 1996:1049-1058.
2. Lindsay KW, Bone I, Callender R. Neurology and Neurosurgery Illustrated. New York: Churchill Livingstone; 1991:399-402.
3. Berkowitz M, Harvey C, Greene C, et al. The economic consequences of traumatic spinal cord injury. New York: Demos; 1992:20-33.
4. Sekhon LHS, Fehlings MG. Epidemiology, demographics, and pathophysiology of acute spinal cord injury. Spine. 2001;26 (24 suppl):S2-S12.
5. Himes BT, Neuhuber B, Coleman C, et al. Recovery of function following grafting of human bone marrow-derived stromal cells into the injured spinal cord. Neurorehabil Neural Repair. 2006;20: 278-296.
6. Sugar O, Gerard RW. Spinal cord regeneration in the rat. J Neurophysiol. 1940;3:1-19.
7. Barnard JW, Carpenter W. Lack of regeneration in the spinal cord of the rat. J Neurophysiol. 1950;13:223-228.
8. Feigin I, Geller EH, Wolf A. Absence of regeneration in the spinal cord of the young rat. J Neuropathol Exp Neurol. 1951;10:420-425.
9. Kao CC. Comparison of healing process in transected spinal cords grafted with autogenous brain tissue, sciatic nerve, and nodose ganglion. Exp Neurol. 1974;44:424-439.
10. Guest JD, Rao A, Olson L, et al. The ability of human Schwann cell grafts to promote regeneration in the transected nude rat spinal cord. Exp Neurol. 1997;148:502-522.
11. Doucette R. Olfactory ensheathing cells: potential for glial cell transplantation into areas of CNS injury. Histol Histopathol. 1995; 10:503-507.
12. Reynolds BA, Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science. 1992;255:1707-1710.
13. Snyder EY. Grafting immortalized neurons to the CNS. Curr Opin Neurol Biol. 1994;4:742-751.
14. Wilmut I, Schnieke AE, McWhir J, et al. Viable offspring derived from fetal and adult mammalian cells. Nature. 1997;385:810-813.
15. Thomson JA, Itskovitz-Eldor J, Shapiro SS, et al. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282: 1145-1147.
16. Fuchs E, Serge JA. Stem cells: a new lease on life. Cell. 2000;100:143-155.
17. Sell S. Adult stem cell plasticity: introduction to the first issue of stem cell reviews. Stem Cell Rev. 2005;1:1-7.
18. Chiu AY, Hall ZW. Stem cell research: the California experience. J Neurosci. 2006;26:6661-6663.
19. Svendsen CN, Caldwell MA, Ostenfeld T. Human neural stem cells: isolation, expansion and transplantation. Brain Pathol. 1999;9: 499-513.
20. Ourednik V, Ourednik J, Park KI, et al. Neural stem cells-a versatile tool for cell replacement and gene therapy in the central nervous system. Clin Genet. 1999;56:267-278.
21. Gage FH. Mammalian neural stem cells. Science. 2000;287: 1433-1438.
22. Wickelgren I. Stem cells. Rat spinal cord function partially restored. Science. 1999;286:1826-1827.
23. Liu Y, Himes BT, Solowska J, et al. Intraspinal delivery of neurotrophin-3 using neural stem cells genetically modified by recombinant retrovirus. Exp Neurol. 1999;158:9-26.
24. McDonald JW, Liu XZ, Qu Y, et al. Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord. Nat Med. 1999;5:1410-1412.
25. Prentice D. Adult stem cells. In: Prentice D, ed. Monitoring Stem Cell Research: A Report of the President s Council on Bioethics, Appendix K. Washington, DC: Government Printing Office; 2004: 309-346.
26. D Ippolito G, Diabira S, Howard GA, et al. Marrow-isolated adult multilineage inducible (MIAMI) cells, a unique population of postnatal young and old human cells with extensive expansion and differentiation potential. J Cell Sci. 2004;117(Pt 14): 2971-2981.
27. Kögler G, Sensken S, Airey JA, et al. A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. J Exp Med. 2004;200:123-135.
28. Jiang Y, Jahagirda BN, Reinhardt RL, et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 2002;418: 41-49.
29. Mazurier F, Doedens M, Gan OI, et al. Rapid myeloerythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cells. Nat Med. 2003;9:959-963.
30. Bianco P, Riminucci M, Gronthos S, et al. Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells. 2001;19:180-192.
31. Heissig B, Hattori K, Dias S, et al. Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell. 2002;109:625-637.
32. Carvalho KA, Vialle EN, Moreira GHG, et al. Functional outcome of bone marrow stem cells (CD45+/CD34-) after cell therapy in chronic spinal cord injury in Wistar rats. Transplant Proc. 2008;40:845-846.
33. Čžková D, Rosocha J, Vanický I, et al. Transplants of human mesenchymal stem cells improve Functional recovery after spinal cord injury in the rat. Cell Mol Neurobiol. 2006;26:1167-1180.
34. Lee KH, Suh-Kim H, Choi JS, et al. Human mesenchymal stem cell transplantation promotes functional recovery following acute spinal cord injury in rats. Acta Neurobiol Exp (Warsz). 2007;67: 13-22.
35. Deng YB, Liu XG, Liu ZG, et al. Implantation of BMmesenchymal stem cells into injured spinal cord elicits de novo neurogenesis and functional recovery: evidence from a study in rhesus monkeys. Cytotherapy. 2006;8:210-214.
36. Rabinovich S, Seledtsov V, Poveschenko O, et al. Transplantation treatment of spinal cord injury patients. Biomed Pharmacother. 2003;57:428-433.
37. Zhou Q, Zhang SZ, Xu RX, et al. Neural stem cell transplantation and postoperative management: report of 70 cases. Di Yi Jun Yi Da Xue Xue Bao. 2004;24:1207-1209.
38. Kang KS, Kim SW, Oh YH, et al. A 37-year-old spinal cord-injured female patient, transplanted of multipotent stem cells from human UC blood, with improved sensory perception and mobility, both functionally and morphologically: a case study. Cytotherapy. 2005;7:368-373.
39. Féron F, Perry C, Cochrane J, et al. Autologous olfactory ensheathing cell transplantation in human spinal cord injury. Brain. 2005;128(Pt 12):2951-2960.
40. Lima C, Pratas-Vital J, Escada P, et al. Olfactory mucosa autografts in human spinal cord injury: a pilot clinical study. J Spinal Cord Med. 2006;29:191-203.
41. Moviglia GA, Fernandez Viña R, Brizuela JA, et al. Combined protocol of cell therapy for chronic spinal cord injury. Report on the electrical and functional recovery of two patients. Cytotherapy. 2006;8:202-209.
42. Deda H, Inci MC, Kurekci AE, et al. Treatment of chronic spinal cord injured patients with autologous bone marrow-derived hematopoietic stem cell transplantation: 1-year follow-up. Cytotherapy. 2008;10:565-574.
43. Subbaiah G, Adavi V, Chelluri LK, et al. Preliminary report on the safety, efficacy and functional recovery of spinal cord injury with autologous bone marrow derived mesenchymal stem cells - a clinical trial. Int J Spine Surg. 2009;5:1-6.
44. Callera F, do Nascimento RX. Delivery of autologous bone marrow precursor cells into the spinal cord via lumbar puncture technique in patients with spinal cord injury: a preliminary safety study. Exp Hematol. 2006;34:130-131.
45. Bakshi A, Barshinger AL, Swanger SA, et al. Lumbar puncture delivery of bone marrow stromal cells in spinal cord contusion: a novel method for minimally invasive cell transplantation. J Neurotrauma. 2006;23:55-65.
46. Satake K, Lou J, Lenke LG. Migration of mesenchymal stem cells through cerebrospinal fluid into injured spinal cord tissue. Spine. 2004;29:1971-1979.
47. Takeuchi H, Natsume A, Wakabayashi T, et al. Intravenously transplanted human neural stem cells migrate to the injured spinal cord in adult mice in an SDF-1- and HGF-dependent manner. Neurosci Lett. 2007;426:69-74.
48. Huang H, Chen L, Wang H, et al. Influence of patients age on functional recovery after transplantation of olfactory ensheathing cells into injured spinal cord injury. Chin Med J. 2003;116: 1488-1491.
49. Barami K, Diaz FG. Cellular transplantation and spinal cord injury. Neurosurgery. 2000;47:691-700.
50. Saberi H, Moshayedi P, Aghayan HR, et al. Treatment of chronic thoracic spinal cord injury patients with autologous Schwann cell transplantation: an interim report on safety considerations and possible outcomes. Neurosci Lett. 2008;443:46-50.
51. Webber DJ, Bradbury EJ, McMahon SB, et al. Transplanted neural progenitor cells survive and differentiate but achieve limited functional recovery in the lesioned adult rat spinal cord. Regen Med. 2007;2:929-945.