Human mesenchymal stem cell transplantation promotes functional recovery following acute spinal cord injury in rats

Acta Neurobiologiae Experimentalis

Volumn 67, Issue 1, 2007, Pages 13-22

  Kyung, Hee Lee ^a,b   Suh Kim, Haeyoung ^c   Ji, Soo Choi ^a,b   Jeun, Sin Soo ^d   Eun, Jin Kim ^a,b   Kim, Sung Soo ^c   Do, Heum Yoon ^b   Bae, Hwan Lee ^a,b  

^a Brain Research Institute   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c Ajou University School of Medicine   (South Korea)

^d The Catholic University of Korea   (South Korea)

Author keywords

Behavioral test; Electrophysiology; Human mesenchymal stem cell; Spinal cord injury; Transplantation

Indexed keywords

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; CELL DIFFERENTIATION; CELL REGENERATION; CONTROLLED STUDY; EVOKED MUSCLE RESPONSE; EVOKED SOMATOSENSORY RESPONSE; FUNCTIONAL STATUS; HEART FUNCTION TEST; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; RAT; SPINAL CORD INJURY; TREATMENT OUTCOME;

ADOLESCENT; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; CHILD; ELECTRIC STIMULATION; EVOKED POTENTIALS; FUNCTIONAL LATERALITY; HINDLIMB; HUMANS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; NERVE TISSUE PROTEINS; NEURAL CONDUCTION; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; RECOVERY OF FUNCTION; SCIATIC NERVE; SPINAL CORD INJURIES; TRANSPLANTATION, HETEROLOGOUS;

EID: 34247400229     PISSN: 00651400     EISSN: 00651400     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Azizi SA, Stokes D, Augelli BJ, DiGirolamo C, Prockop DJ (1998) Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats - similarities to astrocyte grafts. Proc Natl Acad Sci U S A 95: 3908-3913.
2. Basso DM, Beattie MS, Bresnahan (1996) Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transaction. Exp Neurol 139: 244-256.
3. Blesch A, Tuszynski MH (2003) Cellular GDNF delivery promotes growth of motor and dorsal column sensory axons after partial and complete spinal cord transections and induces remyelination. J Comp Neurol 467: 403-417.
4. Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL (1994) Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 53: 55-63.
5. Chopp M, Zhang XH, Li Y, Wang L, Chen J, Lu D, Lu M (2000) Rosenblum, Spinal cord injury in rat: Treatment with bone marrow stromal cell transplantation. Neuroreport 11: 3001-3005.
6. Constantini S, Young W (1994) The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats. J Neurosurg 80: 97-111.
7. Davies SJA, Goucher DR, Doller C, Silver J (1999) Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cord. J Neurosci 19: 5810-5822.
8. Dixon WJ (1980) Efficient analysis of experimental observation. Annu Rev Pharmacol Toxicol 20: 441-462.
9. Falci S, Holtz A, Akesson E, Azizi M, Ertzgaard P, Hultling C, Kjaeldgaard A, Levi R, Ringden O, Westgren M, Lammertse D, Seige A (1997) Obliteration of a posttraumatic spinal cord cyst with solid human embryonic spinal cord grafts: First clinical attempt. J Neurotrauma 14: 875-884.
10. Gruner JA (1992) A monitored contusion model of spinal cord injury in the rat. J Neurotrauma 9: 123-126
11. Himes BT, Neuhuber B, Coleman C, Kushner R, Swanger SA, Kopen GC, Wagner J, Shumsky JS, Fischer I (2006) Recovery of function following grafting of human bone marrow-derived stromal cells into the injured spinal cord. Neurorehabil Neural Repair 20: 278-296.
12. Hofstetter CP, Schwarz EJ, Hess D, Widenfalk J, El Manira A, Prockop DJ, Olson L (2002) Marrow stromal cells from guiding strands in the injured spinal cord and promote recovery. Proc Natl Acad Sci U S A 99: 2199-2204.
13. Jones LL, Sajed D, Tuszynski MH (2003) Axonal regeneration through regions of chondroitin sulfate proteoglycan deposition after spinal cord injury: A balance of permissiveness and inhibition. J Neurosci 23: 9276-9288.
14. Kopen GC, Prockop DJ, Phinney DG (1999) Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci U S A 96: 10711-10716.
15. Lee BH, Lee KH, Kim UJ, Yoon DH, Sohn JH, Choi SS, Yi IG, Park YG (2004) Injury in the spinal cord may produce cell death in the brain. Brain Res 1020: 37-44
16. Lee KH, Yoon DH, Park YG, Lee BH (2005) Effects of glial transplantation on functional recovery following acute spinal cord injury. J Neurotrauma 22: 575-589.
17. Li Y, Chen J, Wang L, Lu M, Chopp M (2001) Treatment of stroke in rat with intracarotid administration of marrow stromal cells. Neurology 56: 1666-1672.
18. Lindsey AE, LoVerso RL, Tovar CA, Hill CE, Beattie MS, Bresnahan JC (2004) An analysis of changes in sensory thresholds to mild tactile and cold stimuli after experimental spinal cord injury in the rat. Neurorehabil Neural Repair 14: 287-300.
19. Lu D, Mahmood A, Wang L, Li Y, Chopp M (2000) Adult bone marrow stromal cells administered intravenously to rats after traumatic brain injury migrate into brain and improve neurological outcome. Neuroreport 12: 559-563.
20. Lu D, Li Y, Wang L, Chen J, Mahmood A, Chopp M (2001) Intraarterial administration of marrow stromal cells in a rat model of traumatic brain injury. J Neurotrauma 18: 813-819.
21. Lu P, Blesch A, Tuszynski MH (2004) Induction of bone marrow stromal cells to neurons: Differentiation, transdifferentiation, or artifact? J Neurosci Res 77: 174-191.
22. Lu P, Jones LL, Tuszynski MH (2005) BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury. Exp Neurol 191: 344-360.
23. Mahmood A, Lu D, Wang L, Li Y, Chopp M (2001) Treatment of traumatic brain injury in female rats with intravenous administration of bone marrow stromal cells. Neurosurgery 49: 1196-1204.
24. McDonald JW, Liu XZ, Qu Y, Liu S, Mickey SK, Turetsky D, Gottlieb DI, Choi DW (1999) Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord. Nat Med 5: 1410-1412.
25. Morgenstern DA, Asher RA, Fawcett JW (2002) Chondroitin sulphate proteoglycans in the CNS injury response. Prog Brain Res 137: 313-332.
26. Neuhuber B, Gallo G, Howard L, Kostura L, Mackay A Fischer I (2004) Reevaluation of in vitro differentiation protocols for bone marrow stromal cells: Disruption of actin cytoskeleton induces rapid morphological changes and mimics neuronal phenotype. J Neurosci Res 77: 192-204.
27. Neuhuber B, Himes BT, Shumsky JS, Gallo G, Fischer I (2005) Axon growth and recovery of function supported by human bone marrow stromal cells in the injured spinal cord exhibit donor variations. Brain Res 1035: 73-85.
28. Qiu J, Cai D, Filbin MT (2002) A role for cAMP in regeneration during development and after injury. Prog Brain Res 137: 381-387.
29. Sanchez-Ramos JR, Song S, Cardozo-Pelaez F, Hazzi C, Stedeford T, Willing A, Freeman TB, Saporta WS, Janssen W, Patel N, Cooper DR, Sanberg P (2000) Adult bone marrow stromal cells differentiate into neural cell in vitro. Exp Neurol 164: 247-256.
30. Schwab ME, Bartholdi D (1996) Degeneration and regeneration of axons in the lesioned spinal cord. Physiol Rev 76 319-370.
31. Tuszynski MH, Kordower JH (1999) CNS Regeneration: Basic Science and Clinical Advances. Academic Press, San Diego.
32. Woodbury D, Schwarz EJ, Prockop DJ, Black IB (2000) Adult rat and human bone marow stromal cells differentiate into neurons. J Neurosci Res 61: 364-370.
33. Wu S, Suzuki Y, Ejiri Y, Noda T, Bai H, Kitada M, Kataoka K, Ohta M, Chou H, Ide C (2003) Bone marrow stromal cells enhance differentiation of cocultured neurosphere cells and promote regeneration of injured spinal cord. J Neurosci Res 72: 343-351.
34. Yoon YW, Dong H, Arends JJ, Jacquin MF (2004) Mechanical and cold allodynia in a rat spinal cord contusion model. Somatosens Mot Res 21: 25-31.
35. Zurita M, Vaquero J (2004) Functional recovery in chronic paraplegia after bone marrow stromal cells transplantation. Neuroreport 15: 1105-1108.
36. Zurita M, Vaquero J (2006) Bone marrow stromal cells can achieve cure of chronic paraplegic rats: Functional and morphological outcome one year after transplantation. Neurosci Lett 402: 51-56.