Differential effects of ICA-27243 on cloned KV7 channels

Pharmacology

Volumn 86, Issue 3, 2010, Pages 174-181

  Blom, Sigrid Marie ^a,b   Schmitt, Nicole ^b   Jensen, Henrik Sindal ^a  

^a H LUNDBECK A S   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Functional effects; ICA 27243; KV7 channel openers; KCNQ channels; M current; Potassium channel; Retigabine

Indexed keywords

BENZAMIDE DERIVATIVE; N (6 CHLOROPYRIDIN 3 YL) 3,4 DIFLUOROBENZAMIDE; POTASSIUM CHANNEL KCNQ2; POTASSIUM CHANNEL KCNQ4; RETIGABINE; RUBIDIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; ELECTROPHYSIOLOGY; NONHUMAN; OOCYTE; PRIORITY JOURNAL; VOLTAGE CLAMP; XENOPUS LAEVIS;

ANIMALS; BENZAMIDES; BINDING SITES; CARBAMATES; CELLS, CULTURED; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; CRICETULUS; FEMALE; KCNQ POTASSIUM CHANNELS; KCNQ2 POTASSIUM CHANNEL; MEMBRANE POTENTIALS; OOCYTES; PHENYLENEDIAMINES; PYRIDINES; RUBIDIUM RADIOISOTOPES; XENOPUS LAEVIS;

EID: 77955520190     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000317525     Document Type: Article

References (16)

1. Jentsch TJ: Neuronal KCNQ potassium channels: physiology and role in disease. Nat Rev Neurosci 2000; 1:21-30.
2. Tatulian L, Delmas P, Abogadie FC, Brown DA: Activation of expressed KCNQ potassium currents and native neurona l M-t y pe potassium currents by the anti-convulsant drug retigabine. J Neurosci 2001; 21: 5535-5545.
3. Wickenden AD, Zou A, Wagoner PK, Jegla T: Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells. Br J Pharmacol 2001; 132: 381-38 4.
4. Wuttke T V, Seebohm G, Bail S, Maljevic S, Lerche H: The new anticonvulsant retiga-bine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate. Mol Pharmacol 2005; 67: 1009-1017.
5. + channel sensitivity to the anticonvulsant retiga-bine. J Neurosci 2005; 25:5051-5060.
6. Bentzen BH, Schmitt N, Calloe K, Dalby-Brown W, Grunnet M, Olesen SP: The acryl-amide (S)-1 differentially affects Kv7 (KCNQ) potassium channels. Neurophar-macolog y 2006; 51: 106 8-1077.
7. Wickenden AD, Krajewski JL, London B, Wagoner PK, Wilson WA, Clark S, Roeloffs R, Naughton-Smith G, Rigdon GC: N-(6-Chloro-pyridin-3-yl)-3,4-dif luoro-benza-mide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator. Mol Pharmacol 2008; 73: 977-986.
8. Main MJ, Cryan JE, Dupere JRB, Cox B, Clare JJ, Burbidge SA: Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine. Mol Pharmacol 2000; 58: 253-262.
9. Padilla K, Wickenden AD, Gerlach AC, Mc-Cormack K: The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site. Neurosci Lett 2009; 465: 138-142.
10. V 7 (KCNQ) channel modulators: an update. Expert Opin Ther Tar 2008; 12: 565-581.
11. V 7 channels expressed in Xenopus laevis oocytes. PLoS ONE 2009; 4:e8251.
12. Xiong Q, Sun H, Zhang Y, Nan F, Li M: Combinatorial augmentation of voltage-gated KCNQ potassium channels by chemical openers. Proc Natl Acad Sci USA 2008; 105: 312 8-3133.
13. Hansen HH, Ebbesen C, Mathiesen C, Wei-kop P, Ronn LC, Waroux O, Scuvee-Moreau J, Seutin V, Mikkelsen JD: The KCNQ channel opener retigabine inhibits the activity of mesencephalic dopaminergic systems of the rat. J Pharmacol Exp Ther 2006; 318:1006-1019.
14. Hansen HH, Andreasen JT, Weikop P, Mirza N, Scheel-Kruger J, Mikkelsen JD: The neu-ronal KCNQ channel opener retigabine inhibits locomotor activity and reduces fore-brain excitatory responses to the psycho-stimulants cocaine, methylphenidate and phencyclidine. Eur J Pharmacol 2007; 570: 77-88.
15. Sotty F, Damgaard T, Montezinho LP, Mork A, Olsen CK, Bundgaard C, Husum H: Anti-psychotic-like effect of retigabine [N-(2-amino-4-[fluorobenzylamino]- phenyl)car-bamic acid ester], a KCNQ potassium channel opener, via modulation of meso-limbic dopaminergic neurotransmission. J Pha rmacol Exp Ther 2009; 32 8: 951-9 62.
16. Schrøder RL, Strobaek D, Olesen SP, Chris-tophersen P: Voltage-independent KCNQ4 currents induced by (+/-)BMS-204352. Pf lugers Arch 2003; 446: 607-616.