Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers

Chemico-Biological Interactions

Volumn 187, Issue 1-3, 2010, Pages 362-369

  Ashani, Y ^a   Gupta, R D ^a   Goldsmith, M ^a   Silman, I ^a   Sussman, J L ^a   Tawfik, D S ^a   Leader, H ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Acetylcholinesterase; Catalytic bioscavenger; Coumarin; Directed evolution; Fluorogenic organophosphate; Nerve agent; Paraoxonase

Indexed keywords

ACETYLCHOLINESTERASE; ARYLDIALKYLPHOSPHATASE 1; CHOLINESTERASE INHIBITOR; FLUORIDE SODIUM; ORGANOPHOSPHORUS COMPOUND; RECOMBINANT ENZYME; SCAVENGER;

ARTICLE; CATALYSIS; CHEMICAL REACTION KINETICS; CLONE; CONTROLLED STUDY; DRUG SCREENING; ENANTIOMER; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; FLUORESCENCE ACTIVATED CELL SORTING; HIGH THROUGHPUT SCREENING; HYDROLYSIS; ISOMER; RACEMIC MIXTURE; RELIABILITY; SENSITIVITY ANALYSIS; STEREOSPECIFICITY; SYNTHESIS; X RAY DIFFRACTION;

MAMMALIA;

EID: 77955518989     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.02.039     Document Type: Article

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