A comparison of hepatitis B viral markers of patients in different clinical stages of chronic infection

Hepatology International

Volumn 4, Issue 2, 2010, Pages 516-522

  Tong, Myron John ^a,b   Hsu, Leeyen ^b   Hsien, Carlos ^b   Kao, Jia Horng ^c   Durazo, Francisco Antonio ^a   Saab, Sammy ^a   Blatt, Lawrence Mitchell ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HUNTINGTON MEDICAL RESEARCH INSTITUTES   (United States)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^d AliosBiopharma   (United States)

Author keywords

Basal core promoter mutant; Chronic hepatitis; Cirrhosis; Genotype; HBeAg; HBV DNA; Immune tolerant; Inactive carriers; Precore mutant

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; BIOLOGICAL MARKER; HEPATITIS B(E) ANTIGEN; VIRUS DNA;

ADULT; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DEATH; FEMALE; FOLLOW UP; GENOTYPE; HEALTH STATUS; HEPATITIS B; HUMAN; IMMUNOLOGICAL TOLERANCE; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; PROSPECTIVE STUDY; VIROLOGY; VIRUS MUTANT;

EID: 77955513644     PISSN: 19360533     EISSN: 19360541     Source Type: Journal    
DOI: 10.1007/s12072-010-9179-1     Document Type: Article

References (30)

1. MJ Tong C Hsien L Hsu HE Sun LM Blatt 2008 Treatment recommendations for chronic hepatitis B: an evaluation of current guidelines based on a natural history study in the United States Hepatology 48 1070 1078 10.1002/hep.22476 18688879
2. S Pungpapong WR Kim JJ Poterucha 2007 Natural history of hepatitis B virus infection: an update for clinicians Mayo Clin Proc 82 967 975 10.4065/82.8.967 1:CAS:528:DC%2BD2sXpslertL8%3D 17673066
3. CK Hui N Leung ST Yuen HY Zhang KW Leung L Lu, et al. 2007 Natural history and disease progression in Chinese chronic hepatitis B patients in immune-tolerant phase Hepatology 46 395 401 10.1002/hep.21724 17628874 (Pubitemid 47344774)
4. UH Iloeje HI Yang J Su CL Jen SL You CJ Chen 2006 Predicting cirrhosis risk based on the level of circulating hepatitis B viral load Gastroenterology 130 678 686 10.1053/j.gastro.2005.11.016 16530509 (Pubitemid 43374518)
5. CJ Chen HW Yang J Su CL Jen SL You SN Lu, et al. 2006 Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level JAMA 295 65 73 10.1001/jama.295.1.65 1:CAS:528:DC%2BD28XhtlKqtQ%3D%3D 16391218 (Pubitemid 43042691)
6. HI Yang SH Yeh PJ Chen UH Iloeje CJ Jen J Su, et al. 2008 Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma J Natl Cancer Inst 100 1134 1143 10.1093/jnci/djn243 1:CAS:528:DC%2BD1cXhtFKrsb7P 18695135
7. MJ Tong LM Blatt JH Kao JT Cheng WG Corey 2006 Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma World J Gastroenterol 12 6620 6626 1:CAS:528:DC%2BD2sXntVahs7o%3D 17075974
8. H Yotsuyanagi K Hino E Tomita J Toyoda K Yasuda S Iino 2002 Precore and core promoter mutations, hepatitis B virus DNA levels and progressive liver injury in chronic hepatitis B J Hepatol 37 355 363 10.1016/S0168-8278(02)00180-0 1:CAS:528:DC%2BD38XmtVSmt7s%3D 12175631 (Pubitemid 34969952)
9. JH Kao PJ Chen MY Lai DS Chen 2003 Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers Gastroenterology 24 327 334 10.1053/gast.2003.50053 (Pubitemid 36169249)
10. WF Carman MR Jacyna S Hadziyannis P Karayiannis MJ McGarvey A Makris, et al. 1989 Mutations preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection Lancet 2 588 591 10.1016/S0140-6736(89)90713- 7 1:STN:280:DyaL1MzmtlOqsw%3D%3D 2570285
11. CM Hunt JM McGill MI Allen LD Condreay 2000 Clinical relevance of hepatitis B viral mutations Hepatology 31 1037 1044 10.1053/he.2000.6709 1:CAS:528:DC%2BD3cXjtlyltb0%3D 10796877
12. Wilt TJ, Shamliyan T, Shaukat A, Taylor BC, MacDonald R, Yuan JM, et al. Management of chronic hepatitis B. Evidence Report/Technology Assessment No. 174. AHRQ Publication No. 09-E002. Rockville, MD: Agency for Healthcare Research and Quality; October 2008. Prepared by the Minnesota Evidence-based Practice Center under Contract No. 290-02-0009
13. AS Lok EJ Heathcote JH Hoofnagle 2001 Management of hepatitis B: 2000-summary of a workshop Gastroenterology 120 1828 1853 10.1053/gast.2001. 24839 1:STN:280:DC%2BD3M3ps1Gnsw%3D%3D 11375963
14. G Fattovich F Bortolotti F Donato 2008 Natural history of chronic hepatitis B: special emphasis on disease progression and prognostic factors J Hepatol 48 335 352 10.1016/j.jhep.2007.11.011 18096267
15. MJ Tong C Hsien JJ Song JH Kao HE Sun L Hsu, et al. 2009 Factors associated with progression to hepatocellular carcinoma and to death from liver complications in patients with HBsAg-positive cirrhosis Dig Dis Sci 54 1337 1346 10.1007/s10620-009-0747-y 1:CAS:528:DC%2BD1MXlsFKrtbk%3D 19242792
16. JH Kao PJ Chen MY Lai DS Chen 2002 Genotypes and clinical phenotypes of hepatitis B virus in patients with chronic hepatitis B virus infection J Clin Microbiol 40 1207 1209 10.1128/JCM.40.4.1207-1209.2002 11923332 (Pubitemid 34279876)
17. CJ Chu M Hussain AS Lok 2002 Hepatitis B virus genotype B is associated with earlier HBeAg seroconversion compared with hepatitis B virus genotype C Gastroenterology 122 1756 1762 10.1053/gast.2002.33588 1:CAS:528: DC%2BD38Xlt12gsrc%3D 12055581
18. JH Kao PJ Chen MY Lai DS Chen 2004 Hepatitis B virus genotype and spontaneous hepatitis B e antigen seroconversion in Taiwanese hepatitis B carriers J Med Virol 72 363 369 10.1002/jmv.10534 1:CAS:528:DC%2BD2cXhvVCjtL8%3D 14748059 (Pubitemid 38133976)
19. BG Chen CJ Liu GM Jow Pj Chen JH Kao DS Chen 2006 High prevalence and mapping the pre-S deletion in hepatitis B virus carriers with progressive liver disease Gastroenterology 130 1153 1168 10.1053/j.gastro.2006.01.011 1:CAS:528:DC%2BD28XksFWmurY%3D 16618410
20. SJ Hadsiyannis GV Papatheodoridis 2006 Hepatitis B e antigen-negative chronic hepatitis B: natural history and treatment Semin Liver Dis 26 130 141 10.1055/s-2006-939751 (Pubitemid 43668255)
21. JP Zarski P Marcellin M Cohard JM Lutz C Bouche A Rais 1994 Comparison of anti-HBe positive and HBe-antigen-positive chronic hepatitis B in France J Hepatol 20 636 640 10.1016/S0168-8278(05)80352-6 1:STN:280:DyaK2czltFWrsw%3D%3D 8071540
22. GV Papatheodoridis E Dimou K Dimakopoulos S Manolakopoulos I Rapti G Kitis, et al. 2005 Outcome of hepatitis B e antigen-negative chronic hepatitis B on long-term nucleos(t)ide analog therapy starting with lamivudine Hepatology 42 121 129 10.1002/hep.20760 1:CAS:528:DC%2BD2MXms12ntrw%3D 15962291 (Pubitemid 40911319)
23. G Fattovich 2003 Natural history and prognosis of hepatitis B Semin Liver Dis 23 47 58 10.1055/s-2003-37590 12616450
24. MF Yuen E Sablon HJ Yuan CK Hui DK Wong J Doutreloigne, et al. 2002 Relationship between the development of precore and core promoter mutations and hepatitis B e antigen seroconversion in patients with chronic hepatitis B virus J Infect Dis 186 1335 1338 10.1086/344327 1:CAS:528:DC%2BD38XovFKjtbY%3D 12402204 (Pubitemid 35193013)
25. M Lai BJ Hyatt I Nasser M Curry NH Afdhal 2007 The clinical significance of persistently normal ALT in chronic hepatitis B infection J Hepatol 47 760 767 10.1016/j.jhep.2007.07.022 1:CAS:528:DC%2BD2sXht12ns7bI 17928090 (Pubitemid 350051121)
26. M Kumar SK Sarin S Hissar C Pande P Sakhuja BC Sharma, et al. 2008 Virologic and histologic features of chronic hepatitis B virus-infected asymptomatic patients with persistently normal ALT Gastroenterology 134 1376 1384 10.1053/j.gastro.2008.02.075 18471514 (Pubitemid 351615375)
27. HJ Yuan MF Yuen DK Wong E Sablon CL Lai 2005 The relationship between HBV-DNA levels and cirrhosis-related complications in Chinese with chronic hepatitis B J Viral Hepat 12 373 379 10.1111/j.1365-2893.2005.00603.x 15985007 (Pubitemid 40961476)
28. MF Yuen HJ Yuan DK Wong JC Yuen WM Wong AO Chan, et al. 2005 Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications Gut 54 1610 1614 10.1136/gut.2005.065136 15871997 (Pubitemid 41531781)
29. CJ Chu M Hussain AS Lok 2002 Quantitative serum HBV DNA levels during different stages of chronic hepatitis B infection Hepatology 36 1408 1415 1:CAS:528:DC%2BD38Xps1ylurs%3D 12447866
30. MF Yuen 2007 Revisiting the natural history of chronic hepatitis B: impact of new concepts on clinical management J Gastroenterol Hepatol 27 973 976 10.1111/j.1440-1746.2007.04938.x (Pubitemid 47019865)