In vivo MRS assessment of altered fatty acyl unsaturation in liver tumor formation of a TGFα/c-myc transgenic mouse model

Journal of Lipid Research

Volumn 50, Issue 4, 2009, Pages 611-622

  Griffitts, J ^a,b   Tesiram, Y ^a   Reid, G E ^c,d   Saunders, D ^a   Floyd, R A ^a   Towner, Rheal A ^a,b  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

^d Michigan State University   (United States)

Author keywords

Liver cancer; Magnetic resonance spectroscopy; Mice; Tumor lipid metabolism; Unsaturated fatty acids

Indexed keywords

ACYL COENZYME A DESATURASE; ARACHIDONIC ACID; GAMMA LINOLENIC ACID; GLYCEROL PHOSPHATIDYLCHOLINE; LINOLEIC ACID; MYC PROTEIN; OLEIC ACID; PALMITIC ACID; PHOSPHATIDYLCHOLINE; STEAROYL COENZYME A DESATURASE 1; STEAROYL COENZYME A DESATURASE 2; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; FATTY ACID DESATURATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; IN VIVO STUDY; LIVER; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ONCOGENE C MYC; PRECANCER; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; TRANSGENIC MOUSE; TUMOR VOLUME; WESTERN BLOTTING; ANIMAL; CHEMISTRY; DNA MICROARRAY; GENETICS; LIVER TUMOR; METABOLISM; ONCOGENE MYC; PATHOLOGY;

ANIMALS; BLOTTING, WESTERN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FATTY ACIDS, UNSATURATED; GENES, MYC; LIVER NEOPLASMS, EXPERIMENTAL; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICE, TRANSGENIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 67449138979     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M800265-JLR200     Document Type: Article

References (32)

1. World Cancer Report, S. B. W. a.P. Kleihues, Editor. 2003, World Health Organization: Lyon. p. 203-207.
2. Qin, Y., M. Van Cauteren, M. Osteaux, and G. Willems. 1992. Quantitative study of the growth of experimental hepatic tumors in rats by using magnetic resonance imaging. Int. J. Cancer. 51: 665-670.
3. Towner, R. A., H. Hashimoto, and P. M. Summers. 2000. Non-invasive in vivo magnetic resonance imaging assessment of acute aflatoxin B1 hepatotoxicity in rats. Biochim. Biophys. Acta. 1475: 314-320.
4. Abel, S., C. M. Smuts, C. de Villiers, and W. C. A. Gelderblom. 2001. Changes in essential fatty acid patterns associated with normal liver regeneration and the progression of hepatocyte nodules in rat hepatocarcinogenesis. Carcinogenesis. 22: 795-804.
5. Ntambi, J. M., and H. Bene. 2001. Polyunsaturated fatty acid regulation of gene expression. J. Mol. Neurosci. 16: 273-278.
6. Begin, M. E., U. N. Das, G. Ells, and D. F. Horrobin. 1985. Selective killing of human cancer cells by polyunsaturated fatty acids. Prostaglandins Leukot. Med. 19: 177-186.
7. Gelderblom, W. C. A., W. Moritz, S. Swanevelder, C. M. Smuts, and S. Abel. 2002. Lipids and D6-desaturase activity alterations in rat liver microsomal membranes induced by fumonisin B1. Lipids. 37: 869-877.
8. Jiang, W. G., R. P. Bryce, D. F. Horrobin, and R. E. Mansel. 1998. Regulation of tight junction permeability and occludin expression by polyunsaturated fatty acids. Biochem. Biophys. Res. Commun. 244: 414-420.
9. 1H MR spectroscopy. Magn. Reson. Med. 50: 1134-1143.
10. He, Q., R. Z. Xu, P. Shkarin, G. Pizzorno, C. H. Lee-French, D. L. Rothman, D. C. Shungu, and H. Shim. 2003-2004. Magnetic resonance spectroscopic imaging of tumor metabolic markers for cancer diagnosis, metabolic phenotyping, and characterization of tumor microenvironment. Dis. Markers. 19: 69-94.
11. Singer, S., M. Sivaraja, K. Souza, K. Millis, and J. M. Corson. 1996. 1H-NMR detectable fatty acyl chain unsaturation in excised leiomyosarcoma correlate with grade and mitotic activity. J. Clin. Invest. 98: 244-250.
12. Tesiram, Y. A., D. Saunders, and R. A. Towner. 2005. Application of proton NMR spectroscopy in the study of lipid metabolites in a rat hepatocarcinogenesis model. Biochim. Biophys. Acta. 1737: 61-68.
13. Foley, L. M., R. A. Towner, and D. M. Painter. 2001. In vivo image-guided 1H-magnetic resonance spectroscopy of the serial development of hepatocarcinogenesis in an experimental animal model. Biochim. Biophys. Acta. 1526: 230-236.
14. Tesiram, Y. A., D. Saunders, and R. A. Towner. 2008. Chemical speciation by selective heteronuclear single-quantum coherence spectroscopy: determination of double-bond quantity in unsaturated fatty acid compounds. NMR Biomed. 21: 345-356.
15. Kurhanewicz, J., M. G. Swanson, S. J. Nelson, and D. B. Vigneron. 2002. Combined magnetic resonance imaging and spectroscopic imaging approach to molecular imaging of prostate cancer. J. Magn. Reson. Imaging. 16: 451-463.
16. Nelson, S. J., E. Graves, A. Pirzkall, X. Li, A. Antiniw Chan, D. B. Vigneron, and T. R. McKnight. 2002. In vivo molecular imaging for planning radiation therapy of gliomas: an application of 1H MRSI. J. Magn. Reson. Imaging. 16: 464-476.
17. Kaji, Y., A. Wada, I. Imaoka, M. Matsuo, T. Terachi, Y. Kobashi, K. Sugimura, M. Fujii, K. Maruyama, and O. Takizawa. 2002. Proton two-dimensional scemical shift imaging for evaluation of prostate cancer: external surface coil vs. endorectal surface coil. J. Magn. Reson. Imaging. 16: 697-706.
18. Liimatainen, T. 2006. J.H., I. Tkac, O. Grohn, Ultra-short echo time spectroscopic imaging in rats: implications for monitoring lipids in glioma gene therapy. NMR Biomed. 19: 554-559.
19. Fayad, L. M., D. A. Bluemke, E. F. McCarthy, K. L. Weber, P. B. Barker, and M. A. Jacobs. 2006. Musculoskeletal tumors: use of proton MR spectroscopic imaging for characterization. J. Magn. Reson. Imaging. 23: 23-28.
20. Murakami, H., N. D. Sanderson, P. Nagy, P. A. Marino, G. Merlino, and S. S. Thorgeirsson. 1993. Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor α in hepatic oncogenesis. Cancer Res. 53: 1719-1723.
21. Calvisi, D. F., and S. S. Thorgeirsson. 2005. Molecular mechanisms of hepatocarcinogenesis in transgenic mouse models of liver cancer. Toxicol. Pathol. 33: 181-184.
22. Folch, J., M. Lees, and G. H. Sloane-Stanley. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226: 497-509.
23. DeMar, J. C., and R. E. Anderson. 1997. Identification and quantitation of the fatty acids composing the vCoA ester opool of bovine retina, heart, and liver. J. Biol. Chem. 272: 31362-31368.
24. Koivusalo, M., P. Haimi, L. Heikinheimo, R. Kostiainen, and P. Somerharju. 2001. Quantitative determination of phosphlipid compositions by ESI-MS: effets of acyl chain length, unsaturation, and lipid concentration on instrument response. J. Lipid Res. 42: 663-672.
25. Han, X., and R. W. Gross. 2005. Shotgun lipidomics: electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples. Mass Spectrom. Rev. 24: 367-412.
26. Han, X., K. Yang, J. Yang, K. N. Fikes, H. Cheng, and R. W. Gross. 2006. Factors influencing the electrospray intrasource seperation and selective ionization of glycerophospholipids. J. Am. Soc. Mass Spectrom. 17: 264-274.
27. Mitchell, T. W., K. Ekroos, S. J. Blanksby, A. J. Hulbert, and P. L. Else. 2007. Differences in membrane acyl phospholipid composition between an endothermic mammal and an ectothermic reptile are not limited to any phospholipid class. J. Exp. Biol. 210: 3440-3450.
28. Deeley, J. M., T. W. Mitchell, X. Wei, J. Korth, J. R. Nealon, S. J. Blanksby, and R. J. W. Truscott. 2008. Human lens lipids differ markedly from those of commonly used experimental animals. Biochim. Biophys. Acta. 1781: 288-298.
29. Simon, R., E. Korn, L. McShane, M. Radmacher, G. Wright, and Y. Zhao. 2003. Design and Analysis of DNA Microarray Investigations. Springer-Verlag, New York.
30. Korn, E. L., J. F. Troendle, L. M. McShane, and R. Simon. Controlling the number of false discoveries: Application to high-dimensional genomic data. J. Statist. Plann. Inference. In press.
31. Wright, G. W., and R. Simon. 2003. A random variance model for detection of differential gene expression in small microarray experiments. Bioinformatics. 19: 2448-2455.
32. He, Q., P. Shkarin, R. J. Hooley, D. R. Lannin, J. C. Weinreb, and V. I. J. Bossuyt. 2007. In vivo MR spectroscopic imaging of poly-unsaturated fatty acids (PUFA) in healthy and cancerous breast tissues by selective multiple-quantum coherence transfer (Sel-MQC): A preliminary study. Magn. Reson. Med. 58: 1079-1085.