Phosphatidylserine exposure and other apoptotic-like events in Bernard-Soulier syndrome platelets

American Journal of Hematology

Volumn 85, Issue 8, 2010, Pages 584-592

  Rand, Margaret L ^a,b   Wang, Hong ^a   Bang, K W Annie ^c   Teitel, Jerome M ^b,c   Blanchette, Victor S ^a,d   Freedman, John ^b,c   Nurden, Alan T ^e  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c ST MICHAEL'S HOSPITAL   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e Ctr Geriatrie Ctr Hosp Univ B   (France)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; LIPOCORTIN 5; PHOSPHATIDYLSERINE; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 4; THROMBIN; ADHESION RECEPTOR; MEMBRANE LIPID; MEMBRANE PROTEIN; OLIGOPEPTIDE; PAR 1 ACTIVATING PEPTIDE; PAR-1-ACTIVATING PEPTIDE; PROTEASE-ACTIVATED RECEPTOR 4; THROMBIN RECEPTOR;

ADULT; APOPTOSIS; ARTICLE; BERNARD SOULIER DISEASE; BLOOD; CASE REPORT; CELL LOSS; CELL SURVIVAL; CHILD; FLOW CYTOMETRY; HUMAN; MALE; MEMBRANE POTENTIAL; MITOCHONDRION; PLATELET MICROPARTICLE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; THROMBOCYTE; ADOLESCENT; BIOSYNTHESIS; CELL SIZE; CHEMISTRY; DRUG EFFECT; GENETICS; PATHOLOGY; THROMBOCYTE ACTIVATION; THROMBOCYTE COUNT;

ADOLESCENT; APOPTOSIS; BERNARD-SOULIER SYNDROME; BLOOD PLATELETS; CELL SIZE; CHILD; COLLAGEN; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE LIPIDS; OLIGOPEPTIDES; PHOSPHATIDYLSERINES; PLATELET ACTIVATION; PLATELET COUNT; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; RECEPTOR, PAR-1; RECEPTORS, THROMBIN;

EID: 77955504290     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.21768     Document Type: Article

References (64)

1. Nurden AT, George JN. Inherited abnormalities of the platelet membrane: Glanzmann thrombasthenia, Bernard-Soulier syndrome, and other disorders. In: Colman RW, Marder VJ, Clowes AW, George JN, Goldhaber SZ, editors. Hemostasis and Thrombosis, 5th ed. Philadelphia: Lippincott, Williams & Wilkins; 2006. pp 987-1010.
2. Nurden AT, Nurden P. Inherited disorders of platelet function. In: Michelson AD, editor. Platelets, 2nd ed. San Diego: Academic Press; 2007. pp 1025-1050.
3. Perret B, Levy-Toledano S, Bredoux R, et al. Abnormal phospholipid organization in Bernard-Soulier platelets. Thromb Res 1983;31:529-537.
4. Zwaal RF, Schroit AJ. Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood 1997;89:1121-1132.
5. Dachary-Prigent J, Freyssinet JM, Pasquet JM, et al. Annexin V as a probe of aminophospholipid exposure and platelet membrane vesiculation: A flow cytometry study showing a role for free sulfhydryl groups. Blood 1993;81:2554-2565.
6. Wolfs JL, Comfurius P, Rasmussen JT, et al. Activated scramblase and inhibited aminophospholipid translocase cause phosphatidylserine exposure in a distinct platelet fraction. Cell Mol Life Sci 2005;62:1514-1525.
7. Heemskerk JW, Bevers EM, Lindhout T. Platelet activation and blood coagulation. Thromb Haemost 2002;88:186-193.
8. Zwaal RF, Comfurius P, Bevers EM. Surface exposure of phosphatidylserine in pathological cells. Cell Mol Life Sci 2005;62:971-988.
9. Fadok VA, Voelker DR, Campbell PA, et al. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol 1992;148:2207-2216.
10. Granville DJ, Carthy CM, Hunt DW, McManus BM. Apoptosis: Molecular aspects of cell death and disease. Lab Invest 1998;78:893-913.
11. Leytin V, Freedman J. Platelet apoptosis in stored platelet concentrates and other models. Transfus Apher Sci 2003;28:285-295.
12. Rand ML, Wang H, Bang KW, et al. Procoagulant surface exposure and apoptosis in rabbit platelets: Association with shortened survival and steady-state senescence. J Thromb Haemost 2004;2:651-659.
13. Leung R, Gwozdz AM, Wang H, et al. Persistence of procoagulant surface expression on activated human platelets: Involvement of apoptosis and aminophospholipid translocase activity. J Thromb Haemost 2007;5:560-570.
14. Leytin V, Allen DJ, Mykhaylov S, et al. Thrombin-triggered platelet apoptosis. J Thromb Haemost 2006;4:2656-2663.
15. Jobe SM, Wilson KM, Leo L, et al. Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis. Blood 2008;111:1257-1265.
16. Schoenwaelder SM, Yuan Y, Josefsson EC, et al. Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function. Blood 2009;114:663-666.
17. Bevers EM, Comfurius P, Zwaal RF. Changes in membrane phospholipid distribution during platelet activation. Biochim Biophys Acta 1983;736:57-66.
18. McNicol A, Sutherland M, Zou R, Drouin J. Defective thrombin-induced calcium changes and aggregation of Bernard-Soulier platelets are not associated with deficient moderate-affinity receptors. Arterioscler Thromb Vasc Biol 1996;16:628-632.
19. Perez-Pujol S, Lozano M, Escolar G, et al. Glycoproteins expression on platelet membrane in inherited macrothrombocytopenias. Thromb Res 2003;112:233-237.
20. Diaz-Ricart M, Fuste B, Estebanell E, et al. Efficient tyrosine phosphorylation of proteins after activation of platelets with thrombin depends on intact glycoprotein Ib. Platelets 2005;16:453-461.
21. Vanhoorelbeke K, Schlammadinger A, Delville JP, et al. Occurrence of the Asn45Ser mutation in the GPIX gene in a Belgian patient with Bernard Soulier syndrome. Platelets 2001;12:114-120.
22. Wright JF, Wang H, Hornstein A, et al. Characterization of platelet glycoproteins and platelet/endothelial cell antibodies in patients with thrombotic thrombocytopenic purpura. Br J Haematol 1999;107:546-555.
23. Mody M, Lazarus AH, Semple JW, Freedman J. Preanalytical requirements for flow cytometric evaluation of platelet activation: Choice of anticoagulant. Transfus Med 1999;9:147-154.
24. Nurden AT, Breillat C, Jacquelin B, et al. Triple heterozygosity in the integrin alphaIIb subunit in a patient with Glanzmann's thrombasthenia. J Thromb Haemostas 2004;2:813-819.
25. Simsek S, Noris P, Lozano M, et al. Cys209 Ser mutation in the platelet membrane glycoprotein Ib alpha gene is associated with Bernard-Soulier syndrome. Br J Haematol 1994;88:839-844.
26. Sachs UJ, Kroll H, Matzdorff AC, et al. Bernard-Soulier syndrome due to the homozygous Asn-45Ser mutation in GPIX: An unexpected, frequent finding in Germany. Br J Haematol 2003;123:127-131.
27. Laudano AP, Doolittle RF. Synthetic peptide derivatives that bind to fibrinogen and prevent the polymerization of fibrin monomers. Proc Natl Acad Sci U S A 1978;75:3085-3089.
28. Plow EF, Marguerie G. Inhibition of fibrinogen binding to human platelets by the tetrapeptide glycyl-L-prolyl-L-arginyl-L-proline. Proc Natl Acad Sci U S A 1982;79:3711-3715.
29. Michelson AD. Platelet activation by thrombin can be directly measured in whole blood through the use of the peptide GPRP and flow cytometry: Methods and clinical applications. Blood Coagul Fibrinolysis 1994;5:121-131.
30. Rand ML, Wang H, Bang KW, et al. Rapid clearance of procoagulant platelet-derived microparticles from the circulation of rabbits. J Thromb Haemost 2006;4:1621-1623.
31. Leytin V, Allen DJ, Mutlu A, et al. Mitochondrial control of platelet apoptosis: Effect of cyclosporin A, an inhibitor of the mitochondrial permeability transition pore. Lab Invest 2009;89:374-384.
32. Rukoyatkina N, Begonja AJ, Geiger J, et al. Phosphatidylserine surface expression and integrin alpha IIb beta 3 activity on thrombin/convulxin stimulated platelets/particles of different sizes. Br J Haematol 2009;144:591-602.
33. Frojmovic M, Wong T. Dynamic measurements of the platelet membrane glycoprotein IIb-IIIa receptor for fibrinogen by flow cytometry. II. Platelet size-dependent subpopulations. Biophys J 1991;59:828-837.
34. Shapiro HM. Parameters and probes. In: Shapiro HM, editor. Practical Flow Cytometry, 4th ed. Hoboken, NJ: John Wiley & Sons; 2003. pp 273-410.
35. Aster RH, Jandl JH. Platelet sequestration in man. I. Methods. J Clin Invest 1964;43:843-855.
36. Harper MT, Sage SO. Actin polymerisation regulates thrombin-evoked Ca(21) signalling after activation of PAR-4 but not PAR-1 in human platelets. Platelets 2006;17:134-142.
37. Hourdille P, Pico M, Jandrot-Perrus M, et al. Studies on the megakaryocytes of a patient with the Bernard-Soulier syndrome. Br J Haematol 1990;76:521-530.
38. Wright SD, Michaelides K, Johnson DJ, et al. Double heterozygosity for mutations in the platelet glycoprotein IX gene in three siblings with Bernard-Soulier syndrome. Blood 1993;81:2339-2347.
39. Clemetson JM, Kyrle PA, Brenner B, Clemetson KJ. Variant Bernard-Soulier syndrome associated with a homozygous mutation in the leucine-rich domain of glycoprotein IX. Blood 1994;84:1124-1131.
40. Donner M, Karpman D, Kristoffersson AC, et al. Recurrent mutation Asn45 - >Ser of glycoprotein IX in Bernard-Soulier syndrome. Eur J Haematol 1996; 57:178-179.
41. Koskela S, Javela K, Jouppila J, et al. Variant Bernard-Soulier syndrome due to homozygous Asn45Ser mutation in the platelet glycoprotein (GP) IX in seven patients of five unrelated Finnish families. Eur J Haematol 1999;62: 256-264.
42. Liang HP, Morel-Kopp MC, Clemetson JM, et al. A common ancestral glycoprotein (GP) 9 1828A>G (Asn45Ser) gene mutation occurring in European families from Australia and Northern Europe with Bernard-Soulier Syndrome (BSS). Thromb Haemost 2005;94:599-605.
43. Dagistan N, Kunishima S. First Turkish case of Bernard-Soulier syndrome associated with GPIX N45S. Acta Haematol 2007;118:146-148.
44. Zieger B, Jenny A, Tsakiris DA, et al. A large Swiss family with Bernard-Soulier syndrome - Correlation phenotype and genotype. Hamostaseologie 2009; 29:161-167.
45. Malmsten C, Kindahl H, Samuelsson B, et al. Thromboxane synthesis and the platelet release reaction in Bernard-Soulier syndrome, thrombasthenia Glanzmann and Hermansky-Pudlak syndrome. Br J Haematol 1977;35:511-520.
46. Jandrot-Perrus M, Rendu F, Caen JP, et al. The common pathway for alpha- and gamma-thrombin-induced platelet activation is independent of GPIb: A study of Bernard-Soulier platelets. Br J Haematol 1990;75:385-392.
47. Andersen H, Greenberg DL, Fujikawa K, et al. Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity. Proc Natl Acad Sci U S A 1999;96:11189-11193.
48. Bevers EM, Comfurius P, Nieuwenhuis HK, et al. Platelet prothrombin converting activity in hereditary disorders of platelet function. Br J Haematol 1986;63:335-345.
49. Caen J, Bellucci S. The defective prothrombin consumption in Bernard- Soulier syndrome. Hypotheses from 1948 to 1982. Blood Cells 1983;9:389-399.
50. Bellucci S, Girma JP, Lozano M, et al. Impaired prothrombin consumption in Bernard-Soulier syndrome is corrected in vitro by human factor VIII. Thromb Haemost 1997;77:383-386.
51. Beguin S, Keularts I, Al Dieri R, et al. Fibrin polymerization is crucial for thrombin generation in platelet-rich plasma in a VWF-GPIb-dependent process, defective in Bernard-Soulier syndrome. J Thromb Haemost 2004;2:170-176.
52. Weiss HJ. Impaired platelet procoagulant mechanisms in patients with bleeding disorders. Semin Thromb Hemost 2009;35:233-241.
53. Walsh PN. Platelet coagulation-protein interactions. Semin Thromb Hemost 2004;30:461-471.
54. Dormann D, Clemetson KJ, Kehrel BE. The GPIb thrombin-binding site is essential for thrombin-induced platelet procoagulant activity. Blood 2000;96:2469-2478.
55. Dachary-Prigent J, Pasquet JM, Freyssinet JM, Nurden AT. Calcium involvement in aminophospholipid exposure and microparticle formation during platelet activation: A study using Ca21-ATPase inhibitors. Biochemistry 1995;34:11625-11634.
56. Dachary-Prigent J, Pasquet JM, Nurden AT. Simultaneous detection of changes in cytoplasmic Ca(21), aminophospholipid exposure and microvesiculation in activated platelets. Platelets 1997;8:405-412.
57. Rand ML, Wang H, Bang KW, Freedman J. Do young platelets have an enhanced capacity to expose procoagulant phosphatidylserine (PS) upon activation? J Thromb Haemost 2009;7 (Suppl 2):Abstract PP-MO-020.
58. Augereau O, Rossignol R, DeGiorgi F, et al. Apoptotic-like mitochondrial events associated to phosphatidylserine exposure in blood platelets induced by local anaesthetics. Thromb Haemost 2004;92:104-113.
59. Leytin V, Allen DJ, Mykhaylov S, et al. Pathologic high shear stress induces apoptosis events in human platelets. Biochem Biophys Res Commun 2004;320:303-310.
60. Remenyi G, Szasz R, Friese P, Dale GL. Role of mitochondrial permeability transition pore in coated-platelet formation. Arterioscler Thromb Vasc Biol 2005;25:467-471.
61. Najean Y, Ardaillou N, Caen J, et al. Survival of Radiochromium-Labeled Platelets in Thrombocytopenias. Blood 1963;22:718-732.
62. Tomer A, Scharf RE, McMillan R, et al. Bernard-Soulier syndrome: Quantitative characterization of megakaryocytes and platelets by flow cytometric and platelet kinetic measurements. Eur J Haematol 1994;52:193-200.
63. Heyns Adu P, Badenhorst PN, Wessels P, et al. Kinetics, in vivo redistribution and sites of sequestration of indium-111-labelled platelets in giant platelet syndromes. Br J Haematol 1985;60:323-330.
64. Sorensen AL, Rumjantseva V, Nayeb-Hashemi S, et al. Role of sialic acid for platelet life span: Exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes. Blood 2009;114:1645-1654.