Further exploration of the possible influence of polymorphisms in HTR2C and 5HTT on body weight

Metabolism: Clinical and Experimental

Volumn 59, Issue 8, 2010, Pages 1156-1163

  Bah, Jessica ^a   Westberg, Lars ^a   Baghaei, Fariba ^b   Henningsson, Susanne ^a   Rosmond, Roland ^b   Melke, Jonas ^a   Holm, Göran ^b   Eriksson, Elias ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; SERINE; SEROTONIN; SEROTONIN 2C RECEPTOR; SEROTONIN TRANSPORTER; THREONINE;

ADULT; ALLELE; ARTICLE; BODY MASS; BODY WEIGHT; COHORT ANALYSIS; FEMALE; GENOTYPE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; UNDERWEIGHT; GENETIC POLYMORPHISM; GENETICS;

ADULT; BODY MASS INDEX; BODY WEIGHT; FEMALE; GENOTYPE; HUMANS; MALE; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; RECEPTOR, SEROTONIN, 5-HT2C; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 77955502690     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2009.11.007     Document Type: Article

References (35)

1. Marston O.J., and Heisler L.K. Targeting the serotonin 2C receptor for the treatment of obesity and type 2 diabetes Neuropsychopharmacol 34 2009 252 253
2. Berg K.A., Clarke W.P., Cunningham K.A., and Spampinato U. Fine-tuning serotonin 2C receptor function in the brain: molecular and functional implications Neuropharmacol 55 2008 969 976
3. Werry T.D., Loiacono R., Sexton P.M., and Christopoulos A. RNA editing of the serotonin 5HT23C receptor and its effects on cell signalling, pharmacology and brain function. Pharmacol Ther 119 2008 7 23
4. Kennett G.A., and Curzon G. Potencies of antagonists indicate that 5-HT1C receptors mediate 1-3(chlorophenyl)piperazine-induced hypophagia Br J Pharmacol 103 1991 2016 2020
5. Tecott L.H., Sun L.M., Akana S.F., Strack A.M., Lowenstein D.H., and Dallman M.F. Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors Nature 374 1995 542 546
6. Reynolds G.P., Hill M.J., and Kirk S.L. The 5-HT2C receptor and antipsychotic-induced weight gain-mechanisms and genetics J Psychopharmacol 20 2006 15 18
7. Cowen P.J., Clifford E.M., Walsh A.E., Williams C., and Fairburn C.G. Moderate dieting causes 5-HT2C receptor supersensitivity Psychol Med 26 1996 1155 1159
8. Lappalainen J., Zhang L., Dean M., Oz M., Ozaki N., and Yu D.H. Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C) Genomics 27 1995 274 279
9. Yuan X., Yamada K., Ishiyama-Shigemoto S., Koyama W., and Nonaka K. Identification of polymorphic loci in the promoter region of the serotonin 5-HT2C receptor gene and their association with obesity and type II diabetes Diabetologia 43 2000 373 376
10. Fentress H.M., Grinde E., Mazurkiewicz J.E., Backstrom J.R., Herrick-Davis K., and Sanders-Bush E. Pharmacological properties of the Cys23Ser single nucleotide polymorphism in human 5-HT2C receptor isoforms Pharmacogenomics J 5 2005 244 254
11. Okada M., Northup J.K., Ozaki N., Russell J.T., Linnoila M., and Goldman D. Modification of human 5-HT(2C) receptor function by Cys23Ser, an abundant, naturally occurring amino-acid substitution Mol Psychiatry 9 2004 55 64
12. Kuhn K.U., Joe A.Y., Meyer K., Reichmann K., Maier W., and Rao M.L. Neuroimaging and 5-HT2C receptor polymorphism: a HMPAO-SPECT study in healthy male probands using mCPP-challenge of the 5-HT2C receptor Pharmacopsychiatry 37 2004 286 291
13. Westberg L., Bah J., Rastam M., Gillberg C., Wentz E., and Melke J. Association between a polymorphism of the 5-HT2C receptor and weight loss in teenage girls Neuropsychopharmacology 26 2002 789 793
14. Hu X., Giotakis O., Li T., Karwautz A., Treasure J., and Collier D.A. Association of the 5-HT2c gene with susceptibility and minimum body mass index in anorexia nervosa Neuroreport 14 2003 781 783
15. Praschak-Rieder N., Willeit M., Zill P., Winkler D., Thierry N., and Konstantinidis A. A Cys 23-Ser 23 substitution in the 5-HT(2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative study J Psychiatr Res 39 2005 561 567
16. Lentes K.U., Hinney A., Ziegler A., Rosenkranz K., Wurmser H., and Barth N. Evaluation of a Cys23Ser mutation within the human 5-HT2C receptor gene: no evidence for an association of the mutant allele with obesity or underweight in children, adolescents and young adults Life Sci 61 1997 PL9 PL16
17. Hill M.J., and Reynolds G.P. 5-HT2C receptor gene polymorphisms associated with antipsychotic drug action alter promoter activity Brain Res 1149 2007 14 17
18. McCarthy S., Mottagui-Tabar S., Mizuno Y., Sennblad B., Hoffstedt J., and Arner P. Complex HTR2C linkage disequilibrium and promoter associations with body mass index and serum leptin Hum Genet 117 2005 545 557
19. Buckland P.R., Hoogendoorn B., Guy C.A., Smith S.K., Coleman S.L., and O'Donovan M.C. Low gene expression conferred by association of an allele of the 5-HT2C receptor gene with antipsychotic-induced weight gain Am J Psychiatry 162 2005 613 615
20. Reynolds G.P., Zhang Z.J., and Zhang X.B. Association of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism Lancet 359 2002 2086 2087
21. Pooley E.C., Fairburn C.G., Cooper Z., Sodhi M.S., Cowen P.J., and Harrison P.J. A 5-HT2C receptor promoter polymorphism (HTR2C -759C/T) is associated with obesity in women, and with resistance to weight loss in heterozygotes Am J Med Genet B Neuropsychiatr Genet 126 2004 124 127
22. Bozina N., Medved V., Kuzman M.R., Sain I., and Sertic J. Association study of olanzapine-induced weight gain and therapeutic response with SERT gene polymorphisms in female schizophrenic patients J Psychopharmacol 21 2007 728 734
23. Hoffman J.B., Kaplan J.R., Kinkead B., Berga S.L., and Wilson M.E. Metabolic and reproductive consequences of the serotonin transporter promoter polymorphism (5-HTTLPR) in adult female rhesus monkeys (Macaca mulatta) Endocrine 31 2007 202 211
24. Matsushita S., Suzuki K., Murayama M., Nishiguchi N., Hishimoto A., and Takeda A. Serotonin transporter regulatory region polymorphism is associated with anorexia nervosa Am J Med Genet B Neuropsychiatr Genet 128 2004 114 117
25. Mergen H., Karaaslan C., Mergen M., Deniz Ozsoy E., and Ozata M. ALEPR, ADBR3, IRS-1 and 5-HTT genes polymorphisms do not associate with obesity Endocr J 54 2007 89 94
26. Sookoian S., Gemma C., Garcia S.I., Fernandez Gianotti T., Dieuzeide G., and Roussos A. Short allele of serotonin transporter gene promoter is a risk factor for obesity in adolescents Obesity (Silver Spring) 15 2007 271 276
27. Rosmond R., and Bjorntorp P. Psychiatric ill-health of women and its relationship to obesity and body fat distribution Obes Res 6 1998 338 345
28. Rosmond R., Dallman M.F., and Bjorntorp P. Stress-related cortisol secretion in men: relationships with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities J Clin Endocrinol Metab 83 1998 1853 1859
29. Monteleone P., Tortorella A., Castaldo E., and Maj M. Association of a functional serotonin transporter gene polymorphism with binge eating disorder Am J Med Genet B Neuropsychiatr Genet 141 2006 7 9
30. Di Bella D.D., Catalano M., Cavallini M.C., Riboldi C., and Bellodi L. Serotonin transporter linked polymorphic region in anorexia nervosa and bulimia nervosa Mol Psychiatry 5 2000 May 233 234
31. Hinney A., Barth N., Ziegler A., von Prittwitz S., Hamann A., and Hennighausen K. Serotonin transporter gene-linked polymorphic region: allele distributions in relationship to body weight and in anorexia nervosa Life Sci 61 1997 PL295 PL303
32. Ebstein R.P., Segman R., Benjamin J., Osher Y., Nemanov L., and Belmaker R.H. 5-HT2C (HTR2C) serotonin receptor gene polymorphism associated with the human personality trait of reward dependence: interaction with dopamine D4 receptor (D4DR) and dopamine D3 receptor (D3DR) polymorphisms Am J Med Genet 74 1997 65 72
33. Evans J., Reeves B., Platt H., Leibenau A., Goldman D., Jefferson K., and Nutt D Impulsiveness, serotonin genes and repetition of deliberate self-harm (DSH) Psychol Med 30 2000 1327 1334
34. Tochigi M., Hibino H., Otowa T., Ohtani T., Ebisawa T., Kato N., and Sasaki T. No association of 5-HT2C, 5-HT6, and tryptophan hydroxylase-1 gene polymorphisms with personality traits in the Japanese population Neurosci Lett 403 2006 100 102 (Pubitemid 43963236)
35. Serretti A, Mandelli L, Giegling I, Schneider B, Hartmann AM, Schnabel A, Maurer K, Möller HJ, Rujescu D. HTR2C and HTR1A gene variants in German and Italian suicide attempters and completers. Am J Med Genet B Neuropsychiatr Genet.;144B:291-9.