Multi-step evolution of protein conformation on electrospray into the gas phase

European Journal of Mass Spectrometry

Volumn 16, Issue 3, 2010, Pages 437-442

  McLafferty, Fred W ^a   Castro, Sergio ^a   Breuker, Kathrin ^b  

^a Department of Obstetrics Gynecology   (United States)

^b UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Electrospray; Gaseous protein conformation; H D exchange; Protein folding

Indexed keywords

GASES; PROTEIN FOLDING;

DENATURED PROTEINS; ELECTROSPRAYS; EXPERIMENTAL METHODS; H/D EXCHANGE; MULTI-STEP EVOLUTIONS; NON-NATIVE; PROTEIN CONFORMATION; SIDE-CHAINS;

PROTEINS;

DEUTERIUM; HYDROGEN; PROTEIN; UBIQUITIN; WATER;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; GAS; METHODOLOGY; PROTEIN CONFORMATION;

DEUTERIUM; GASES; HYDROGEN; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; UBIQUITIN; WATER;

EID: 77955500183     PISSN: 14690667     EISSN: None     Source Type: Journal    
DOI: 10.1255/ejms.1058     Document Type: Conference Paper

References (32)

1. J.B. fenn, M. Mann, c.K. Meng, S.f. Wong and M. Whitehouse, "Electrospray ionization for mass spectrometry of large biomolecules", Science 246, 64 (1989). doi: 10.1126/science.2675315
2. B. Ganem, y.t. Li and J.D. Henion, "Detection of noncovalent receptor-ligand complexes by mass spectrometry", J. Am. Chem. Soc. 113, 6294 (1991). doi: 10.1021/ja00016a069
3. V. Katta and B.t. chait, "observation of the heme-globin complex in native myoglobin by electrospray ionization mass spectrometry", J. Am. Chem. Soc. 113, 8534 (1991). doi: 10.1021/ja00071a058
4. y.t. Li, y.L. Hsieh, J.D. Henion, M.W. Senko, f.W. McLafferty and B. Ganem, "Mass spectrometric studies on noncovalent dimers of leucine zipper peptides", J. Am. Chem. Soc. 115, 8409 (1993). doi: 10.1021/ja00071a058
5. V. Gabelica and E. De Pauw, "Internal energy and fragmentation of ions produced in electrospray sources", Mass Spectrom. Rev. 24, 566 (2005). doi: 10.1002/mas.20027 (Pubitemid 41083802)
6. S.A. Hofstadler and K.A. Sannes-Lowery, "Applications of ESI-MS in drug discovery: Interrogation of noncovalent complexes", Nat. Rev. Drug Discovery 5, 585 (2006). doi: 10.1038/nrd2083 (Pubitemid 43971193)
7. A.J.Heck and H.H. van den Heuvel, "Investigation of intact protein complexes by mass spectrometry", Mass Spectrom. Rev. 23, 368 (2004). doi: 10.1002/mas.10081
8. M. Zhou, A.M. Sandercock, c.S. fraser, G. ridlova, E. Stephens, M.r. Schenauer, t. yokoi-fong, D. Barsky, J.A. Leary, J.W. Hershey, J.A. Doudna and V. robinson, "Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIf3", Proc. Natl. Acad. Sci. USA 105, 18139 (2008). doi: 10.1073/pnas.0801313105
9. X. Han, M. Jin, K. Breuker and f.W. McLafferty, "Extending top-down mass spectrometry to proteins with masses > 200 kDa", Science 314, 109 (2006). doi: 10.1126/science.1128868 (Pubitemid 44547751)
10. N.L. Kelleher, H.y. Lin, G.A. Valaskovic, D.J. Aaserud, E.K. fridriksson and W. McLafferty, "top down versus bottom up protein characterization by tandem high-resolution mass spectrometry", J. Am. Chem. Soc. 121, 806 (1999). doi: 10.1021/ja973655h (Pubitemid 29077299)
11. S.K. chowdhury, V. Katta and B.t. chait, "Probing conformational changes in proteins by mass spectrometry", J. Am. Chem. Soc. 112, 9012 (1990). doi: 10.1021/ja00180a074
12. V. Katta and B."conformational changes in proteins probed by hydrogen-exchange electrospray-ionization mass spectrometry", Rapid Comm. Mass Spectrom. 5, 214 (1991). doi: 10.1002/rcm.1290050415
13. D. Suckau, y. Shi, S.c. Beu, M.W. Senko, J.P. Quinn, f.M. Wampler, III and W. McLafferty, "coexisting stable conformations of gaseous protein ions", Proc. Natl. Acad. Sci. USA 90, 790 (1993). doi: 10.1073/pnas.90.3. 790 (Pubitemid 23053895)
14. M.A. freitas, c.L. Hendrickson, M.r. Emmett and A.G. Marshall, "Gas-phase bovine ubiquitin cation conformations resolved by gas-phase hydrogen/deuterium exchange rate and extent", Int. J. Mass Spectrom. 185-187, 565 (1999). doi: 10.1016/S1387-3806(98)14172-6
15. H.B. oh, K. Breuker, S.K. Sze, y. Ge, B.K. carpenter and F.W. McLafferty, "Secondary and tertiary structures of gaseous protein ions characterized by electron capture dissociation mass spectrometry and photofragment spectroscopy", Proc. Natl. Acad. Sci. USA 99, 15863 (2002). doi: 10.1073/pnas.212643599 (Pubitemid 35462713)
16. f.W. McLafferty, Z. Guan, u. Haupts, t.D. Wood and N.L. Kelleher, "Gaseous conformational structures of cytochrome c", J. Am. Chem. Soc. 120, 4732 (1998). doi: 10.1021/ja9728076 (Pubitemid 28282726)
17. S.J. Valentine, A.E. counterman and D.E. clemmer, "Conformer- dependent proton transfer reactions of ubiquitin ions", J. Am. Soc. Mass Spectrom. 8, 954 (1997). doi: 10.1016/S1044-0305(97)00085-8 (Pubitemid 27375490)
18. c.S. Hoaglund, S.J. Valentine, c.r. Sporleder, J.P. reilly and D.E. "three-dimensional ion mobility/tofMS analysis of electrosprayed biomolecules", Anal. Chem. 70, 2236 (1998). doi: 10.1021/ac980059c
19. K. Breuker, H.B. oh, D.M. Horn, B.A. cerda and f.W. McLafferty, "Detailed unfolding and folding of gaseous ubiquitin ions characterized by electron capture dissociation", J. Am. Chem. Soc. 124, 6407 (2002). doi: 10.1021/ja012267j (Pubitemid 34580585)
20. J. Li, J.A. taraszka, A.E. counterman and D.E. Clemmer, "Influence of solvent composition and capillary temperature on the conformations of electrosprayed ions: unfolding of compact ubiquitin conformers from pseudonative and denatured solutions", Int. J. Mass Spectrom. 185-187, 37 (1999). doi: 10.1016/S1387-3806(98)14135-0
21. E.r. Badman, S. Myung and D.E. clemmer, "Evidence for unfolding and refolding of gas-phase cytochrome c ions in a Paul trap", J. Am. Soc. Mass Spectrom. 16, 1493 (2005). doi: 10.1016/j.jasms.2005.04.013 (Pubitemid 41169858)
22. K. Breuker, W. McLafferty, "Step-wise evolution of protein native structure with electrospray into the gas phase, 10-12-102 s", Proc. Natl. Acad. Sci. USA 105, 18145 (2008). doi: 10.1073/pnas.0807005105
23. M.Z. Steinberg, r. Elber, f.W. McLafferty, B. Gerber and K. Breuker, "Early structural evolution of native Cytochrome c after solvent removal", ChemBioChem 9, 2417 (2008). doi: 10.1002/cbic.200800167
24. r.A. Zubarev, D.M. Horn, E.K. fridriksson, N.L. Kelleher, N.A. Kruger, M.A. Lewis, B.K. carpenter and f.W. McLafferty, "Electron capture dissociation for structural characterization of multiply charged protein cations", Anal. Chem. 72, 563 (2000). doi: 10.1021/ac990811p (Pubitemid 33595293)
25. D.M. Horn, K. Breuker, A.J. frank and W. McLafferty, "Kinetic intermediates in the folding of gaseous protein ions characterized by electron capture dissociation mass spectrometry", J. Am. Chem. Soc. 123, 9792 (2001). doi: 10.1021/ja003143u (Pubitemid 32929383)
26. K. Breuker and f.W. McLafferty, "Native electron capture dissociation for the structural characterization of noncovalent interactions in native cytochrome c", Angew. Chem., Int. Ed. 42, 4900 (2003). doi: 10.1002/anie.200351705 (Pubitemid 37345386)
27. K. Breuker and W. McLafferty, "the thermal unfolding of native cytochrome c in the transition from solution to gas phase probed by native electron capture dissociation", Angew. Chem., Int. Ed. 44, 4911 (2005). doi: 10.1002/anie.200500668 (Pubitemid 41138677)
28. J.c. Jurchen and E.r. Williams, "origin of asymmetric charge partitioning in the dissociation of gas-phase protein homodimers", J. Am. Chem. Soc. 125, 2817 (2003). doi: 10.1021/ja0211508 (Pubitemid 36512268)
29. N.L. Kelleher, S.V. taylor, D. Grannis, c. Kinsland, H.J. chiu, t.P. Begley and f.W. McLafferty, "Efficient sequence analysis of the six gene products (7-74 kDa) from the escherichia coli thiamin biosynthetic operon by tandem high-resolution mass spectrometry", Protein Sci. 7, 1796 (1998). doi: 10.1002/pro.5560070815
30. X. Kong, S. castro, K. Breuker and W. McLafferty, Proceedings, 57th ASMS Conference on Mass Spectrometry, Philadelphia, PA, uSA, (2009).
31. E. Shakhnovich, "Protein folding roller coaster, one molecule at a time", Proc. Natl. Acad. Sci. 106, 11823 (2009). doi: 10.1073/pnas. 0906228106
32. H. chung, J. Lewis and W. Eaton, "Experimental determination of upper bound for transition path times in protein folding from sinle-molecule photon-by-photon trajectories", Proc. Natl. Acad. Sci. USA 106, 11837 (2009). doi: 10.1073/pnas.0901178106