Design, synthesis, and biological evaluation of prenylated chalcones as 5-LOX inhibitors

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 16, 2010, Pages 5807-5815

  Reddy, Nimmanapalli P ^a   Aparoy, Polamarasetty ^a   Reddy, T Chandra Mohan ^a   Achari, Chandrani ^a   Sridhar, P Ramu ^a   Reddanna, Pallu ^a  

^a UNIVERSITY OF HYDERABAD   (India)

Author keywords

5 LOX; Anti proliferative; Claisen Schmidt condensation reaction; Docking; LUDI; Prenylated chalcone

Indexed keywords

2' HYDROXY 2,3 DIMETHOXY 4' O PRENYLCHALCONE; 2' HYDROXY 2,3,4 TRIMETHOXY 4' O PRENYLCHALCONE; 2' HYDROXY 3,4 DIMETHOXY 4' O PRENYLCHALCONE; 2' HYDROXY 3,4,5 TRIMETHOXY 4' O PRENYLCHALCONE; 2' HYDROXY 4 METHOXY 4' O PRENYLCHALCONE; 2,3 DIMETHOXY 2',4' DI O PRENYLCHALCONE; 2,3,4 TRIMETHOXY 2',4' O PRENYLCHALCONE; 3,4 DIMETHOXY 2',4' DI O PRENYLCHALCONE; 3,4,5 TRIMETHOXY 2',4', DI O PRENYLCHALCONE; 4 METHOXY 2', 4' DI O PRENYLCHALCONE; CHALCONE DERIVATIVE; LIPOXYGENASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CLAISEN CONDENSATION; CONTROLLED STUDY; DRUG BINDING; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; EVALUATION; FEMALE; HUMAN; HUMAN CELL; IC 50; MOLECULAR MODEL;

ARACHIDONATE 5-LIPOXYGENASE; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CHALCONES; COLONIC NEOPLASMS; HUMANS; LIPOXYGENASE INHIBITORS; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955473114     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.06.107     Document Type: Article

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