Evaluation of 99mTechnetium-mebrofenin and 99mTechnetium-sestamibi as specific probes for hepatic transport protein function in rat and human hepatocytes

Pharmaceutical Research

Volumn 27, Issue 9, 2010, Pages 1987-1998

  Swift, Brandon ^a   Yue, Wei ^a   Brouwer, Kim L R ^a  

^a University of North Carolina   (United States)

Author keywords

99mTechnetium mebrofenin; 99mTechnetium sestamibi; hepatic basolateral efflux; hepatic canalicular efflux; sandwich cultured hepatocytes

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; CLONIDINE; DESIPRAMINE; GLYCYRRHIZIC ACID; KETOPROFEN; MEBROFENIN TC 99M; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; MULTIDRUG RESISTANCE PROTEIN 2; RIFAMYCIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BILE LEVEL; DRUG EXCRETION; DRUG UPTAKE; HEPATOBILIARY SYSTEM; HUMAN; HUMAN CELL; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TRANSPORT; RAT;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CARRIER PROTEINS; CELLS, CULTURED; FEMALE; HEPATOCYTES; HUMANS; IMINO ACIDS; LIVER; MALE; MIDDLE AGED; NEOPLASM PROTEINS; ORGANIC ANION TRANSPORTERS; ORGANOTECHNETIUM COMPOUNDS; RATS; RATS, WISTAR; RIFAMYCINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TECHNETIUM TC 99M SESTAMIBI; TISSUE DISTRIBUTION;

EID: 77955469678     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0203-x     Document Type: Article

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